KEGG   PATHWAY: pkr00260
Entry
pkr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas koreensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pkr00260  Glycine, serine and threonine metabolism
pkr00260

Module
pkr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pkr00260]
pkr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pkr00260]
pkr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pkr00260]
pkr_M00555  Betaine biosynthesis, choline => betaine [PATH:pkr00260]
pkr_M00621  Glycine cleavage system [PATH:pkr00260]
pkr_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pkr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas koreensis [GN:pkr]
Gene
AYO71_23395  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AYO71_12425  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AYO71_07875  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AYO71_03230  homoserine kinase [KO:K02204] [EC:2.7.1.39]
AYO71_11730  thrH; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein [KO:K02203] [EC:3.1.3.3 2.7.1.39]
AYO71_07880  threonine synthase [KO:K01733] [EC:4.2.3.1]
AYO71_23405  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AYO71_27935  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AYO71_27925  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AYO71_26290  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AYO71_25435  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
AYO71_07430  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AYO71_17605  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AYO71_10865  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
AYO71_04450  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AYO71_01590  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AYO71_22395  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
AYO71_05280  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AYO71_02085  amine oxidase [KO:K00274] [EC:1.4.3.4]
AYO71_01420  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
AYO71_23910  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
AYO71_01410  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AYO71_23920  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AYO71_00250  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AYO71_10975  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AYO71_19185  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AYO71_01415  glycine cleavage system protein H [KO:K02437]
AYO71_23905  glycine cleavage system protein H [KO:K02437]
AYO71_16345  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
AYO71_25825  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AYO71_28085  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AYO71_28080  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AYO71_24285  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AYO71_27960  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
AYO71_27955  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
AYO71_27980  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
AYO71_27975  (Fe-S)-binding protein [KO:K21834]
AYO71_27970  electron transfer flavoprotein subunit alpha [KO:K25960]
AYO71_27965  electron transfer flavoprotein subunit beta [KO:K25961]
AYO71_27910  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AYO71_27920  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AYO71_27905  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AYO71_27915  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AYO71_18260  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AYO71_18265  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
AYO71_07355  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AYO71_28050  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AYO71_23915  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AYO71_01620  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AYO71_14990  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
AYO71_15830  racemase [KO:K25316] [EC:5.1.1.10]
AYO71_03450  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AYO71_03445  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AYO71_21470  2,4-diaminobutyrate 4-aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pkr00010  Glycolysis / Gluconeogenesis
pkr00020  Citrate cycle (TCA cycle)
pkr00230  Purine metabolism
pkr00250  Alanine, aspartate and glutamate metabolism
pkr00270  Cysteine and methionine metabolism
pkr00290  Valine, leucine and isoleucine biosynthesis
pkr00300  Lysine biosynthesis
pkr00330  Arginine and proline metabolism
pkr00460  Cyanoamino acid metabolism
pkr00470  D-Amino acid metabolism
pkr00564  Glycerophospholipid metabolism
pkr00620  Pyruvate metabolism
pkr00630  Glyoxylate and dicarboxylate metabolism
pkr00640  Propanoate metabolism
pkr00680  Methane metabolism
pkr00860  Porphyrin metabolism
pkr00920  Sulfur metabolism
KO pathway
ko00260   
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