KEGG   PATHWAY: pleu00564
Entry
pleu00564                   Pathway                                
Name
Glycerophospholipid metabolism - Peromyscus leucopus (white-footed mouse)
Class
Metabolism; Lipid metabolism
Pathway map
pleu00564  Glycerophospholipid metabolism
pleu00564

Module
pleu_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:pleu00564]
pleu_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:pleu00564]
pleu_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:pleu00564]
Other DBs
GO: 0006650
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680609  Pcyt2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
114680680  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
114681054  Lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
114681114  Pla2g4e; LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
114681118  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
114681139  Pla2g4d; cytosolic phospholipase A2 delta isoform X2 [KO:K16342] [EC:3.1.1.4]
114681142  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
114681301  [KO:K01047] [EC:3.1.1.4]
114681304  Pla2g1b; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
114681335  [KO:K01047] [EC:3.1.1.4]
114681350  Plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
114681533  Pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
114681770  Dgka; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
114682568  Pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
114682603  [KO:K01047] [EC:3.1.1.4]
114682727  Pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114682790  Etnppl; LOW QUALITY PROTEIN: ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
114682862  Sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
114683086  [KO:K13512] [EC:2.3.1.23 2.3.1.-]
114683160  Pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
114683432  Pla2g15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
114685393  Pcyt1a; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
114685816  Agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
114687364  [KO:K01047] [EC:3.1.1.4]
114687366  [KO:K01047] [EC:3.1.1.4]
114687369  [KO:K01047] [EC:3.1.1.4]
114687550  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
114688426  Mboat7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
114688924  Ache; acetylcholinesterase isoform X2 [KO:K01049] [EC:3.1.1.7]
114689085  [KO:K01047] [EC:3.1.1.4]
114689172  Plpp2; LOW QUALITY PROTEIN: phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
114689271  [KO:K01047] [EC:3.1.1.4]
114689380  [KO:K01047] [EC:3.1.1.4]
114689418  [KO:K19007] [EC:2.3.1.51]
114691011  Dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
114691363  Agpat4; LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
114691771  Gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
114691772  Cds1; LOW QUALITY PROTEIN: phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
114691817  [KO:K13510] [EC:2.3.1.23 2.3.1.67]
114691842  Dgkq; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
114692366  Plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
114692581  Lpin3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
114692759  Pnpla7; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
114692823  Agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
114692918  Phospho1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
114693033  Chkb; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
114693125  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
114693553  Ptdss2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
114694030  Pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114694040  Pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X4 [KO:K01613] [EC:4.1.1.65]
114694258  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
114694531  Lpcat2; lysophosphatidylcholine acyltransferase 2 isoform X2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
114694639  Chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
114695088  Dgkb; diacylglycerol kinase beta isoform X2 [KO:K00901] [EC:2.7.1.107]
114696106  Lpcat1; LOW QUALITY PROTEIN: lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
114696147  Lclat1; lysocardiolipin acyltransferase 1 isoform X2 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
114696285  Plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
114696298  Gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
114696417  Lpin2; phosphatidate phosphatase LPIN2 isoform X5 [KO:K15728] [EC:3.1.3.4]
114696522  Selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
114696681  Gpd1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
114696773  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
114697054  Gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
114697119  Dgkg; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
114697140  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114697141  Pla2g2d; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114697142  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114697183  Pla2g5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
114697184  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
114697187  Pla2g2c; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114697230  Lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
114697489  [KO:K13512] [EC:2.3.1.23 2.3.1.-]
114697539  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
114697892  Dgkd; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
114698092  Etnk2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
114698468  [KO:K00999] [EC:2.7.8.11]
114698700  Gdpd5; glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1 [KO:K28873]
114698833  Lpin1; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
114699245  Dgke; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
114699355  Chat; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
114699502  Dgkh; LOW QUALITY PROTEIN: diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
114699527  Cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
114699529  Gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
114699536  Crls1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
114699705  Dgkz; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
114700129  [KO:K00006] [EC:1.1.1.8]
114700216  Samd8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
114700281  Etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
114700645  Chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
114701069  Mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
114701486  Pla1a; LOW QUALITY PROTEIN: phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
114701564  Pcyt1b; choline-phosphate cytidylyltransferase B isoform X2 [KO:K00968] [EC:2.7.7.15]
114701874  Agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
114702414  Lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
114703041  Pld4; 5'-3' exonuclease PLD4 isoform X1 [KO:K16860] [EC:3.1.4.4]
114703420  [KO:K01047] [EC:3.1.1.4]
114703628  Plpp1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
114703899  Pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
114704351  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
114705733  Gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
114705796  Agpat1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
114705854  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
114706190  Taz; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
114707134  Gnpat; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
114707269  Cept1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
114707339  [KO:K01047] [EC:3.1.1.4]
114708771  Lpcat3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
114708892  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
114708949  Pgs1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
114709091  Gpat2; LOW QUALITY PROTEIN: glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
114709226  [KO:K00994] [EC:2.7.8.2]
114709248  Gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
114709698  [KO:K06128] [EC:3.1.1.5]
114709773  Mboat2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
114709797  Ptdss1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
114710007  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
119086582  [KO:K01047] [EC:3.1.1.4]
119086583  [KO:K01047] [EC:3.1.1.4]
119087084  [KO:K01047] [EC:3.1.1.4]
119087086  [KO:K01047] [EC:3.1.1.4]
119087201  [KO:K01047] [EC:3.1.1.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
pleu00010  Glycolysis / Gluconeogenesis
pleu00260  Glycine, serine and threonine metabolism
pleu00561  Glycerolipid metabolism
pleu00562  Inositol phosphate metabolism
pleu00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
pleu00565  Ether lipid metabolism
pleu00620  Pyruvate metabolism
KO pathway
ko00564   

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