KEGG   PATHWAY: pmur04530
Entry
pmur04530                   Pathway                                
Name
Tight junction - Protobothrops mucrosquamatus (Taiwan habu)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pmur04530  Tight junction
pmur04530

Other DBs
GO: 0005923
Organism
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
Gene
107282209  RAB8A; ras-related protein Rab-8A [KO:K07901]
107282221  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
107282238  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
107282526  [KO:K06087]
107282566  [KO:K06087]
107282867  TJP3; tight junction protein ZO-3 [KO:K06097]
107282874  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107283087  [KO:K10352]
107283131  CGNL1; cingulin-like protein 1 [KO:K21110]
107283167  RAB8B; ras-related protein Rab-8B [KO:K07902]
107283588  [KO:K21099]
107283633  PCNA; proliferating cell nuclear antigen [KO:K04802]
107284008  MYH11; myosin-11 isoform X1 [KO:K10352]
107284022  PARD3; partitioning defective 3 homolog [KO:K04237]
107284025  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
107284182  BVES; blood vessel epicardial substance [KO:K21108]
107284338  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
107284618  MSN; moesin [KO:K05763]
107284625  AMOT; angiomotin [KO:K16819]
107284705  [KO:K06087]
107284707  CLDN4; claudin-4 [KO:K06087]
107284714  [KO:K06087]
107284757  CLDN25; putative claudin-25 [KO:K06087]
107284983  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
107285213  RAB13; ras-related protein Rab-13 [KO:K06109]
107285298  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
107285369  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
107285466  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107285491  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
107285574  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
107285618  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107285821  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107285832  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
107285846  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
107285899  CLDN18; claudin-18 [KO:K06087]
107285994  [KO:K08020]
107286040  RAPGEF2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
107286384  TUBA1A; tubulin alpha-1A chain [KO:K07374]
107286385  TUBA1C; tubulin alpha-1C chain [KO:K07374]
107286634  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
107286753  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107286834  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
107286837  CLDN12; claudin-12 [KO:K06087]
107286997  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107287052  ACTR2; actin-related protein 2 [KO:K17260]
107287081  PATJ; inaD-like protein [KO:K06092]
107287110  [KO:K07374]
107287134  AMOTL2; angiomotin-like protein 2 [KO:K06104]
107287254  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107287488  CTTN; src substrate cortactin isoform X1 [KO:K06106]
107287678  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
107287741  [KO:K06087]
107287861  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
107288113  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
107288115  [KO:K07374]
107288228  MPDZ; multiple PDZ domain protein [KO:K06095]
107288249  EZR; ezrin [KO:K08007]
107288381  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107288489  SCRIB; protein scribble homolog [KO:K16175]
107288565  [KO:K16684]
107288686  RHOA; transforming protein RhoA [KO:K04513]
107288688  [KO:K04513]
107288785  NF2; merlin [KO:K16684]
107288822  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
107288893  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
107289150  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
107289315  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
107289333  TJAP1; tight junction-associated protein 1 [KO:K06105]
107289380  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
107289557  CLDN23; claudin-23 [KO:K06087]
107289612  AFDN; afadin isoform X2 [KO:K05702]
107289746  OCLN; occludin [KO:K06088]
107289747  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
107289763  ACTR3; actin-related protein 3 [KO:K18584]
107289986  [KO:K07374]
107290017  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107290022  [KO:K06087]
107290030  CLDN19; claudin-19 [KO:K06087]
107290257  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107290261  CLDN11; claudin-11 [KO:K06087]
107290351  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
107290358  CLDN10; claudin-10 isoform X1 [KO:K06087]
107290521  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
107290687  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
107290760  [KO:K06087]
107290769  [KO:K06087]
107291127  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
107291148  [KO:K04345] [EC:2.7.11.11]
107291150  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
107291319  CLDN15; claudin-15 [KO:K06087]
107291465  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
107291521  [KO:K08367]
107291540  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107291638  VASP; LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
107291694  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
107291970  SYMPK; symplekin [KO:K06100]
107291985  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
107292281  JAM2; junctional adhesion molecule B [KO:K06735]
107292307  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
107292363  IGSF5; LOW QUALITY PROTEIN: immunoglobulin superfamily member 5 [KO:K06786]
107292543  RAP1A; ras-related protein Rap-1A [KO:K04353]
107292597  MYH10; myosin-10 isoform X1 [KO:K10352]
107292909  CGN; cingulin [KO:K06102]
107293008  TJP1; tight junction protein ZO-1 [KO:K05701]
107293173  JAM3; junctional adhesion molecule C [KO:K06785]
107293410  CLDN5; claudin-5 [KO:K06087]
107293577  CRB3; protein crumbs homolog 3 [KO:K06090]
107293741  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
107293743  [KO:K12751]
107293744  [KO:K12751]
107293954  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
107293957  CLDN20; claudin-20 [KO:K06087]
107293980  CLDN14; LOW QUALITY PROTEIN: claudin-14 [KO:K06087]
107294002  [KO:K12757]
107294019  [KO:K04345] [EC:2.7.11.11]
107294352  [KO:K07374]
107294355  [KO:K07374]
107294422  TJP2; tight junction protein ZO-2 [KO:K06098]
107294582  AMOTL1; angiomotin-like protein 1 [KO:K06104]
107294632  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
107294640  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
107294933  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107295004  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
107295075  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
107295483  ACTN4; alpha-actinin-4 [KO:K05699]
107295512  F11R; junctional adhesion molecule A [KO:K06089]
107295783  [KO:K10352]
107296007  [KO:K04513]
107296023  [KO:K12791]
107296356  RDX; radixin [KO:K05762]
107296507  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
107296783  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
107296819  [KO:K07374]
107296834  [KO:K17291]
107296976  MPP4; LOW QUALITY PROTEIN: MAGUK p55 subfamily member 4 [KO:K21109]
107297151  [KO:K06106]
107297369  [KO:K17291]
107297372  [KO:K06088]
107297444  SYNPO; synaptopodin [KO:K21112]
107297474  [KO:K06093]
107298009  [KO:K07200]
107298084  MICALL2; MICAL-like protein 2 [KO:K21068]
107298106  [KO:K05692]
107298182  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
107298865  [KO:K06087]
107298894  [KO:K12075]
107299054  [KO:K12791]
107299144  [KO:K06087]
107299154  [KO:K07374]
107299171  [KO:K04354]
107299310  ARHGAP17; rho GTPase-activating protein 17 [KO:K20638]
107299818  [KO:K05757]
107299820  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
107299843  [KO:K06087]
107300207  [KO:K06087]
107300285  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
107300808  [KO:K07200]
107301177  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
107301310  [KO:K06087]
107302456  JUN; transcription factor AP-1 [KO:K04448]
107302506  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
107302683  [KO:K06087]
107302689  MYH9; myosin-9 isoform X1 [KO:K10352]
107303070  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107303183  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107303240  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
107303248  RAP2C; ras-related protein Rap-2c [KO:K07839]
107303268  CLDN2; claudin-2 [KO:K06087]
107303313  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
107303329  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
114922167  [KO:K13365]
114922244  [KO:K06087]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
pmur04520  Adherens junction
pmur04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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