KEGG   PATHWAY: pory00260
Entry
pory00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas oryziphila
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pory00260  Glycine, serine and threonine metabolism
pory00260

Module
pory_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pory00260]
pory_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pory00260]
pory_M00555  Betaine biosynthesis, choline => betaine [PATH:pory00260]
pory_M00621  Glycine cleavage system [PATH:pory00260]
pory_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pory00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas oryziphila [GN:pory]
Gene
EJA05_20325  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EJA05_08325  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EJA05_22225  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EJA05_10860  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EJA05_00395  homoserine kinase [KO:K02204] [EC:2.7.1.39]
EJA05_22220  threonine synthase [KO:K01733] [EC:4.2.3.1]
EJA05_10870  threonine synthase [KO:K01733] [EC:4.2.3.1]
EJA05_01745  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EJA05_24440  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EJA05_01755  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EJA05_23895  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
EJA05_04680  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EJA05_13785  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EJA05_08805  glycerate kinase [KO:K11529] [EC:2.7.1.165]
EJA05_26300  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
EJA05_26945  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EJA05_07450  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
EJA05_25545  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EJA05_25925  NAD(P)/FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
EJA05_22600  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EJA05_01085  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EJA05_22610  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EJA05_01075  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EJA05_19390  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EJA05_20250  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EJA05_27945  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EJA05_22595  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EJA05_01080  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EJA05_04105  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EJA05_26345  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EJA05_24205  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EJA05_26340  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EJA05_01700  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
EJA05_01710  glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
EJA05_01680  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
EJA05_01685  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
EJA05_01690  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
EJA05_01695  electron transfer flavoprotein subunit beta [KO:K25961]
EJA05_01770  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
EJA05_01760  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
EJA05_01775  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
EJA05_01765  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
EJA05_07175  PLP-dependent transferase [KO:K01758] [EC:4.4.1.1]
EJA05_22605  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EJA05_01620  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EJA05_12815  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EJA05_20855  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EJA05_26915  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EJA05_14395  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EJA05_18120  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
EJA05_11195  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
EJA05_15510  alr; alanine racemase [KO:K25317] [EC:5.1.1.10]
EJA05_00195  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EJA05_00200  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EJA05_17655  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
EJA05_19530  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pory00010  Glycolysis / Gluconeogenesis
pory00020  Citrate cycle (TCA cycle)
pory00230  Purine metabolism
pory00250  Alanine, aspartate and glutamate metabolism
pory00270  Cysteine and methionine metabolism
pory00290  Valine, leucine and isoleucine biosynthesis
pory00300  Lysine biosynthesis
pory00330  Arginine and proline metabolism
pory00460  Cyanoamino acid metabolism
pory00470  D-Amino acid metabolism
pory00564  Glycerophospholipid metabolism
pory00620  Pyruvate metabolism
pory00630  Glyoxylate and dicarboxylate metabolism
pory00640  Propanoate metabolism
pory00680  Methane metabolism
pory00860  Porphyrin metabolism
pory00920  Sulfur metabolism
KO pathway
ko00260   
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