KEGG   PATHWAY: rlw00260
Entry
rlw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium laguerreae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rlw00260  Glycine, serine and threonine metabolism
rlw00260

Module
rlw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rlw00260]
rlw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rlw00260]
rlw_M00555  Betaine biosynthesis, choline => betaine [PATH:rlw00260]
rlw_M00621  Glycine cleavage system [PATH:rlw00260]
rlw_M00919  Ectoine degradation, ectoine => aspartate [PATH:rlw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium laguerreae [GN:rlw]
Gene
RlegWSM1455_19280  aspartate kinase [KO:K00928] [EC:2.7.2.4]
RlegWSM1455_21220  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
RlegWSM1455_08655  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
RlegWSM1455_03150  homoserine kinase [KO:K02204] [EC:2.7.1.39]
RlegWSM1455_03275  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
RlegWSM1455_18290  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
RlegWSM1455_06385  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
RlegWSM1455_22595  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RlegWSM1455_28445  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RlegWSM1455_31625  glycerate kinase [KO:K00865] [EC:2.7.1.165]
RlegWSM1455_08175  glycerate kinase [KO:K11529] [EC:2.7.1.165]
RlegWSM1455_22545  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
RlegWSM1455_11100  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
RlegWSM1455_17645  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
RlegWSM1455_28215  dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
RlegWSM1455_17650  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
RlegWSM1455_14075  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
RlegWSM1455_14890  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
RlegWSM1455_14885  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
RlegWSM1455_19765  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
RlegWSM1455_31200  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
RlegWSM1455_12970  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
RlegWSM1455_10600  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
RlegWSM1455_31215  DUF1989 domain-containing protein [KO:K00605] [EC:2.1.2.10]
RlegWSM1455_31280  aminomethyltransferase family protein [KO:K00605] [EC:2.1.2.10]
RlegWSM1455_10590  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
RlegWSM1455_20005  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
RlegWSM1455_33320  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
RlegWSM1455_09005  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
RlegWSM1455_10595  gcvH; glycine cleavage system protein GcvH [KO:K02437]
RlegWSM1455_05915  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
RlegWSM1455_04540  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
RlegWSM1455_04545  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
RlegWSM1455_07645  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
RlegWSM1455_26530  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
RlegWSM1455_28080  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
RlegWSM1455_02825  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
RlegWSM1455_28075  FAD-binding oxidoreductase [KO:K21832] [EC:1.14.13.251]
RlegWSM1455_18480  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
RlegWSM1455_18495  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
RlegWSM1455_18475  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
RlegWSM1455_18485  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
RlegWSM1455_10445  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
RlegWSM1455_18120  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
RlegWSM1455_24185  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
RlegWSM1455_07950  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
RlegWSM1455_21195  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
RlegWSM1455_34000  alanine racemase [KO:K01753] [EC:4.3.1.18]
RlegWSM1455_21475  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
RlegWSM1455_21470  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
RlegWSM1455_13220  ectoine synthase [KO:K06720] [EC:4.2.1.108]
RlegWSM1455_24195  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
RlegWSM1455_24200  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
RlegWSM1455_24140  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
RlegWSM1455_24145  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rlw00010  Glycolysis / Gluconeogenesis
rlw00020  Citrate cycle (TCA cycle)
rlw00230  Purine metabolism
rlw00250  Alanine, aspartate and glutamate metabolism
rlw00270  Cysteine and methionine metabolism
rlw00290  Valine, leucine and isoleucine biosynthesis
rlw00300  Lysine biosynthesis
rlw00330  Arginine and proline metabolism
rlw00460  Cyanoamino acid metabolism
rlw00470  D-Amino acid metabolism
rlw00564  Glycerophospholipid metabolism
rlw00600  Sphingolipid metabolism
rlw00620  Pyruvate metabolism
rlw00630  Glyoxylate and dicarboxylate metabolism
rlw00640  Propanoate metabolism
rlw00680  Methane metabolism
rlw00860  Porphyrin metabolism
rlw00920  Sulfur metabolism
KO pathway
ko00260   
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