PATHWAY: rn00541 Help
Entry
Name
Biosynthesis of various nucleotide sugars
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
rn00541 Biosynthesis of various nucleotide sugars
Module
M00063 CMP-3-deoxy-D-manno-octulosonate biosynthesis, ribulose-5P => CMP-KDO [PATH:rn00541 ]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis, sedoheptulose-7P => ADP-LDmanHep [PATH:rn00541 ]
M00761 Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:rn00541 ]
M00793 dTDP-L-rhamnose biosynthesis, glucose-1P => dTDP-L-Rha [PATH:rn00541 ]
M00922 CMP-Neu5Ac biosynthesis, bacteria, UDP-GlcNAc => CMP-Neu5Ac [PATH:rn00541 ]
M00923 UDP-L-FucNAm biosynthesis, UDP-GlcNAc => UDP-L-FucNAm [PATH:rn00541 ]
M00955 CMP-Neu5Ac/Neu5Gc biosynthesis, animals, UDP-GlcNAc => CMP-Neu5Ac => CMP-Neu5Gc [PATH:rn00541 ]
Reaction
R00100 NADH:ferricytochrome-b5 oxidoreductase
R00286 UDP-glucose:NAD+ 6-oxidoreductase
R00289 UTP:alpha-D-glucose-1-phosphate uridylyltransferase
R00293 UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)
R00414 UDP-N-acetyl-D-glucosamine 2-epimerase
R00416 UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
R00418 UDP-N-acetyl-D-glucosamine 4-epimerase
R00420 UDP-N-acetyl-D-glucosamine 2-epimerase
R00421 UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase
R00885 GTP:alpha-D-mannose-1-phosphate guanylyltransferase
R00888 GDP-alpha-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-alpha-D-rhamnose-forming); GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)
R00956 CTP:alpha-D-glucose-1-phosphate cytidylyltransferase
R01115 CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)
R01117 CTP:N-acetylneuraminate cytidylyltransferase
R01387 UDP-glucuronate 5'-epimerase
R01530 D-arabinose-5-phosphate aldose-ketose-isomerase
R01803 N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)
R01804 phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
R01805 N-acetylneuraminate 9-phosphate phosphohydrolase
R01811 N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
R02328 dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase
R02426 CDPglucose 4,6-hydro-lyase
R02705 ATP:N-acyl-D-mannosamine 6-phosphotransferase
R02773 dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
R02776 dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase
R02777 dTDP-beta-L-rhamnose:NADP+ 4-oxidoreductase; dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase
R03254 phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming); 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating)
R03317 UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
R03350 3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase
R03351 CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase
R03391 CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD+ 3-oxydoreductase
R03392 CDP-4-dehydro-3,6-dideoxy-D-glucose:NADP+ 3-oxydoreductase
R03396 GDP-6-deoxy-D-talose:NAD+ 4-oxidoreductase
R03397 GDP-6-deoxy-D-mannose:NAD+ 4-oxidoreductase
R03398 GDP-6-deoxy-D-talose:NADP+ 4-oxidoreductase
R03399 GDP-6-deoxy-D-mannose:NADP+ 4-oxidoreductase
R04215 CTP:N-glycoloylneuraminate cytidylyltransferase
R04265 CDP-alpha-D-paratose:NADP+ 4-oxidoreductase
R04266 CDP-3,6-dideoxy-D-glucose 2-epimerase
R04435 phosphoenolpyruvate:N-acetyl-D-mannosamine-6-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming); N-acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
R04438 dTDP-4-amino-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase
R04529 UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase
R05176 ADP-D-glycero-D-manno-heptose 6-epimerase
R05644 ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
R05645 D-glycero-beta-D-manno-heptose-7-phosphate aldose-ketose-isomerase
R05646 ATP:D-glycero-beta-D-manno-heptose 7-phosphate 1-phosphotransferase
R05647 D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase
R05687 dTDP-4-keto-6-deoxyglucose reductase
R05692 GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
R06423 dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase
R06424 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase
R06513 dTDPglucose 4,6-hydro-lyase
R06514 dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3,5-epimerase; dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase
R07661 UDP-4-deoxy-4-formamido-L-arabinose:undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinosyltransferase
R07662 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol amidohydrolase
R08704 UDP-4-dehydro-6-deoxy-glucose 3,5-epimerase
R08705 UDP-L-rhamnose:NADP+ 4-oxidoreductase
R08706 UDP-N-acetyl-D-glucosaminuronate 4-epimerase
R08708 CDP-4-dehydro-3,6-dideoxy-D-glucose 5-epimerase; CDP-3,6-dideoxy-D-erythro-hexos-4-ulose 5-epimerase
R08709 CDP-ascarylose:NAD+ 4-oxidoreductase
R08710 CDP-ascarylose:NADP+ 4-oxidoreductase
R08711 CDP-abequose:NADP+ 4-oxidoreductase
R09600 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase
R09697 UDP-N-acetylglucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose-forming)
R09769 D-glycero-alpha-D-manno-heptose 7-phosphate aldose-ketose-isomerase
R09770 ATP:D-glycero-alpha-D-manno-heptose 7-phosphate 1-phosphotransferase
R09771 D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase
R09772 GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
R09824 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase
R09825 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine:2-oxoglutarate aminotransferase
R09834 UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose hydrolase
R09841 phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transfering, 2-carboxy-2-oxoethyl-forming)
R09842 acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine 4-N-acetyltransferase
R09843 CTP:pseudaminate cytidylyltransferase
R09873 acetyl-CoA:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase
R09904 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase
R10099 acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase; acetyl-CoA:UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose 4-N-acetyltransferase
R10100 acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate 3-N-acetyltransferase
R10140 UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD+ 3-oxidoreductase
R10141 UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase
R10142 acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-galactose N-acetyltransferase
R10174 acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-glucose N-acetyltransferase
R10182 CTP:N,N'-diacetyllegionaminate cytidylyltransferase
R10187 UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising)
R10190 dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
R10266 UDP-N-acetyl-alpha-D-glucosamine hydro-lyase
R10304 phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase
R10420 GDP-beta-L-colitose:NAD+ 4-oxidoreductase (5-epimerizing)
R10421 GDP-beta-L-colitose:NADP+ 4-oxidoreductase (5-epimerizing)
R10460 GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase
R10514 acetyl-CoA:GDP-4-amino-4,6-dideoxy-alpha-D-mannose N-acetyltransferase
R10536 dTDP-alpha-D-fucopyranose furanomutase
R10676 UDP-2-acetamido-2,6-dideoxy-beta-L-talose 2-epimerase
R11409 GDP-4-dehydro-alpha-D-rhamnose 3-hydro-lyase
R11439 phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
R11440 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate 9-phosphohydrolase
R11441 CTP:3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate cytidylyltransferase
R12556 UDP-N-acetyl-alpha-D-quinovosamine:NADP+ 4-dehydrogenase
R12760 UDP-N-acetyl-alpha-D-quinovosamine:NAD+ 4-dehydrogenase
R12790 10-formyltetrahydrofolate:GDP-alpha-D-perosamine N-formyltransferase
R13350 UDP-N-acetyl-alpha-D-glucosaminuronate carboxy-lyase
R13401 UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactose:2-oxoglutarate ligase (ADP-forming)
Compound
C00043 UDP-N-acetyl-alpha-D-glucosamine
C00128 CMP-N-acetylneuraminate
C00203 UDP-N-acetyl-D-galactosamine
C00688 dTDP-4-dehydro-beta-L-rhamnose
C01112 D-Arabinose 5-phosphate
C01170 UDP-N-acetyl-D-mannosamine
C01187 3-Deoxy-D-manno-octulosonate
C01219 CDP-4-dehydro-6-deoxy-D-glucose
C01222 GDP-4-dehydro-6-deoxy-D-mannose
C03187 dTDP-6-deoxy-beta-L-talose
C03410 N-Glycoloyl-neuraminate
C03598 CDP-3,6-dideoxy-D-glucose
C03599 CDP-3,6-dideoxy-D-mannose
C03691 CMP-N-glycoloylneuraminate
C04089 UDP-4-dehydro-6-deoxy-D-glucose
C04121 CMP-3-deoxy-D-manno-octulosonate
C04257 N-Acetyl-D-mannosamine 6-phosphate
C04268 dTDP-4-amino-4,6-dideoxy-D-glucose
C04297 CDP-4-dehydro-3,6-dideoxy-D-glucose
C04346 dTDP-4-amino-4,6-dideoxy-D-galactose
C04478 3-Deoxy-D-manno-octulosonate 8-phosphate
C04501 N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04613 UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
C04630 UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
C05382 Sedoheptulose 7-phosphate
C06018 dTDP-4-acetamido-4,6-dideoxy-D-glucose
C06240 UDP-N-acetyl-D-mannosaminouronate
C06241 N-Acetylneuraminate 9-phosphate
C06397 ADP-D-glycero-beta-D-manno-heptose
C06398 ADP-L-glycero-beta-D-manno-heptose
C07836 D-glycero-beta-D-manno-Heptose 7-phosphate
C07838 D-glycero-beta-D-manno-Heptose 1-phosphate
C11472 D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C11907 dTDP-4-oxo-6-deoxy-D-glucose
C11908 3,6-Dideoxy-3-oxo-dTDP-D-glucose
C11925 dTDP-3-amino-3,6-dideoxy-D-glucose
C13952 UDP-N-acetyl-D-galactosaminuronic acid
C16156 Undecaprenyl phosphate alpha-L-Ara4FN
C16157 Undecaprenyl phosphate alpha-L-Ara4N
C17326 CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C19725 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19823 UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19878 D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879 D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880 D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881 GDP-D-glycero-alpha-D-manno-heptose
C19947 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose
C19960 dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose
C19961 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971 UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972 2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20156 dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose
C20357 UDP-N,N'-diacetylbacillosamine
C20359 UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395 UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
C20415 dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
C20418 N,N'-Diacetyllegionaminate
C20419 CMP-N,N'-diacetyllegionaminate
C20424 2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose
C20612 GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose
C20638 GDP-4-amino-4,6-dideoxy-alpha-D-mannose
C20672 GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
C20682 dTDP-alpha-D-fucofuranose
C20768 UDP-2-acetamido-2,6-dideoxy-beta-L-talose
C20769 UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-4-hexulose
C20774 UDP-N-acetyl-beta-L-fucosamine
C20934 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C21383 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate
C21384 CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C22245 UDP-2-acetamido-2-deoxy-alpha-D-galacturonamide
C22246 UDP-2,3-dideoxy-2-acetamido-3-acetamidino-alpha-D-mannuronic acid
C22247 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucopyranose
C22248 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose
C22249 2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose
C22250 5-N-Acetyl-7-N-(D-alanyl)-legionaminic acid
C22251 CMP-5-N-acetyl-7-N-(D-alanyl)-legionaminic acid
C22252 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose
C22253 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose
C22254 2,4-Diacetamido-2,4,6-trideoxy-beta-L-gulose
C22255 5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid
C22256 CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid
C22257 dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose
C22259 UDP-2-acetamido-2,6-dideoxy-beta-L-mannose
C22260 UDP-2-acetamido-2,6-dideoxy-beta-L-glucose
C22261 UDP-2-acetamido-2,6-dideoxy-alpha-D-galactose
C22262 UDP-2-acetamido-2,6-dideoxy-alpha-D-glucose
C22270 UDP-2,6-dideoxy-2-acetamidino-beta-L-galactose
C22276 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine
C22397 GDP-N-formyl-alpha-D-perosamine
C22575 UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-galactose
C22576 UDP-2-acetamido-2-deoxy-L-altruronic acid
C22938 UDP-N-acetyl-alpha-D-xylosamine
Reference
Authors
Samuel G, Reeves P
Title
Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly.
Journal
Reference
Authors
Burrows LL, Charter DF, Lam JS
Title
Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B-band lipopolysaccharide gene cluster.
Journal
Reference
Authors
Belanger M, Burrows LL, Lam JS
Title
Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide.
Journal
Reference
Authors
Dean CR, Goldberg JB
Title
The wbpM gene in Pseudomonas aeruginosa serogroup O17 resides on a cryptic copy of the serogroup O11 O antigen gene locus.
Journal
Reference
Authors
Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L
Title
Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.
Journal
Reference
Authors
Westman EL, Preston A, Field RA, Lam JS
Title
Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters.
Journal
Reference
Authors
King JD, Kocincova D, Westman EL, Lam JS
Title
Review: Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa.
Journal
Reference
Authors
Perepelov AV, Liu B, Senchenkova SN, Shashkov AS, Shevelev SD, Feng L, Wang L, Knirel YA
Title
Structure of the O-antigen and characterization of the O-antigen gene cluster of Escherichia coli O108 containing 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic (8-epilegionaminic) acid.
Journal
Reference
Authors
Hwang S, Aronov A, Bar-Peled M
Title
The Biosynthesis of UDP-D-QuiNAc in Bacillus cereus ATCC 14579.
Journal
Reference
Authors
McDonald ND, DeMeester KE, Lewis AL, Grimes CL, Boyd EF
Title
Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide.
Journal
Related pathway
rn00051 Fructose and mannose metabolism
rn00520 Amino sugar and nucleotide sugar metabolism
rn00540 Lipopolysaccharide biosynthesis
KO pathway