KEGG PATHWAY: rze00600

KEGG

PATHWAY: rze00600

Entry

rze00600                    Pathway

Name

Sphingolipid metabolism - Rhagoletis zephyria (snowberry fruit fly)

Class

Metabolism; Lipid metabolism

Pathway map

Sphingolipid metabolism

Module

Sphingosine degradation [PATH:rze00600]

Other DBs

GO:

Organism

Rhagoletis zephyria (snowberry fruit fly) [GN:rze]

Gene

serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]

serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]

serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]

serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]

ceramide synthase 5 isoform X1 [KO:K23727] [EC:2.3.1.291]

neutral ceramidase isoform X1 [KO:K12349] [EC:3.5.1.23]

neutral ceramidase-like [KO:K12349] [EC:3.5.1.23]

alkaline ceramidase [KO:K01441] [EC:3.5.1.23]

sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]

sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]

sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]

putative neutral sphingomyelinase isoform X1 [KO:K12351] [EC:3.1.4.12]

sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]

ceramide kinase [KO:K04715] [EC:2.7.1.138]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]

ceramide phosphoethanolamine synthase [KO:K26283] [EC:2.7.8.48]

sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]

sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]

sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]

sphingosine-1-phosphate lyase [KO:K01634] [EC:4.1.2.27]

sphingosine-1-phosphate lyase-like [KO:K01634] [EC:4.1.2.27]

ceramide glucosyltransferase-B-like [KO:K00720] [EC:2.4.1.80]

ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]

glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]

glucosylceramidase [KO:K01201] [EC:3.2.1.45]

LOW QUALITY PROTEIN: non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]

beta-galactosidase [KO:K12309] [EC:3.2.1.23]

beta-galactosidase [KO:K12309] [EC:3.2.1.23]

beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]

beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]

LOW QUALITY PROTEIN: chitooligosaccharidolytic beta-N-acetylglucosaminidase-like [KO:K12373] [EC:3.2.1.52]

beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]

chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]

chitooligosaccharidolytic beta-N-acetylglucosaminidase-like [KO:K12373] [EC:3.2.1.52]

beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]

prosaposin [KO:K12382]

Compound

L-Serine

Palmitoyl-CoA

N-Acylsphingosine

Sphingosine

Ethanolamine phosphate

Sphingomyelin

Sphinganine

Sphinganine 1-phosphate

Glucosylceramide

Lactosylceramide

Psychosine

Galactosylceramide

3-Dehydrosphinganine

Ceramide 1-phosphate

D-Glucosylsphingosine

Globoside

Lactosylceramide sulfate

Sphingosyl-phosphocholine

GM3

alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Ceramide 2-aminoethylphosphonate

Ceramide phosphoethanolamine

Sphingosine 1-phosphate

Sulfatide

Digalactosylceramide

Digalactosylceramide sulfate

GM4

GA2

GA1

Dihydroceramide

Phytosphingosine

Phytoceramide

Gangliotriaosylceramide-II3 sulfate

Reference

Authors

Merrill AH Jr.

Title

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.

Journal

J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200

Reference

Authors

Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.

Title

Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.

Journal

J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462

Reference

Authors

Hannun YA, Luberto C, Argraves KM.

Title

Enzymes of sphingolipid metabolism: from modular to integrative signaling.

Journal

Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k

Reference

Authors

Merrill AH Jr, Wang E.

Title

Enzymes of ceramide biosynthesis.

Journal

Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6

Reference

Authors

Hirschberg K, Rodger J, Futerman AH.

Title

The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.

Journal

Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751

Reference

Authors

Dickson RC, Lester RL.

Title

Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.

Journal

Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2

Related
pathway

Glycine, serine and threonine metabolism

Glycosphingolipid biosynthesis - lacto and neolacto series

Glycosphingolipid biosynthesis - globo and isoglobo series

Glycosphingolipid biosynthesis - ganglio series

KO pathway

LinkDB

DBGET integrated database retrieval system