KEGG   PATHWAY: sce03410
Entry
sce03410                    Pathway                                
Name
Base excision repair - Saccharomyces cerevisiae (budding yeast)
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
sce03410  Base excision repair
sce03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YAL015C  NTG1; bifunctional N-glycosylase/AP lyase NTG1 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
YBR087W  RFC5; replication factor C subunit 5 [KO:K10756]
YBR088C  POL30; proliferating cell nuclear antigen [KO:K04802]
YBR223C  TDP1; tyrosyl-DNA phosphodiesterase 1 [KO:K10862] [EC:3.1.4.-]
YBR278W  DPB3; DNA polymerase epsilon noncatalytic subunit [KO:K03506] [EC:2.7.7.7]
YDL102W  POL3; DNA-directed DNA polymerase delta POL3 [KO:K02327] [EC:2.7.7.7]
YDL164C  CDC9; DNA ligase (ATP) CDC9 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
YDR121W  DPB4; DNA polymerase epsilon noncatalytic subunit [KO:K02326] [EC:2.7.7.7]
YER142C  MAG1; DNA-3-methyladenine glycosylase II [KO:K01247] [EC:3.2.2.21]
YJL065C  DLS1; Dls1p [KO:K03506] [EC:2.7.7.7]
YJR006W  POL31; DNA-directed DNA polymerase delta subunit POL31 [KO:K02328]
YJR043C  POL32; DNA polymerase delta subunit POL32 [KO:K03504]
YJR068W  RFC2; replication factor C subunit 2 [KO:K10755]
YKL113C  RAD27; multifunctional nuclease RAD27 [KO:K04799] [EC:3.1.-.-]
YKL114C  APN1; DNA-(apurinic or apyrimidinic site) lyase APN1 [KO:K10771] [EC:3.1.11.2]
YML021C  UNG1; uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
YML060W  OGG1; 8-oxoguanine glycosylase OGG1 [KO:K03660] [EC:3.2.2.- 4.2.99.18]
YNL262W  POL2; DNA polymerase epsilon catalytic subunit [KO:K02324] [EC:2.7.7.7]
YNL290W  RFC3; replication factor C subunit 3 [KO:K10756]
YOL043C  NTG2; bifunctional N-glycosylase/AP lyase NTG2 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
YOL094C  RFC4; replication factor C subunit 4 [KO:K10755]
YOR217W  RFC1; replication factor C subunit 1 [KO:K10754]
YOR258W  HNT3; DNA 5'-adenosine monophosphate hydrolase [KO:K10863] [EC:3.6.1.70 3.6.1.71 3.6.1.72]
YOR330C  MIP1; DNA-directed DNA polymerase gamma MIP1 [KO:K02332] [EC:2.7.7.7]
YPR175W  DPB2; DNA polymerase epsilon noncatalytic subunit [KO:K02325] [EC:2.7.7.7]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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