KEGG   PATHWAY: setr00330
Entry
setr00330                   Pathway                                
Name
Arginine and proline metabolism - Suncus etruscus (white-toothed pygmy shrew)
Class
Metabolism; Amino acid metabolism
Pathway map
setr00330  Arginine and proline metabolism
setr00330

Module
setr_M00015  Proline biosynthesis, glutamate => proline [PATH:setr00330]
setr_M00047  Creatine pathway [PATH:setr00330]
setr_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:setr00330]
setr_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:setr00330]
setr_M00970  Proline degradation, proline => glutamate [PATH:setr00330]
setr_M00972  Proline metabolism [PATH:setr00330]
Other DBs
GO: 0006525 0006560
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125994772  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
125994794  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial [KO:K18123] [EC:4.1.3.16]
125994922  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
125995069  PRODH; proline dehydrogenase 1, mitochondrial [KO:K00318] [EC:1.5.5.2]
125997128  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
125998020  SAT2; thialysine N-epsilon-acetyltransferase isoform X1 [KO:K00657] [EC:2.3.1.57]
125998254  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
125998703  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
125999202  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125999206  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
125999387  SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
126001485  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial [KO:K00286] [EC:1.5.1.2]
126002942  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
126003918  L3HYPDH; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
126004049  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
126005893  AMD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
126006426  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
126006592  AGMAT; agmatinase, mitochondrial [KO:K27001]
126006669  ALDH4A1; LOW QUALITY PROTEIN: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
126007251  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
126011126  AZIN2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
126011201  [KO:K01611] [EC:4.1.1.50]
126011563  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
126013406  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
126013458  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
126013692  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
126017510  SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
126018152  P4HA3; prolyl 4-hydroxylase subunit alpha-3 [KO:K00472] [EC:1.14.11.2]
126018368  CARNS1; carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
126020319  CNDP1; beta-Ala-His dipeptidase [KO:K05604] [EC:3.4.13.20]
126020324  CNDP2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
126020898  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
126020900  CKMT1A; creatine kinase U-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
126021768  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
126022095  [KO:K14455] [EC:2.6.1.1]
126023505  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
126024073  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
126024751  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
126025522  [KO:K01611] [EC:4.1.1.50]
126027151  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
126027186  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
126027622  PRODH2; hydroxyproline dehydrogenase [KO:K11394] [EC:1.5.5.3]
126027733  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
126028248  CKM; creatine kinase M-type [KO:K27382]
126029636  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
126030681  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
126030732  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
126030884  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
126031066  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
126031117  DAO; LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
126031122  [KO:K01611] [EC:4.1.1.50]
126032308  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
126033351  CKB; LOW QUALITY PROTEIN: creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
126033815  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
setr00020  Citrate cycle (TCA cycle)
setr00220  Arginine biosynthesis
setr00250  Alanine, aspartate and glutamate metabolism
setr00260  Glycine, serine and threonine metabolism
setr00270  Cysteine and methionine metabolism
setr00310  Lysine degradation
setr00410  beta-Alanine metabolism
setr00470  D-Amino acid metabolism
setr00480  Glutathione metabolism
setr00630  Glyoxylate and dicarboxylate metabolism
setr00650  Butanoate metabolism
setr00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

DBGET integrated database retrieval system