KEGG   PATHWAY: setr00260
Entry
setr00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Suncus etruscus (white-toothed pygmy shrew)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
setr00260  Glycine, serine and threonine metabolism
setr00260

Module
setr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:setr00260]
setr_M00047  Creatine pathway [PATH:setr00260]
setr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:setr00260]
setr_M00555  Betaine biosynthesis, choline => betaine [PATH:setr00260]
setr_M00621  Glycine cleavage system [PATH:setr00260]
setr_M00974  Betaine metabolism, animals, betaine => glycine [PATH:setr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125994814  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
125995981  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
125997481  PHGDH; LOW QUALITY PROTEIN: D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125997812  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
125999200  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
125999202  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125999206  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
126000012  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
126001877  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
126003510  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
126006258  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
126006426  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
126007148  [KO:K15789] [EC:1.1.1.103]
126008043  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
126008947  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
126009328  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
126009377  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
126011544  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
126011675  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
126012577  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
126013209  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
126013570  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
126013693  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
126014072  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
126014425  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
126017145  [KO:K00276] [EC:1.4.3.21]
126020421  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
126020534  [KO:K02437]
126020898  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
126020977  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
126022226  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
126022408  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
126025636  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
126027285  GCSH; glycine cleavage system H protein, mitochondrial isoform X1 [KO:K02437]
126029636  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
126030691  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
126031117  DAO; LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
126031268  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
setr00010  Glycolysis / Gluconeogenesis
setr00020  Citrate cycle (TCA cycle)
setr00230  Purine metabolism
setr00250  Alanine, aspartate and glutamate metabolism
setr00270  Cysteine and methionine metabolism
setr00290  Valine, leucine and isoleucine biosynthesis
setr00330  Arginine and proline metabolism
setr00470  D-Amino acid metabolism
setr00564  Glycerophospholipid metabolism
setr00600  Sphingolipid metabolism
setr00620  Pyruvate metabolism
setr00630  Glyoxylate and dicarboxylate metabolism
setr00640  Propanoate metabolism
setr00860  Porphyrin metabolism
setr00920  Sulfur metabolism
KO pathway
ko00260   

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