KEGG   PATHWAY: sfiy00260
Entry
sfiy00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces finlayi
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sfiy00260  Glycine, serine and threonine metabolism
sfiy00260

Module
sfiy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sfiy00260]
sfiy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sfiy00260]
sfiy_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sfiy00260]
sfiy_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sfiy00260]
sfiy_M00621  Glycine cleavage system [PATH:sfiy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces finlayi [GN:sfiy]
Gene
F0344_19105  aspartate kinase [KO:K00928] [EC:2.7.2.4]
F0344_19110  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
F0344_24755  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
F0344_10020  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
F0344_10010  homoserine kinase [KO:K00872] [EC:2.7.1.39]
F0344_10015  threonine synthase [KO:K01733] [EC:4.2.3.1]
F0344_11615  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
F0344_15325  threonine synthase [KO:K01733] [EC:4.2.3.1]
F0344_32620  aminotransferase class V-fold PLP-dependent enzyme [KO:K01620] [EC:4.1.2.48]
F0344_09455  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00600] [EC:2.1.2.1]
F0344_09970  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00600] [EC:2.1.2.1]
F0344_03925  glycerate kinase [KO:K00865] [EC:2.7.1.165]
F0344_15685  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
F0344_16515  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
F0344_09245  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
F0344_14930  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
F0344_29340  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
F0344_05200  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
F0344_05205  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
F0344_31590  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
F0344_09445  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
F0344_27510  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
F0344_33110  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
F0344_09450  gcvH; glycine cleavage system protein GcvH [KO:K02437]
F0344_02810  FAD-dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
F0344_25945  glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
F0344_03890  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
F0344_03225  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
F0344_08580  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
F0344_08615  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
F0344_21965  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
F0344_17600  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
F0344_09460  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
F0344_12670  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
F0344_08015  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
F0344_23895  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
F0344_28215  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
F0344_28210  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
F0344_07155  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
F0344_29045  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
F0344_29050  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
F0344_29040  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
F0344_29035  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
F0344_23440  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
F0344_28390  aminotransferase class V-fold PLP-dependent enzyme [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sfiy00010  Glycolysis / Gluconeogenesis
sfiy00020  Citrate cycle (TCA cycle)
sfiy00230  Purine metabolism
sfiy00250  Alanine, aspartate and glutamate metabolism
sfiy00270  Cysteine and methionine metabolism
sfiy00290  Valine, leucine and isoleucine biosynthesis
sfiy00300  Lysine biosynthesis
sfiy00330  Arginine and proline metabolism
sfiy00460  Cyanoamino acid metabolism
sfiy00470  D-Amino acid metabolism
sfiy00564  Glycerophospholipid metabolism
sfiy00600  Sphingolipid metabolism
sfiy00620  Pyruvate metabolism
sfiy00630  Glyoxylate and dicarboxylate metabolism
sfiy00640  Propanoate metabolism
sfiy00680  Methane metabolism
sfiy00860  Porphyrin metabolism
sfiy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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