KEGG   PATHWAY: sfj00260
Entry
sfj00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Serratia ficaria
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sfj00260  Glycine, serine and threonine metabolism
sfj00260

Module
sfj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sfj00260]
sfj_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sfj00260]
sfj_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sfj00260]
sfj_M00555  Betaine biosynthesis, choline => betaine [PATH:sfj00260]
sfj_M00621  Glycine cleavage system [PATH:sfj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Serratia ficaria [GN:sfj]
Gene
SAMEA4384070_4446  lysC; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
SAMEA4384070_0712  thrA; Aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
SAMEA4384070_4719  metL; Aspartokinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
SAMEA4384070_4605  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SAMEA4384070_0713  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
SAMEA4384070_0714  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
SAMEA4384070_1717  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SAMEA4384070_3748  glyA; Pyridoxal-phosphate-dependent serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAMEA4384070_0390  ghrA_1; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SAMEA4384070_1971  ghrA_2; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SAMEA4384070_0023  ghrB_1; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SAMEA4384070_0821  glxK_1; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
SAMEA4384070_1169  glxK_2; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
SAMEA4384070_1346  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SAMEA4384070_0706  cobC; Alpha-ribazole phosphatase [KO:K15634] [EC:5.4.2.11]
SAMEA4384070_4753  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SAMEA4384070_4051  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SAMEA4384070_1745  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SAMEA4384070_0694  serB_1; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SAMEA4384070_2359  ydfG_2; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SAMEA4384070_4757  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SAMEA4384070_4756  tdh_2; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SAMEA4384070_4041  gcvP; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
SAMEA4384070_4043  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SAMEA4384070_4711  lpd; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAMEA4384070_4125  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAMEA4384070_4042  gcvH; Glycine cleavage system H protein [KO:K02437]
SAMEA4384070_3865  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
SAMEA4384070_1557  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SAMEA4384070_1555  betB_2; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAMEA4384070_1671  cbs; Putative cystathionine beta-synthase Rv1077 [KO:K01697] [EC:4.2.1.22]
SAMEA4384070_1670  metC_1; Cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
SAMEA4384070_1673  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
SAMEA4384070_2855  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
SAMEA4384070_4681  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
SAMEA4384070_0007  tdcB_1; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
SAMEA4384070_2560  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
SAMEA4384070_3541  ygeA; putative racemase [KO:K25316] [EC:5.1.1.10]
SAMEA4384070_2718  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
SAMEA4384070_2717  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
SAMEA4384070_2486  dat; Diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
SAMEA4384070_2485  ddc_1; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sfj00010  Glycolysis / Gluconeogenesis
sfj00020  Citrate cycle (TCA cycle)
sfj00230  Purine metabolism
sfj00250  Alanine, aspartate and glutamate metabolism
sfj00270  Cysteine and methionine metabolism
sfj00290  Valine, leucine and isoleucine biosynthesis
sfj00300  Lysine biosynthesis
sfj00330  Arginine and proline metabolism
sfj00460  Cyanoamino acid metabolism
sfj00470  D-Amino acid metabolism
sfj00564  Glycerophospholipid metabolism
sfj00600  Sphingolipid metabolism
sfj00620  Pyruvate metabolism
sfj00630  Glyoxylate and dicarboxylate metabolism
sfj00640  Propanoate metabolism
sfj00680  Methane metabolism
sfj00860  Porphyrin metabolism
sfj00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system