KEGG   PATHWAY: sgm00260
Entry
sgm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces aurantiacus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sgm00260  Glycine, serine and threonine metabolism
sgm00260

Module
sgm_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sgm00260]
sgm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sgm00260]
sgm_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sgm00260]
sgm_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sgm00260]
sgm_M00555  Betaine biosynthesis, choline => betaine [PATH:sgm00260]
sgm_M00621  Glycine cleavage system [PATH:sgm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces aurantiacus [GN:sgm]
Gene
GCM10017557_45140  aspartokinase [KO:K00928] [EC:2.7.2.4]
GCM10017557_45150  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
GCM10017557_54900  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
GCM10017557_25650  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
GCM10017557_04790  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
GCM10017557_25630  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
GCM10017557_25640  threonine synthase [KO:K01733] [EC:4.2.3.1]
GCM10017557_28120  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
GCM10017557_37700  threonine synthase [KO:K01733] [EC:4.2.3.1]
GCM10017557_74790  threonine aldolase [KO:K01620] [EC:4.1.2.48]
GCM10017557_06360  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
GCM10017557_24140  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GCM10017557_25540  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GCM10017557_30760  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GCM10017557_20530  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GCM10017557_14410  glycerate kinase [KO:K00865] [EC:2.7.1.165]
GCM10017557_38410  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
GCM10017557_23630  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
GCM10017557_71630  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
GCM10017557_36890  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
GCM10017557_41510  hypothetical protein [KO:K01079] [EC:3.1.3.3]
GCM10017557_64550  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
GCM10017557_11190  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
GCM10017557_11200  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
GCM10017557_05330  hypothetical protein [KO:K00274] [EC:1.4.3.4]
GCM10017557_02420  amine oxidase [KO:K00276] [EC:1.4.3.21]
GCM10017557_17450  hypothetical protein [KO:K00276] [EC:1.4.3.21]
GCM10017557_69540  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
GCM10017557_24120  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
GCM10017557_60220  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
GCM10017557_24130  gcvH; glycine cleavage system H protein [KO:K02437]
GCM10017557_14340  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
GCM10017557_69170  choline oxidase [KO:K17755] [EC:1.1.3.17]
GCM10017557_22150  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
GCM10017557_22220  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
GCM10017557_30790  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
GCM10017557_69210  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
GCM10017557_69200  solA; N-methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
GCM10017557_31990  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
GCM10017557_41470  cysA; putative cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
GCM10017557_24150  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
GCM10017557_29260  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
GCM10017557_61620  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
GCM10017557_61610  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
GCM10017557_63900  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
GCM10017557_63890  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
GCM10017557_63910  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
GCM10017557_63920  ectD; ectoine dioxygenase [KO:K10674] [EC:1.14.11.55]
GCM10017557_52960  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sgm00010  Glycolysis / Gluconeogenesis
sgm00020  Citrate cycle (TCA cycle)
sgm00230  Purine metabolism
sgm00250  Alanine, aspartate and glutamate metabolism
sgm00270  Cysteine and methionine metabolism
sgm00290  Valine, leucine and isoleucine biosynthesis
sgm00300  Lysine biosynthesis
sgm00330  Arginine and proline metabolism
sgm00460  Cyanoamino acid metabolism
sgm00470  D-Amino acid metabolism
sgm00564  Glycerophospholipid metabolism
sgm00600  Sphingolipid metabolism
sgm00620  Pyruvate metabolism
sgm00630  Glyoxylate and dicarboxylate metabolism
sgm00640  Propanoate metabolism
sgm00680  Methane metabolism
sgm00860  Porphyrin metabolism
sgm00920  Sulfur metabolism
KO pathway
ko00260   
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