KEGG   PATHWAY: ssc00564
Entry
ssc00564                    Pathway                                
Name
Glycerophospholipid metabolism - Sus scrofa (pig)
Class
Metabolism; Lipid metabolism
Pathway map
ssc00564  Glycerophospholipid metabolism
ssc00564

Module
ssc_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:ssc00564]
ssc_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:ssc00564]
ssc_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:ssc00564]
Other DBs
GO: 0006650
Organism
Sus scrofa (pig) [GN:ssc]
Gene
100037303  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
100151793  SAMD8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:3.1.4.62]
100152017  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100152049  PLPP5; LOW QUALITY PROTEIN: phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100152321  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
100152491  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
100152542  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
100152597  PLA2G12B; group XIIB secretory phospholipase A2-like protein precursor [KO:K01047] [EC:3.1.1.4]
100152643  PCYT1B; choline-phosphate cytidylyltransferase B isoform X4 [KO:K00968] [EC:2.7.7.15]
100152806  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100152836  GPAT4; glycerol-3-phosphate acyltransferase 6 [KO:K13506] [EC:2.3.1.15]
100152927  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100153088  CRLS1; LOW QUALITY PROTEIN: cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
100153250  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
100153506  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial [KO:K01613] [EC:4.1.1.65]
100154368  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
100154792  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
100155983  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
100156253  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
100156632  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100156809  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
100157742  DGKH; LOW QUALITY PROTEIN: diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
100170145  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
100170768  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor [KO:K13509] [EC:2.3.1.51]
100170771  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
100170845  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
100187579  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
100217396  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
100217397  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X4 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100233171  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100233172  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
100233200  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
100303723  LCAT; phosphatidylcholine-sterol acyltransferase precursor [KO:K00650] [EC:2.3.1.43]
100312963  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
100312967  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
100505461  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100511161  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100512162  EPT1; ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) [KO:K00993] [EC:2.7.8.1]
100512194  PCYT1A; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
100512419  PLPP3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
100512584  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100512662  PLA2G2D; group IID secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
100513737  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100513834  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100514108  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100514711  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
100514714  PLA2G2C; LOW QUALITY PROTEIN: putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100514811  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
100515451  PLPP1; phospholipid phosphatase 1 isoform X4 [KO:K01080] [EC:3.1.3.4]
100517106  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100517894  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100518796  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
100519306  PLB1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100519324  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
100519388  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X5 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100519446  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100519533  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
100520687  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100521167  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
100521498  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
100523738  CHPT1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
100524095  PLD4; phospholipase D4 isoform X6 [KO:K16860] [EC:3.1.4.4]
100524266  GPAT3; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
100524423  PNPLA6; LOW QUALITY PROTEIN: neuropathy target esterase [KO:K14676] [EC:3.1.1.5]
100524431  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3 [KO:K00629] [EC:2.3.1.15]
100524478  CHKA; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100526190  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
100621099  ACHE; acetylcholinesterase isoform X3 [KO:K01049] [EC:3.1.1.7]
100621493  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
100621753  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X2 [KO:K06124] [EC:3.1.3.75]
100622701  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
100622761  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
100622861  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
100623089  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100623595  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
100624347  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
100625322  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
100625799  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
100625999  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
100627653  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
100738064  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
102158609  [KO:K06124] [EC:3.1.3.75]
102162529  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110255933  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
110257854  TAZ; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
110258066  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
110259207  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
110259864  [KO:K01047] [EC:3.1.1.4]
110260724  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
110260948  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
110261109  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
396896  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
397097  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
397348  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
397629  GPAM; LOW QUALITY PROTEIN: glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
397654  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
414900  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
445525  PLA2G1B; phospholipase A2, major isoenzyme precursor [KO:K01047] [EC:3.1.1.4]
613128  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
733582  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
ssc00010  Glycolysis / Gluconeogenesis
ssc00260  Glycine, serine and threonine metabolism
ssc00561  Glycerolipid metabolism
ssc00562  Inositol phosphate metabolism
ssc00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
ssc00565  Ether lipid metabolism
ssc00620  Pyruvate metabolism
KO pathway
ko00564   

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