KEGG   PATHWAY: ssn00260
Entry
ssn00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Shigella sonnei Ss046
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ssn00260  Glycine, serine and threonine metabolism
ssn00260

Module
ssn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ssn00260]
ssn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ssn00260]
ssn_M00621  Glycine cleavage system [PATH:ssn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Shigella sonnei Ss046 [GN:ssn]
Gene
SSON_0002  thrA; aspartokinase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
SSON_0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
SSON_0004  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SSON_0124  lpdA; lipoamide dehydrogenase (NADH) [KO:K00382] [EC:1.8.1.4]
SSON_0707  gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]
SSON_0856  ybjU; putative arylsulfatase [KO:K01620] [EC:4.1.2.48]
SSON_0908  serC; 3-phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SSON_1042  ycdW; putative dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SSON_1346  sdaA; L-serine deaminase [KO:K01752] [EC:4.3.1.17]
SSON_1589  ydfG; putative oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SSON_1882  trpB; tryptophan synthase, beta protein [KO:K01696] [EC:4.2.1.20]
SSON_1883  trpA; tryptophan synthase, alpha protein [KO:K01695] [EC:4.2.1.20]
SSON_2457  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
SSON_2634  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SSON_2711  pssA; phosphatidylserine synthase; phospholipid synthesis [KO:K00998] [EC:2.7.8.8]
SSON_2954  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SSON_3056  gcvP; glycine decarboxylase, P protein of glycine cleavage system [KO:K00281] [EC:1.4.4.2]
SSON_3057  gcvH; glycine cleavage system H protein [KO:K02437]
SSON_3058  gcvT; aminomethyltransferase of glycine cleavage system [KO:K00605] [EC:2.1.2.10]
SSON_3065  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SSON_3269  yhaP; putative L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SSON_3274  tdcB; threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
SSON_3279  yhaD; conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
SSON_3673  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SSON_3787  kbl; 2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
SSON_3788  tdh; threonine dehydrogenase [KO:K00060] [EC:1.1.1.103]
SSON_3793  yibO; putative 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SSON_3835  yiaE; putative dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SSON_3943  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
SSON_4114  metL; aspartokinase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
SSON_4202  lysC; aspartokinase III, lysine sensitive [KO:K00928] [EC:2.7.2.4]
SSON_4538  serB; 3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SSON_4545  gpmB; phosphoglyceromutase 2 [KO:K15634] [EC:5.4.2.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ssn00010  Glycolysis / Gluconeogenesis
ssn00020  Citrate cycle (TCA cycle)
ssn00230  Purine metabolism
ssn00250  Alanine, aspartate and glutamate metabolism
ssn00270  Cysteine and methionine metabolism
ssn00290  Valine, leucine and isoleucine biosynthesis
ssn00300  Lysine biosynthesis
ssn00330  Arginine and proline metabolism
ssn00460  Cyanoamino acid metabolism
ssn00470  D-Amino acid metabolism
ssn00564  Glycerophospholipid metabolism
ssn00600  Sphingolipid metabolism
ssn00620  Pyruvate metabolism
ssn00630  Glyoxylate and dicarboxylate metabolism
ssn00640  Propanoate metabolism
ssn00680  Methane metabolism
ssn00860  Porphyrin metabolism
ssn00920  Sulfur metabolism
KO pathway
ko00260   

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