KEGG   PATHWAY: ssyi00260
Entry
ssyi00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Saccharothrix syringae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ssyi00260  Glycine, serine and threonine metabolism
ssyi00260

Module
ssyi_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ssyi00260]
ssyi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ssyi00260]
ssyi_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ssyi00260]
ssyi_M00621  Glycine cleavage system [PATH:ssyi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Saccharothrix syringae [GN:ssyi]
Gene
EKG83_17790  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EKG83_16130  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EKG83_01230  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EKG83_16215  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EKG83_01235  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EKG83_41120  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EKG83_41110  homoserine kinase [KO:K00872] [EC:2.7.1.39]
EKG83_07025  threonine synthase [KO:K01733] [EC:4.2.3.1]
EKG83_10465  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
EKG83_41115  threonine synthase [KO:K01733] [EC:4.2.3.1]
EKG83_45515  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01620] [EC:4.1.2.48]
EKG83_38155  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EKG83_19975  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EKG83_23750  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EKG83_07920  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EKG83_44740  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
EKG83_31795  kinase-like protein [KO:K15918] [EC:2.7.1.31]
EKG83_23270  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EKG83_40295  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EKG83_31760  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
EKG83_02620  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
EKG83_05825  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EKG83_13540  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
EKG83_46370  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
EKG83_46365  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
EKG83_20375  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
EKG83_18535  FAD-binding protein [KO:K00274] [EC:1.4.3.4]
EKG83_36815  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EKG83_38160  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EKG83_07840  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EKG83_41080  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EKG83_36840  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EKG83_41900  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EKG83_24655  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
EKG83_28805  amidinotransferase [KO:K00613] [EC:2.1.4.1]
EKG83_02230  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EKG83_31745  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EKG83_41475  FAD-dependent oxidoreductase [KO:K00301] [EC:1.5.3.1]
EKG83_03690  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
EKG83_40170  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
EKG83_41895  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EKG83_05065  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
EKG83_40485  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
EKG83_20290  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EKG83_38425  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EKG83_20295  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EKG83_38430  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EKG83_28750  pyridoxal-phosphate dependent enzyme [KO:K06001] [EC:4.2.1.20]
EKG83_16105  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
EKG83_16100  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
EKG83_36060  aminotransferase class V-fold PLP-dependent enzyme [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ssyi00010  Glycolysis / Gluconeogenesis
ssyi00020  Citrate cycle (TCA cycle)
ssyi00230  Purine metabolism
ssyi00250  Alanine, aspartate and glutamate metabolism
ssyi00270  Cysteine and methionine metabolism
ssyi00290  Valine, leucine and isoleucine biosynthesis
ssyi00300  Lysine biosynthesis
ssyi00330  Arginine and proline metabolism
ssyi00460  Cyanoamino acid metabolism
ssyi00470  D-Amino acid metabolism
ssyi00564  Glycerophospholipid metabolism
ssyi00600  Sphingolipid metabolism
ssyi00620  Pyruvate metabolism
ssyi00630  Glyoxylate and dicarboxylate metabolism
ssyi00640  Propanoate metabolism
ssyi00680  Methane metabolism
ssyi00860  Porphyrin metabolism
ssyi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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