KEGG   PATHWAY: stro00260
Entry
stro00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces sp. MOE7
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
stro00260  Glycine, serine and threonine metabolism
stro00260

Module
stro_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:stro00260]
stro_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:stro00260]
stro_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:stro00260]
stro_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:stro00260]
stro_M00555  Betaine biosynthesis, choline => betaine [PATH:stro00260]
stro_M00621  Glycine cleavage system [PATH:stro00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces sp. MOE7 [GN:stro]
Gene
STRMOE7_21260  aspartate kinase [KO:K00928] [EC:2.7.2.4]
STRMOE7_13995  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
STRMOE7_21265  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
STRMOE7_26230  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
STRMOE7_26240  homoserine kinase [KO:K00872] [EC:2.7.1.39]
STRMOE7_23100  threonine synthase [KO:K01733] [EC:4.2.3.1]
STRMOE7_26235  threonine synthase [KO:K01733] [EC:4.2.3.1]
STRMOE7_07430  threonine aldolase [KO:K01620] [EC:4.1.2.48]
STRMOE7_26280  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
STRMOE7_26840  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
STRMOE7_23985  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
STRMOE7_02700  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
STRMOE7_31065  glycerate kinase [KO:K00865] [EC:2.7.1.165]
STRMOE7_22795  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
STRMOE7_27075  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
STRMOE7_32505  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
STRMOE7_23365  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
STRMOE7_09965  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
STRMOE7_20095  hydrolase [KO:K01079] [EC:3.1.3.3]
STRMOE7_05320  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
STRMOE7_05325  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
STRMOE7_33755  flavin-containing superfamily amine oxidase [KO:K00274] [EC:1.4.3.4]
STRMOE7_29705  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
STRMOE7_06205  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
STRMOE7_26850  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
STRMOE7_11690  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
STRMOE7_26845  glycine cleavage system protein H [KO:K02437]
STRMOE7_31745  amino acid oxidase [KO:K00273] [EC:1.4.3.3]
STRMOE7_31070  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
STRMOE7_04980  choline oxidase [KO:K17755] [EC:1.1.3.17]
STRMOE7_31465  choline oxidase [KO:K17755] [EC:1.1.3.17]
STRMOE7_04990  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
STRMOE7_31475  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
STRMOE7_27660  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
STRMOE7_27680  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
STRMOE7_23825  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
STRMOE7_05000  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
STRMOE7_02715  ferredoxin [KO:K00302] [EC:1.5.3.24 1.5.3.1]
STRMOE7_02705  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
STRMOE7_02720  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
STRMOE7_02710  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
STRMOE7_16000  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
STRMOE7_20120  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
STRMOE7_26830  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
STRMOE7_05100  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STRMOE7_24575  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
STRMOE7_01070  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
STRMOE7_10965  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
STRMOE7_10970  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
STRMOE7_28230  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
STRMOE7_10255  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
STRMOE7_10250  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
STRMOE7_10260  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
STRMOE7_10265  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
STRMOE7_10825  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
STRMOE7_09825  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
stro00010  Glycolysis / Gluconeogenesis
stro00020  Citrate cycle (TCA cycle)
stro00230  Purine metabolism
stro00250  Alanine, aspartate and glutamate metabolism
stro00270  Cysteine and methionine metabolism
stro00290  Valine, leucine and isoleucine biosynthesis
stro00300  Lysine biosynthesis
stro00330  Arginine and proline metabolism
stro00460  Cyanoamino acid metabolism
stro00470  D-Amino acid metabolism
stro00564  Glycerophospholipid metabolism
stro00600  Sphingolipid metabolism
stro00620  Pyruvate metabolism
stro00630  Glyoxylate and dicarboxylate metabolism
stro00640  Propanoate metabolism
stro00680  Methane metabolism
stro00860  Porphyrin metabolism
stro00920  Sulfur metabolism
KO pathway
ko00260   
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