KEGG   PATHWAY: tfn04530
Entry
tfn04530                    Pathway                                
Name
Tight junction - Trachypithecus francoisi (Francois's langur)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tfn04530  Tight junction
tfn04530

Other DBs
GO: 0005923
Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117062121  [KO:K05756]
117062364  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
117062719  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
117062886  CLDN23; claudin-23 [KO:K06087]
117063458  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
117063600  CLDN10; claudin-10 isoform X1 [KO:K06087]
117063724  [KO:K04393]
117064083  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
117064107  [KO:K12757]
117064108  MYL12B; myosin regulatory light chain 12B [KO:K12757]
117064197  PARD6G; LOW QUALITY PROTEIN: partitioning defective 6 homolog gamma [KO:K06093]
117065053  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117065147  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
117065222  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
117065223  OCLN; occludin isoform X1 [KO:K06088]
117065429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117065606  SYNPO; synaptopodin isoform X1 [KO:K21112]
117065664  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
117065862  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117065874  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
117065906  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
117066646  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
117066682  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
117066827  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117067088  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117067713  MYH10; myosin-10 isoform X1 [KO:K10352]
117067805  CLDN7; claudin-7 [KO:K06087]
117068495  PCNA; proliferating cell nuclear antigen [KO:K04802]
117068731  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
117068749  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
117068925  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
117069415  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
117069442  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
117070267  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
117070467  [KO:K12751]
117070546  RAB8B; ras-related protein Rab-8B [KO:K07902]
117070596  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
117070610  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
117070956  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
117071106  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
117072016  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117072017  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117072265  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
117072349  CLDN15; claudin-15 [KO:K06087]
117072543  CLDN4; claudin-4 [KO:K06087]
117072720  [KO:K07374]
117072721  ACTB; actin, cytoplasmic 1 [KO:K05692]
117072767  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
117072791  CLDN3; claudin-3 [KO:K06087]
117073087  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
117073479  CLDN12; claudin-12 [KO:K06087]
117073515  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
117073672  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117073751  [KO:K07374]
117074239  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117074389  F11R; junctional adhesion molecule A [KO:K06089]
117074400  CGN; cingulin [KO:K06102]
117074523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
117074657  CRB3; protein crumbs homolog 3 [KO:K06090]
117074695  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
117074866  RAB8A; ras-related protein Rab-8A [KO:K07901]
117075415  [KO:K12751]
117075492  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
117075735  [KO:K05756]
117075972  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
117076028  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
117076115  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
117076307  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117076380  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
117076381  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
117076383  [KO:K06448]
117076384  CD1C; T-cell surface glycoprotein CD1c isoform X1 [KO:K06448]
117076385  [KO:K06448]
117076386  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
117076549  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
117076725  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
117077194  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
117077350  RAP2C; LOW QUALITY PROTEIN: ras-related protein Rap-2c [KO:K07839]
117077392  CLDN2; claudin-2 [KO:K06087]
117077445  MSN; moesin isoform X1 [KO:K05763]
117077580  AMOT; LOW QUALITY PROTEIN: angiomotin [KO:K16819]
117078099  CLDN34; claudin-34 [KO:K06087]
117078274  WAS; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein [KO:K05747]
117078986  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
117079987  RDX; radixin isoform X1 [KO:K05762]
117080053  [KO:K12751]
117080182  CLDN25; putative claudin-25 [KO:K06087]
117080857  CTTN; src substrate cortactin isoform X1 [KO:K06106]
117081231  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
117081433  RHOA; transforming protein RhoA [KO:K04513]
117081453  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
117081518  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
117081764  JAM3; junctional adhesion molecule C [KO:K06785]
117081956  [KO:K05692]
117082160  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
117082443  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
117082567  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
117082638  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
117082864  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117083004  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117083098  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
117083152  [KO:K05692]
117083219  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
117083436  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
117083715  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117083723  CLDN11; claudin-11 isoform X1 [KO:K06087]
117084141  CLDN18; claudin-18 isoform X1 [KO:K06087]
117084160  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
117084379  CLDN1; claudin-1 [KO:K06087]
117084380  CLDN16; claudin-16 [KO:K06087]
117084441  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
117084835  [KO:K07374]
117085110  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
117085362  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117085754  [KO:K04392]
117086175  CLDN22; LOW QUALITY PROTEIN: claudin-22 [KO:K06087]
117086177  [KO:K06087]
117087264  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
117087476  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
117087546  [KO:K07374]
117088009  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
117088453  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
117089314  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
117089416  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117089862  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
117089947  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
117089948  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
117090172  [KO:K07374]
117090173  TUBA1C; tubulin alpha-1C chain [KO:K07374]
117090175  [KO:K07374]
117090183  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
117090546  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
117090727  [KO:K06274]
117091405  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117091419  SYMPK; symplekin [KO:K06100]
117091620  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
117091972  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117091985  JUN; transcription factor AP-1 [KO:K04448]
117092002  PATJ; inaD-like protein isoform X1 [KO:K06092]
117092158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117092482  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
117093160  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117093432  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
117093595  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
117093681  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
117093902  CLDN19; claudin-19 isoform X1 [KO:K06087]
117094375  [KO:K05692]
117094495  [KO:K07374]
117094511  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
117094538  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117094544  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117094651  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
117095103  ACTR3; actin-related protein 3 [KO:K18584]
117095398  [KO:K06087]
117095626  JAM2; junctional adhesion molecule B [KO:K06735]
117095660  CLDN17; claudin-17 [KO:K06087]
117095661  CLDN8; claudin-8 [KO:K06087]
117095685  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
117095741  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
117095756  CLDN14; LOW QUALITY PROTEIN: claudin-14 [KO:K06087]
117095959  MYH9; myosin-9 isoform X1 [KO:K10352]
117096039  CLDN5; claudin-5 [KO:K06087]
117096062  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
117096158  NF2; merlin isoform X1 [KO:K16684]
117096761  IGSF5; LOW QUALITY PROTEIN: immunoglobulin superfamily member 5 [KO:K06786]
117096874  AFDN; afadin isoform X1 [KO:K05702]
117097143  BVES; blood vessel epicardial substance [KO:K21108]
117097223  EZR; ezrin isoform X1 [KO:K08007]
117097251  [KO:K12751]
117097252  CLDN20; claudin-20 [KO:K06087]
117097478  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117097612  MYH11; myosin-11 isoform X1 [KO:K10352]
117097763  CLDN6; claudin-6 [KO:K06087]
117097765  CLDN9; claudin-9 [KO:K06087]
117098495  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
117098498  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
117098531  RAB13; LOW QUALITY PROTEIN: ras-related protein Rab-13 [KO:K06109]
117098584  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
117098858  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
117099196  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
117099238  [KO:K12751]
117099748  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
tfn04520  Adherens junction
tfn04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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