KEGG   PATHWAY: uah03083
Entry
uah03083                    Pathway                                
Name
Polycomb repressive complex - Ursus arctos (brown bear)
Class
Genetic Information Processing; Chromosome
Pathway map
uah03083  Polycomb repressive complex
uah03083

Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113241150  SFMBT2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
113241342  BMI1; polycomb complex protein BMI-1 [KO:K11459]
113241452  EZH2; histone-lysine N-methyltransferase EZH2 isoform X2 [KO:K11430] [EC:2.1.1.356]
113241736  L3MBTL2; lethal(3)malignant brain tumor-like protein 2 [KO:K24387]
113241737  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
113241765  CBX7; chromobox protein homolog 7 isoform X1 [KO:K11454]
113241766  CBX6; chromobox protein homolog 6 [KO:K11453]
113241999  MGA; MAX gene-associated protein isoform X2 [KO:K23399]
113242235  YY2; transcription factor YY2 [KO:K09201]
113242257  SCML2; sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
113242261  SCML1; sex comb on midleg-like protein 1 isoform X1 [KO:K11464]
113242267  RBBP7; histone-binding protein RBBP7 isoform X1 [KO:K11659]
113243157  PCGF5; polycomb group RING finger protein 5 isoform X3 [KO:K11489]
113243635  PCGF1; polycomb group RING finger protein 1 isoform X3 [KO:K11487]
113243794  RING1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
113243808  PHF1; PHD finger protein 1 isoform X1 [KO:K11467]
113244041  KDM2A; lysine-specific demethylase 2A [KO:K10276] [EC:1.14.11.27]
113244467  FOXK2; forkhead box protein K2 [KO:K09404]
113244543  CBX4; E3 SUMO-protein ligase CBX4 isoform X1 [KO:K11452] [EC:2.3.2.-]
113244544  CBX8; chromobox protein homolog 8 [KO:K11455]
113244545  CBX2; chromobox protein homolog 2 [KO:K11451]
113245624  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
113245681  PCGF3; polycomb group RING finger protein 3 isoform X1 [KO:K11488]
113246305  MAX; protein max isoform X1 [KO:K04453]
113247569  TFDP1; transcription factor Dp-1 [KO:K04683]
113250905  MBD5; methyl-CpG-binding domain protein 5 isoform X1 [KO:K23219]
113251773  LCOR; ligand-dependent corepressor isoform X1 [KO:K26260]
113251887  PCGF6; polycomb group RING finger protein 6 isoform X1 [KO:K11470]
113252248  WDR5B; WD repeat-containing protein 5B [KO:K14963]
113253201  ASXL3; putative Polycomb group protein ASXL3 [KO:K11471]
113253231  L3MBTL4; lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
113254401  MTF2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
113254820  SCMH1; polycomb protein SCMH1 isoform X13 [KO:K11461]
113255235  PHC3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
113256377  MBD6; methyl-CpG-binding domain protein 6 isoform X1 [KO:K26585]
113256949  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
113256972  SFMBT1; scm-like with four MBT domains protein 1 isoform X1 [KO:K26269]
113257084  RYBP; RING1 and YY1-binding protein [KO:K11469]
113257725  YAF2; YY1-associated factor 2 isoform X1 [KO:K11468]
113257831  AEBP2; zinc finger protein AEBP2 [KO:K17452]
113257919  PHC1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
113258479  ASXL1; polycomb group protein ASXL1 isoform X1 [KO:K11471]
113258620  L3MBTL1; lethal(3)malignant brain tumor-like protein 1 isoform X2 [KO:K24387]
113259064  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
113259438  L3MBTL3; lethal(3)malignant brain tumor-like protein 3 isoform X1 [KO:K24387]
113260393  TEX10; testis-expressed protein 10 isoform X1 [KO:K14827]
113261736  SKP1; S-phase kinase-associated protein 1 isoform X2 [KO:K03094]
113261778  CBX3; chromobox protein homolog 3 [KO:K11586]
113261812  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
113262747  RNF2; E3 ubiquitin-protein ligase RING2 isoform X3 [KO:K10695] [EC:2.3.2.27]
113263096  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X8 [KO:K06689] [EC:2.3.2.23]
113264485  JARID2; protein Jumonji isoform X1 [KO:K11478]
113264707  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
113264802  USP45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
113265292  DCAF7; DDB1- and CUL4-associated factor 7 [KO:K11805]
113265406  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
113265541  PCGF2; polycomb group RING finger protein 2 isoform X1 [KO:K11460]
113265545  EPOP; elongin BC and Polycomb repressive complex 2-associated protein [KO:K26259]
113265869  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
113266350  PHF19; PHD finger protein 19 isoform X3 [KO:K11486]
113266583  WDR5; WD repeat-containing protein 5 isoform X1 [KO:K14963]
113266944  KDM2B; lysine-specific demethylase 2B isoform X2 [KO:K10276] [EC:1.14.11.27]
113267275  YY1; transcriptional repressor protein YY1 [KO:K09201]
113267532  FOXK1; forkhead box protein K1 [KO:K09404]
113267687  USP16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
113267693  FBRS; LOW QUALITY PROTEIN: probable fibrosin-1 [KO:K26253]
113267983  AUTS2; autism susceptibility gene 2 protein isoform X3 [KO:K23214]
113268347  RBBP4; histone-binding protein RBBP4 [KO:K10752]
113268357  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
113268999  SUZ12; polycomb protein SUZ12 isoform X1 [KO:K11463]
113269401  EED; polycomb protein EED isoform X3 [KO:K11462]
113269983  E2F6; transcription factor E2F6 isoform X1 [KO:K09390]
113270731  ASXL2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
113270814  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [KO:K11838] [EC:3.4.19.12]
113270858  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
113270949  BCORL1; BCL-6 corepressor-like protein 1 isoform X1 [KO:K26199]
113271177  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 143:511-527 (2024)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   

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