Entry Name Progesterone-mediated oocyte maturation - Xiphophorus couchianus (Monterrey platyfish)
Description Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map xco04914 Progesterone-mediated oocyte maturation
Other DBs Organism Xiphophorus couchianus (Monterrey platyfish) [GN:
xco ]
Gene 114137548 anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456 ]
114137886 cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602 ]
114138257 anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348 ]
114142833 cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602 ]
114144651 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
114145249 mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679 ]
114147800 mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
114149262 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114150896 cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602 ]
114152790 cpeb4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602 ]
114153492 cdc23; cell division cycle protein 23 homolog isoform X1 [KO:K03355 ]
114156785 mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537 ]
114156935 pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633 ] [EC:2.7.11.1 ]
114156986 anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357 ]
114160217 cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350 ]
114161826 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference Authors Schmitt A, Nebreda AR.
Title Signalling pathways in oocyte meiotic maturation.
Journal J Cell Sci 115:2457-9 (2002)
Reference Authors Cato AC, Nestl A, Mink S.
Title Rapid actions of steroid receptors in cellular signaling pathways.
Journal Reference Authors Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
Title The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Journal Reference Authors Nebreda AR, Ferby I.
Title Regulation of the meiotic cell cycle in oocytes.
Journal Reference Authors Ferrell JE Jr.
Title Xenopus oocyte maturation: new lessons from a good egg.
Journal Reference Authors Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Title Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Journal Reference Authors Duckworth BC, Weaver JS, Ruderman JV.
Title G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Journal Reference Authors Abrieu A, Doree M, Fisher D.
Title The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Journal J Cell Sci 114:257-67 (2001)
Related KO pathway
