KEGG   PATHWAY: xco04010
Entry
xco04010                    Pathway                                
Name
MAPK signaling pathway - Xiphophorus couchianus (Monterrey platyfish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
xco04010  MAPK signaling pathway
xco04010

Other DBs
GO: 0000165
Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114133159  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
114133190  crk; adapter molecule crk isoform X1 [KO:K04438]
114133278  mecom; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
114133417  [KO:K04858]
114133467  [KO:K04350]
114133637  nf1; neurofibromin [KO:K08052]
114133823  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
114133902  [KO:K04410] [EC:2.7.11.1]
114133938  [KO:K04427] [EC:2.7.11.25]
114133978  [KO:K04379]
114134047  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114134066  [KO:K04402]
114134077  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114134112  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
114134115  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114134163  [KO:K05462]
114134217  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
114134221  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
114134235  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
114134421  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
114134500  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114134657  [KO:K04453]
114134789  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
114134838  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
114134848  [KO:K16859]
114134863  [KO:K08774]
114134914  [KO:K04860]
114135049  [KO:K04859]
114135071  [KO:K04441] [EC:2.7.11.24]
114135246  [KO:K04393]
114135258  [KO:K05084] [EC:2.7.10.1]
114135267  [KO:K04423] [EC:2.7.11.25]
114135373  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114135476  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114135515  [KO:K04851]
114135604  [KO:K04411]
114135669  [KO:K04376]
114135726  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
114135737  hras; GTPase HRas [KO:K02833]
114135748  [KO:K04353]
114135771  [KO:K04859]
114135929  [KO:K05103] [EC:2.7.10.1]
114135944  [KO:K04444] [EC:2.7.11.1]
114136008  [KO:K04377]
114136162  [KO:K04444] [EC:2.7.11.1]
114136191  [KO:K05465]
114136221  [KO:K04441] [EC:2.7.11.24]
114136232  [KO:K04434]
114136284  [KO:K04465]
114136304  [KO:K02582]
114136421  [KO:K04361] [EC:2.7.10.1]
114136428  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114136644  hgf; hepatocyte growth factor [KO:K05460]
114136809  [KO:K04421] [EC:2.7.11.25]
114136895  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114136904  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114136905  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
114136908  [KO:K05092] [EC:2.7.10.1]
114137042  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
114137073  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
114137130  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
114137520  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
114137530  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
114137568  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
114137669  [KO:K04440] [EC:2.7.11.24]
114137786  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
114137823  [KO:K04390]
114137948  [KO:K04456] [EC:2.7.11.1]
114137969  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
114138026  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
114138146  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
114138183  srf; serum response factor isoform X1 [KO:K04378]
114138204  [KO:K04865]
114138295  [KO:K05093] [EC:2.7.10.1]
114138308  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
114138398  angpt2; angiopoietin-2 [KO:K05466]
114138537  [KO:K04467] [EC:2.7.11.10]
114138554  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
114138604  [KO:K04358]
114138665  egf; pro-epidermal growth factor [KO:K04357]
114138676  fgf16; fibroblast growth factor 16 [KO:K04358]
114138797  fgf18; fibroblast growth factor 18 isoform X1 [KO:K04358]
114138894  rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114139005  [KO:K04389]
114139012  [KO:K04407] [EC:2.7.11.1]
114139086  [KO:K04358]
114139089  fgf2; fibroblast growth factor 2 [KO:K18497]
114139113  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114139131  [KO:K04440] [EC:2.7.11.24]
114139185  [KO:K18496]
114139226  [KO:K04358]
114139259  [KO:K05096] [EC:2.7.10.1]
114139330  [KO:K04348] [EC:3.1.3.16]
114139363  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
114139399  vegfb; vascular endothelial growth factor B [KO:K16858]
114139436  [KO:K13376]
114139461  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114139478  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114139479  [KO:K05090] [EC:2.7.10.1]
114139499  [KO:K02187] [EC:3.4.22.56]
114139572  pdgfc; platelet-derived growth factor C [KO:K05450]
114139621  [KO:K04526]
114139721  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
114140233  [KO:K04730] [EC:2.7.11.1]
114140408  [KO:K04465]
114140444  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114140552  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
114140577  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114140702  [KO:K05449]
114140864  [KO:K04353]
114140872  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114140993  [KO:K04426] [EC:2.7.11.25]
114140996  [KO:K04375]
114141072  [KO:K04853]
114141096  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
114141251  [KO:K04853]
114141624  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114141649  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114141752  [KO:K04437]
114141833  [KO:K03283]
114141838  [KO:K05462]
114141948  [KO:K19663] [EC:2.7.11.13]
114142014  [KO:K05462]
114142015  efna1; ephrin-A1 [KO:K05462]
114142025  [KO:K02583]
114142233  [KO:K04441] [EC:2.7.11.24]
114142255  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
114142284  [KO:K04393]
114142329  [KO:K04873]
114142375  [KO:K04872]
114142411  [KO:K04381]
114142519  [KO:K05459]
114142698  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
114142760  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114142761  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114142877  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
114143027  rras2; ras-related protein R-Ras2 [KO:K07830]
114143057  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114143064  [KO:K05087] [EC:2.7.10.1]
114143095  [KO:K04861]
114143128  fgf3; fibroblast growth factor 3 [KO:K04358]
114143132  fgf19; fibroblast growth factor 19 [KO:K22603]
114143136  fgf4; fibroblast growth factor 4 [KO:K04358]
114143167  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114143267  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
114143305  [KO:K04349]
114143332  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
114143619  fgf7; fibroblast growth factor 7 [KO:K04358]
114143627  [KO:K04373] [EC:2.7.11.1]
114143776  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114143981  [KO:K04358]
114144103  [KO:K04378]
114144177  [KO:K05091] [EC:2.7.10.1]
114144243  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
114144259  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114144260  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
114144319  [KO:K04456] [EC:2.7.11.1]
114144355  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114144382  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
114144415  [KO:K07860]
114144559  epha2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
114144619  [KO:K04393]
114144636  [KO:K04441] [EC:2.7.11.24]
114144649  prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114144862  [KO:K04358]
114145015  [KO:K04388] [EC:2.7.11.30]
114145100  [KO:K04856]
114145108  [KO:K17386]
114145177  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114145269  [KO:K04359]
114145272  [KO:K25416]
114145292  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114145343  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
114145353  [KO:K04860]
114145365  [KO:K04867]
114145370  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114145380  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
114145403  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114145410  vegfc; vascular endothelial growth factor C [KO:K05449]
114145429  [KO:K04374]
114145501  [KO:K19662] [EC:2.7.11.13]
114145506  gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
114145510  [KO:K04868]
114145641  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
114145767  [KO:K25415]
114145916  jun; transcription factor AP-1 [KO:K04448]
114146044  [KO:K03283]
114146318  [KO:K04377]
114146401  [KO:K04345] [EC:2.7.11.11]
114146472  insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
114146596  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114146626  [KO:K04852]
114146747  [KO:K05084] [EC:2.7.10.1]
114146970  [KO:K04347]
114146994  [KO:K04449]
114147068  [KO:K04424] [EC:2.7.11.25]
114147177  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
114147219  [KO:K25414]
114147890  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114147892  [KO:K07830]
114147906  [KO:K04441] [EC:2.7.11.24]
114147959  [KO:K04865]
114148083  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114148180  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114148299  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114148301  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
114148358  mras; ras-related protein M-Ras [KO:K07831]
114148398  [KO:K04864]
114148479  [KO:K05085] [EC:2.7.10.1]
114148573  pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
114148648  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
114148676  map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
114148728  [KO:K04386]
114148813  [KO:K04407] [EC:2.7.11.1]
114149066  [KO:K04519]
114149078  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
114149095  [KO:K04455]
114149230  [KO:K03173] [EC:2.3.2.27]
114149259  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114149382  [KO:K12326]
114149405  [KO:K04454]
114149406  [KO:K04348] [EC:3.1.3.16]
114149532  crkl; crk-like protein [KO:K04438]
114149547  [KO:K04362] [EC:2.7.10.1]
114149580  [KO:K04429] [EC:2.7.11.1]
114149726  [KO:K03173] [EC:2.3.2.27]
114149751  [KO:K04849]
114149782  [KO:K04674] [EC:2.7.11.30]
114149806  [KO:K05462]
114149816  [KO:K04402]
114149964  [KO:K04360] [EC:2.7.10.1]
114150017  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114150230  [KO:K04358]
114150361  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114150417  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114150432  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
114150449  [KO:K04358]
114150504  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
114150578  [KO:K04527] [EC:2.7.10.1]
114150820  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
114150831  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114150885  rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114150888  [KO:K04347]
114151094  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
114151105  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114151106  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114151148  jund; transcription factor jun-D [KO:K04449]
114151198  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
114151264  [KO:K04448]
114151419  [KO:K04392]
114151420  [KO:K04392]
114151421  [KO:K04392]
114151477  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114151556  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114151722  [KO:K04440] [EC:2.7.11.24]
114151734  [KO:K04430] [EC:2.7.12.2]
114151820  [KO:K04854]
114151841  [KO:K04466] [EC:2.7.11.25]
114151890  [KO:K04467] [EC:2.7.11.10]
114151903  dusp3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114151970  [KO:K04461] [EC:3.1.3.16]
114152030  [KO:K04380]
114152068  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114152147  [KO:K02583]
114152162  [KO:K04433] [EC:2.7.12.2]
114152283  [KO:K02582]
114152372  [KO:K22428]
114152389  [KO:K04358]
114152588  [KO:K04856]
114152626  fgf1; fibroblast growth factor 1 [KO:K18496]
114152833  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
114152842  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
114152956  [KO:K04438]
114152958  hspb1; heat shock protein beta-1 [KO:K04455]
114152980  [KO:K03283]
114153115  [KO:K05089] [EC:2.7.10.1]
114153116  [KO:K05090] [EC:2.7.10.1]
114153231  [KO:K22429]
114153347  [KO:K04348] [EC:3.1.3.16]
114153593  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
114153736  [KO:K04457] [EC:3.1.3.16]
114153755  ins; insulin isoform X1 [KO:K04526]
114153953  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114153988  [KO:K04519]
114154047  fgf5; fibroblast growth factor 5 [KO:K04358]
114154066  [KO:K05452]
114154092  [KO:K04455]
114154115  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114154145  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114154160  fgf10; fibroblast growth factor 10 [KO:K04358]
114154182  fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
114154183  fgf17; fibroblast growth factor 17 [KO:K04358]
114154220  efna5; ephrin-A5 isoform X1 [KO:K05462]
114154312  [KO:K04348] [EC:3.1.3.16]
114154407  [KO:K08845] [EC:2.7.11.1]
114154589  rasa1; ras GTPase-activating protein 1 [KO:K04352]
114154613  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
114154846  taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
114154958  [KO:K12326]
114155101  [KO:K03173] [EC:2.3.2.27]
114155107  [KO:K09782]
114155108  [KO:K09784]
114155120  [KO:K04519]
114155127  [KO:K04849]
114155146  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
114155224  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114155243  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
114155406  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
114155407  [KO:K17333]
114155490  [KO:K04358]
114155778  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114155961  [KO:K04873]
114155962  [KO:K04872]
114155967  [KO:K05461]
114156039  [KO:K04446]
114156104  [KO:K04393]
114156140  [KO:K04388] [EC:2.7.11.30]
114156148  [KO:K05462]
114156369  [KO:K02308]
114156456  [KO:K04381]
114156470  [KO:K03156]
114156567  kras; GTPase KRas isoform X1 [KO:K07827]
114156581  [KO:K05466]
114156593  [KO:K04871]
114156604  [KO:K05462]
114156609  angpt1; angiopoietin-1 [KO:K05465]
114157052  [KO:K04419] [EC:2.7.11.25]
114157055  [KO:K04348] [EC:3.1.3.16]
114157072  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114157257  [KO:K05087] [EC:2.7.10.1]
114157395  [KO:K04735]
114157439  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
114157502  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
114157515  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
114157824  tp53; cellular tumor antigen p53 [KO:K04451]
114157959  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
114158068  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114158125  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
114158134  [KO:K16859]
114158174  [KO:K13377]
114158175  [KO:K04379]
114158176  [KO:K04379]
114158479  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114158518  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114158538  max; protein max isoform X1 [KO:K04453]
114158595  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
114158781  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
114158858  igf2; insulin-like growth factor II [KO:K13769]
114159406  [KO:K04866]
114159409  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114159417  [KO:K03283]
114159540  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
114159562  [KO:K03283]
114159563  [KO:K04468] [EC:2.7.11.24]
114159632  [KO:K04344]
114159700  [KO:K04374]
114159753  [KO:K04345] [EC:2.7.11.11]
114159788  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
114159818  [KO:K02583]
114159851  [KO:K02677] [EC:2.7.11.13]
114159852  [KO:K04870]
114159893  [KO:K04855]
114159895  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114159931  [KO:K04349]
114159938  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
114160036  [KO:K07827]
114160039  [KO:K04371] [EC:2.7.11.24]
114160045  grb2; growth factor receptor-bound protein 2 [KO:K04364]
114160070  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
114160134  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
114160156  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114160172  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
114160221  [KO:K04433] [EC:2.7.12.2]
114160257  [KO:K04466] [EC:2.7.11.25]
114160370  [KO:K04380]
114160398  [KO:K04392]
114160485  [KO:K04867]
114160515  [KO:K04869]
114160618  [KO:K04441] [EC:2.7.11.24]
114160677  [KO:K05461]
114160855  [KO:K04858]
114160874  fgf23; fibroblast growth factor 23 [KO:K22428]
114160876  [KO:K04358]
114160879  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114160961  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
114160998  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
114161013  [KO:K04441] [EC:2.7.11.24]
114161014  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
114161058  ntf3; neurotrophin-3 [KO:K04356]
114161125  [KO:K05460]
114161185  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
114161254  [KO:K04850]
114161374  [KO:K04457] [EC:3.1.3.16]
114161404  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
114161405  [KO:K13375]
114161475  [KO:K03283]
114161580  [KO:K07836]
114161603  [KO:K04456] [EC:2.7.11.1]
114161670  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
114161686  [KO:K09253]
114161721  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114161734  [KO:K04439]
114161830  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
114161884  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
114161894  rasa2; ras GTPase-activating protein 2 [KO:K08053]
114161941  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114162009  pdgfd; platelet-derived growth factor D [KO:K05450]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
xco04070  Phosphatidylinositol signaling system
xco04110  Cell cycle
xco04115  p53 signaling pathway
xco04210  Apoptosis
xco04310  Wnt signaling pathway
KO pathway
ko04010   

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