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ENTRY	nt06522
Name	mTOR signaling
Category	Pathway view; Signal transduction
Pathway	hsa04150 mTOR signaling pathway
Disease	H01928 Smith-Kingsmore syndrome
Display	drug-target relation   disease type

N01576    (STRADA/B+STK11) → PRKAA1/2 → (TSC1/2+TBC1D7)     PMSE STRADA*     PJS STK11* N01575            (TSC1/2+TBC1D7) ⊣ RHEB → mTORC1     TSC1/LAM/FCDT         TSC1*     AML/SEGA         TSC1*     TSC2/LAM/FCDT         TSC2*     AML/SEGA         TSC2*     MGCPH         TBC1D7*     SKS/FCDT                 mTOR* ↗ N00388    HCMV     UL38 ⊣ (TSC1+TSC2) N00357    HPV     (E6+UBE3A) ⊣ (TSC1+TSC2) N00584    HSV     US3 ⊣ (TSC1+TSC2) N01578            (NPRL2/3+DEPDC5) ⊣ RRAGA/B/C/D → mTORC1     FFEVF1         DEPDC5*     FFEVF2         NRPL2*     FFEVF3         NPRL3*     LNGODS             RRAGC* ↗     HOMG             RRAGD* ↗ N01584        (SLC7A5+SLC3A2) → FLCN → RRAGA/B/C/D → mTORC1     BHD         FLCN*

		Disease name	Disease category
PMSE	H01112	Polyhydramnios, megalencephaly, and symptomatic epilepsy	Congenital malformation
PJS	H00666	Peutz-Jeghers syndrome	Digestive system disease
TSC1/LAM/FCDT	H00915	Tuberous sclerosis complex	Congenital malformation
	H00896	Lymphangioleiomyomatosis	Respiratory system disease
	H01251	Focal cortical dysplasia of Taylor	Congenital malformation
AML/SEGA	H01691	Renal angiomyolipoma	Neoplasm
	H01692	Subependymal giant cell astrocytoma	Nervous system disease
TSC2/LAM/FCDT	H00915	Tuberous sclerosis complex	Congenital malformation
	H00896	Lymphangioleiomyomatosis	Respiratory system disease
	H01251	Focal cortical dysplasia of Taylor	Congenital malformation
MGCPH	H02446	Autosomal recessive macrocephaly/megalencephaly syndrome	Congenital malformation
SKS/FCDT	H01928	Smith-Kingsmore syndrome	Congenital malformation
	H01251	Focal cortical dysplasia of Taylor	Congenital malformation
HCMV	H00368	Cytomegalovirus infection	Viral infectious disease
HPV	H00030	Cervical cancer	Cancer
HSV	H00365	Herpes simplex virus infection	Viral infectious disease
FFEVF1	H02214	Familial focal epilepsy with variable foci	Nervous system disease
FFEVF2	H02214	Familial focal epilepsy with variable foci	Nervous system disease
FFEVF3	H02214	Familial focal epilepsy with variable foci	Nervous system disease
LNGODS	H02697	Long-Olsen-Distelmaier syndrome	Congenital malformation
HOMG	H01210	Hypomagnesemia	Inherited metabolic disorder
BHD	H00818	Birt-Hogg-Dube syndrome	Congenital malformation