KEGG   Homo sapiens (human): 2475
Entry
2475              CDS       T01001                                 
Symbol
MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
Name
(RefSeq) mechanistic target of rapamycin kinase
  KO
K07203  serine/threonine-protein kinase mTOR [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04012  ErbB signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04371  Apelin signaling pathway
hsa04613  Neutrophil extracellular trap formation
hsa04630  JAK-STAT signaling pathway
hsa04659  Th17 cell differentiation
hsa04714  Thermogenesis
hsa04910  Insulin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04935  Growth hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05221  Acute myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06214  PI3K signaling (cancer)
nt06224  CXCR signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06270  Breast cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N01065  Mutation-activated RET to PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Disease
H01251  Focal cortical dysplasia of Taylor
H01928  Smith-Kingsmore syndrome
Drug target
Apitolisib: D10543
Bimiralisib: D11440
Dactolisib (DG01826): D10552 D10616
Everolimus: D02714<JP/US>
Gedatolisib: D10635
Olcorolimus: D10076
Omipalisib: D10718
Onatasertib: D11663
Paxalisib: D11869
Ridaforolimus: D08900
Samotolisib: D11501
Sirolimus: D00753<JP/US>
Temsirolimus: D06068<JP/US>
Voxtalisib: D11727
Zotarolimus: D06669
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    2475 (MTOR)
   04371 Apelin signaling pathway
    2475 (MTOR)
   04630 JAK-STAT signaling pathway
    2475 (MTOR)
   04066 HIF-1 signaling pathway
    2475 (MTOR)
   04072 Phospholipase D signaling pathway
    2475 (MTOR)
   04151 PI3K-Akt signaling pathway
    2475 (MTOR)
   04152 AMPK signaling pathway
    2475 (MTOR)
   04150 mTOR signaling pathway
    2475 (MTOR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    2475 (MTOR)
   04136 Autophagy - other
    2475 (MTOR)
  09143 Cell growth and death
   04218 Cellular senescence
    2475 (MTOR)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    2475 (MTOR)
   04659 Th17 cell differentiation
    2475 (MTOR)
  09152 Endocrine system
   04910 Insulin signaling pathway
    2475 (MTOR)
   04920 Adipocytokine signaling pathway
    2475 (MTOR)
   04935 Growth hormone synthesis, secretion and action
    2475 (MTOR)
   04919 Thyroid hormone signaling pathway
    2475 (MTOR)
  09149 Aging
   04211 Longevity regulating pathway
    2475 (MTOR)
   04213 Longevity regulating pathway - multiple species
    2475 (MTOR)
  09159 Environmental adaptation
   04714 Thermogenesis
    2475 (MTOR)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2475 (MTOR)
   05206 MicroRNAs in cancer
    2475 (MTOR)
   05205 Proteoglycans in cancer
    2475 (MTOR)
   05207 Chemical carcinogenesis - receptor activation
    2475 (MTOR)
   05230 Central carbon metabolism in cancer
    2475 (MTOR)
   05231 Choline metabolism in cancer
    2475 (MTOR)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    2475 (MTOR)
  09162 Cancer: specific types
   05210 Colorectal cancer
    2475 (MTOR)
   05212 Pancreatic cancer
    2475 (MTOR)
   05225 Hepatocellular carcinoma
    2475 (MTOR)
   05226 Gastric cancer
    2475 (MTOR)
   05214 Glioma
    2475 (MTOR)
   05221 Acute myeloid leukemia
    2475 (MTOR)
   05215 Prostate cancer
    2475 (MTOR)
   05224 Breast cancer
    2475 (MTOR)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2475 (MTOR)
   05168 Herpes simplex virus 1 infection
    2475 (MTOR)
   05163 Human cytomegalovirus infection
    2475 (MTOR)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2475 (MTOR)
   05165 Human papillomavirus infection
    2475 (MTOR)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    2475 (MTOR)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2475 (MTOR)
   05014 Amyotrophic lateral sclerosis
    2475 (MTOR)
   05016 Huntington disease
    2475 (MTOR)
   05017 Spinocerebellar ataxia
    2475 (MTOR)
   05022 Pathways of neurodegeneration - multiple diseases
    2475 (MTOR)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    2475 (MTOR)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    2475 (MTOR)
   04931 Insulin resistance
    2475 (MTOR)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    2475 (MTOR)
   01522 Endocrine resistance
    2475 (MTOR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2475 (MTOR)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2475 (MTOR)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     2475 (MTOR)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   2475 (MTOR)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    2475 (MTOR)
   mTORC2 complex
    2475 (MTOR)
SSDB
Motif
Pfam: FAT PI3_PI4_kinase mTOR_dom FRB_dom FATC HEAT_EZ HEAT_2 IFRD UME EPSP_synthase
Other DBs
NCBI-GeneID: 2475
NCBI-ProteinID: NP_004949
OMIM: 601231
HGNC: 3942
Ensembl: ENSG00000198793
UniProt: P42345
Structure
LinkDB
Position
1:complement(11106535..11262551)
AA seq 2549 aa
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 7650 nt   +upstreamnt  +downstreamnt
atgcttggaaccggacctgccgccgccaccaccgctgccaccacatctagcaatgtgagc
gtcctgcagcagtttgccagtggcctaaagagccggaatgaggaaaccagggccaaagcc
gccaaggagctccagcactatgtcaccatggaactccgagagatgagtcaagaggagtct
actcgcttctatgaccaactgaaccatcacatttttgaattggtttccagctcagatgcc
aatgagaggaaaggtggcatcttggccatagctagcctcataggagtggaaggtgggaat
gccacccgaattggcagatttgccaactatcttcggaacctcctcccctccaatgaccca
gttgtcatggaaatggcatccaaggccattggccgtcttgccatggcaggggacactttt
accgctgagtacgtggaatttgaggtgaagcgagccctggaatggctgggtgctgaccgc
aatgagggccggagacatgcagctgtcctggttctccgtgagctggccatcagcgtccct
accttcttcttccagcaagtgcaacccttctttgacaacatttttgtggccgtgtgggac
cccaaacaggccatccgtgagggagctgtagccgcccttcgtgcctgtctgattctcaca
acccagcgtgagccgaaggagatgcagaagcctcagtggtacaggcacacatttgaagaa
gcagagaagggatttgatgagaccttggccaaagagaagggcatgaatcgggatgatcgg
atccatggagccttgttgatccttaacgagctggtccgaatcagcagcatggagggagag
cgtctgagagaagaaatggaagaaatcacacagcagcagctggtacacgacaagtactgc
aaagatctcatgggcttcggaacaaaacctcgtcacattacccccttcaccagtttccag
gctgtacagccccagcagtcaaatgccttggtggggctgctggggtacagctctcaccaa
ggcctcatgggatttgggacctcccccagtccagctaagtccaccctggtggagagccgg
tgttgcagagacttgatggaggagaaatttgatcaggtgtgccagtgggtgctgaaatgc
aggaatagcaagaactcgctgatccaaatgacaatccttaatttgttgccccgcttggct
gcattccgaccttctgccttcacagatacccagtatctccaagataccatgaaccatgtc
ctaagctgtgtcaagaaggagaaggaacgtacagcggccttccaagccctggggctactt
tctgtggctgtgaggtctgagtttaaggtctatttgcctcgcgtgctggacatcatccga
gcggccctgcccccaaaggacttcgcccataagaggcagaaggcaatgcaggtggatgcc
acagtcttcacttgcatcagcatgctggctcgagcaatggggccaggcatccagcaggat
atcaaggagctgctggagcccatgctggcagtgggactaagccctgccctcactgcagtg
ctctacgacctgagccgtcagattccacagctaaagaaggacattcaagatgggctactg
aaaatgctgtccctggtccttatgcacaaaccccttcgccacccaggcatgcccaagggc
ctggcccatcagctggcctctcctggcctcacgaccctccctgaggccagcgatgtgggc
agcatcactcttgccctccgaacgcttggcagctttgaatttgaaggccactctctgacc
caatttgttcgccactgtgcggatcatttcctgaacagtgagcacaaggagatccgcatg
gaggctgcccgcacctgctcccgcctgctcacaccctccatccacctcatcagtggccat
gctcatgtggttagccagaccgcagtgcaagtggtggcagatgtgcttagcaaactgctc
gtagttgggataacagatcctgaccctgacattcgctactgtgtcttggcgtccctggac
gagcgctttgatgcacacctggcccaggcggagaacttgcaggccttgtttgtggctctg
aatgaccaggtgtttgagatccgggagctggccatctgcactgtgggccgactcagtagc
atgaaccctgcctttgtcatgcctttcctgcgcaagatgctcatccagattttgacagag
ttggagcacagtgggattggaagaatcaaagagcagagtgcccgcatgctggggcacctg
gtctccaatgccccccgactcatccgcccctacatggagcctattctgaaggcattaatt
ttgaaactgaaagatccagaccctgatccaaacccaggtgtgatcaataatgtcctggca
acaataggagaattggcacaggttagtggcctggaaatgaggaaatgggttgatgaactt
tttattatcatcatggacatgctccaggattcctctttgttggccaaaaggcaggtggct
ctgtggaccctgggacagttggtggccagcactggctatgtagtagagccctacaggaag
taccctactttgcttgaggtgctactgaattttctgaagactgagcagaaccagggtaca
cgcagagaggccatccgtgtgttagggcttttaggggctttggatccttacaagcacaaa
gtgaacattggcatgatagaccagtcccgggatgcctctgctgtcagcctgtcagaatcc
aagtcaagtcaggattcctctgactatagcactagtgaaatgctggtcaacatgggaaac
ttgcctctggatgagttctacccagctgtgtccatggtggccctgatgcggatcttccga
gaccagtcactctctcatcatcacaccatggttgtccaggccatcaccttcatcttcaag
tccctgggactcaaatgtgtgcagttcctgccccaggtcatgcccacgttccttaacgtc
attcgagtctgtgatggggccatccgggaatttttgttccagcagctgggaatgttggtg
tcctttgtgaagagccacatcagaccttatatggatgaaatagtcaccctcatgagagaa
ttctgggtcatgaacacctcaattcagagcacgatcattcttctcattgagcaaattgtg
gtagctcttgggggtgaatttaagctctacctgccccagctgatcccacacatgctgcgt
gtcttcatgcatgacaacagcccaggccgcattgtctctatcaagttactggctgcaatc
cagctgtttggcgccaacctggatgactacctgcatttactgctgcctcctattgttaag
ttgtttgatgcccctgaagctccactgccatctcgaaaggcagcgctagagactgtggac
cgcctgacggagtccctggatttcactgactatgcctcccggatcattcaccctattgtt
cgaacactggaccagagcccagaactgcgctccacagccatggacacgctgtcttcactt
gtttttcagctggggaagaagtaccaaattttcattccaatggtgaataaagttctggtg
cgacaccgaatcaatcatcagcgctatgatgtgctcatctgcagaattgtcaagggatac
acacttgctgatgaagaggaggatcctttgatttaccagcatcggatgcttaggagtggc
caaggggatgcattggctagtggaccagtggaaacaggacccatgaagaaactgcacgtc
agcaccatcaacctccaaaaggcctggggcgctgccaggagggtctccaaagatgactgg
ctggaatggctgagacggctgagcctggagctgctgaaggactcatcatcgccctccctg
cgctcctgctgggccctggcacaggcctacaacccgatggccagggatctcttcaatgct
gcatttgtgtcctgctggtctgaactgaatgaagatcaacaggatgagctcatcagaagc
atcgagttggccctcacctcacaagacatcgctgaagtcacacagaccctcttaaacttg
gctgaattcatggaacacagtgacaagggccccctgccactgagagatgacaatggcatt
gttctgctgggtgagagagctgccaagtgccgagcatatgccaaagcactacactacaaa
gaactggagttccagaaaggccccacccctgccattctagaatctctcatcagcattaat
aataagctacagcagccggaggcagcggccggagtgttagaatatgccatgaaacacttt
ggagagctggagatccaggctacctggtatgagaaactgcacgagtgggaggatgccctt
gtggcctatgacaagaaaatggacaccaacaaggacgacccagagctgatgctgggccgc
atgcgctgcctcgaggccttgggggaatggggtcaactccaccagcagtgctgtgaaaag
tggaccctggttaatgatgagacccaagccaagatggcccggatggctgctgcagctgca
tggggtttaggtcagtgggacagcatggaagaatacacctgtatgatccctcgggacacc
catgatggggcattttatagagctgtgctggcactgcatcaggacctcttctccttggca
caacagtgcattgacaaggccagggacctgctggatgctgaattaactgcgatggcagga
gagagttacagtcgggcatatggggccatggtttcttgccacatgctgtccgagctggag
gaggttatccagtacaaacttgtccccgagcgacgagagatcatccgccagatctggtgg
gagagactgcagggctgccagcgtatcgtagaggactggcagaaaatccttatggtgcgg
tcccttgtggtcagccctcatgaagacatgagaacctggctcaagtatgcaagcctgtgc
ggcaagagtggcaggctggctcttgctcataaaactttagtgttgctcctgggagttgat
ccgtctcggcaacttgaccatcctctgccaacagttcaccctcaggtgacctatgcctac
atgaaaaacatgtggaagagtgcccgcaagatcgatgccttccagcacatgcagcatttt
gtccagaccatgcagcaacaggcccagcatgccatcgctactgaggaccagcagcataag
caggaactgcacaagctcatggcccgatgcttcctgaaacttggagagtggcagctgaat
ctacagggcatcaatgagagcacaatccccaaagtgctgcagtactacagcgccgccaca
gagcacgaccgcagctggtacaaggcctggcatgcgtgggcagtgatgaacttcgaagct
gtgctacactacaaacatcagaaccaagcccgcgatgagaagaagaaactgcgtcatgcc
agcggggccaacatcaccaacgccaccactgccgccaccacggccgccactgccaccacc
actgccagcaccgagggcagcaacagtgagagcgaggccgagagcaccgagaacagcccc
accccatcgccgctgcagaagaaggtcactgaggatctgtccaaaaccctcctgatgtac
acggtgcctgccgtccagggcttcttccgttccatctccttgtcacgaggcaacaacctc
caggatacactcagagttctcaccttatggtttgattatggtcactggccagatgtcaat
gaggccttagtggagggggtgaaagccatccagattgatacctggctacaggttatacct
cagctcattgcaagaattgatacgcccagacccttggtgggacgtctcattcaccagctt
ctcacagacattggtcggtaccacccccaggccctcatctacccactgacagtggcttct
aagtctaccacgacagcccggcacaatgcagccaacaagattctgaagaacatgtgtgag
cacagcaacaccctggtccagcaggccatgatggtgagcgaggagctgatccgagtggcc
atcctctggcatgagatgtggcatgaaggcctggaagaggcatctcgtttgtactttggg
gaaaggaacgtgaaaggcatgtttgaggtgctggagcccttgcatgctatgatggaacgg
ggcccccagactctgaaggaaacatcctttaatcaggcctatggtcgagatttaatggag
gcccaagagtggtgcaggaagtacatgaaatcagggaatgtcaaggacctcacccaagcc
tgggacctctattatcatgtgttccgacgaatctcaaagcagctgcctcagctcacatcc
ttagagctgcaatatgtttccccaaaacttctgatgtgccgggaccttgaattggctgtg
ccaggaacatatgaccccaaccagccaatcattcgcattcagtccatagcaccgtctttg
caagtcatcacatccaagcagaggccccggaaattgacacttatgggcagcaacggacat
gagtttgttttccttctaaaaggccatgaagatctgcgccaggatgagcgtgtgatgcag
ctcttcggcctggttaacacccttctggccaatgacccaacatctcttcggaaaaacctc
agcatccagagatacgctgtcatccctttatcgaccaactcgggcctcattggctgggtt
ccccactgtgacacactgcacgccctcatccgggactacagggagaagaagaagatcctt
ctcaacatcgagcatcgcatcatgttgcggatggctccggactatgaccacttgactctg
atgcagaaggtggaggtgtttgagcatgccgtcaataatacagctggggacgacctggcc
aagctgctgtggctgaaaagccccagctccgaggtgtggtttgaccgaagaaccaattat
acccgttctttagcggtcatgtcaatggttgggtatattttaggcctgggagatagacac
ccatccaacctgatgctggaccgtctgagtgggaagatcctgcacattgactttggggac
tgctttgaggttgctatgacccgagagaagtttccagagaagattccatttagactaaca
agaatgttgaccaatgctatggaggttacaggcctggatggcaactacagaatcacatgc
cacacagtgatggaggtgctgcgagagcacaaggacagtgtcatggccgtgctggaagcc
tttgtctatgaccccttgctgaactggaggctgatggacacaaataccaaaggcaacaag
cgatcccgaacgaggacggattcctactctgctggccagtcagtcgaaattttggacggt
gtggaacttggagagccagcccataagaaaacggggaccacagtgccagaatctattcat
tctttcattggagacggtttggtgaaaccagaggccctaaataagaaagctatccagatt
attaacagggttcgagataagctcactggtcgggacttctctcatgatgacactttggat
gttccaacgcaagttgagctgctcatcaaacaagcgacatcccatgaaaacctctgccag
tgctatattggctggtgccctttctggtaa

KEGG   Homo sapiens (human): 57521
Entry
57521             CDS       T01001                                 
Symbol
RPTOR, KOG1, Mip1
Name
(RefSeq) regulatory associated protein of MTOR complex 1
  KO
K07204  regulatory associated protein of mTOR
Organism
hsa  Homo sapiens (human)
Pathway
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04714  Thermogenesis
hsa04910  Insulin signaling pathway
hsa05131  Shigellosis
hsa05206  MicroRNAs in cancer
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    57521 (RPTOR)
   04152 AMPK signaling pathway
    57521 (RPTOR)
   04150 mTOR signaling pathway
    57521 (RPTOR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    57521 (RPTOR)
   04136 Autophagy - other
    57521 (RPTOR)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    57521 (RPTOR)
  09149 Aging
   04211 Longevity regulating pathway
    57521 (RPTOR)
   04213 Longevity regulating pathway - multiple species
    57521 (RPTOR)
  09159 Environmental adaptation
   04714 Thermogenesis
    57521 (RPTOR)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    57521 (RPTOR)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    57521 (RPTOR)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    57521 (RPTOR)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    57521 (RPTOR)
SSDB
Motif
Pfam: Raptor_N HEAT WD40 HEAT_2 Cnd1 ANAPC4_WD40 PDS5 WD40_2
Other DBs
NCBI-GeneID: 57521
NCBI-ProteinID: NP_065812
OMIM: 607130
HGNC: 30287
Ensembl: ENSG00000141564
UniProt: Q8N122 Q6DKI0
Structure
LinkDB
Position
17:80544838..80966368
AA seq 1335 aa
MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV
ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK
QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY
DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC
IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG
RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY
NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL
TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL
QSSARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILA
VIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSA
HEKLYSLLSDPIPEVRCAAVFALGTFVGNSAERTDHSTTIDHNVAMMLAQLVSDGSPMVR
KELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLRSV
SSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHILS
FETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYK
ATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVSRD
LPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTGFC
DWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIFLN
RNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQD
CSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMS
SGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALS
ECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALD
IHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGS
NDYYISVYSVEKRVR
NT seq 4008 nt   +upstreamnt  +downstreamnt
atggagtccgaaatgctgcaatcgcctcttctgggcctgggggaggaagatgaggctgat
cttacagactggaacctacctttggcttttatgaaaaagaggcactgtgagaaaattgaa
ggctccaaatccttagctcagagctggaggatgaaggatcggatgaagacagtcagtgtt
gccttagttttgtgcctgaatgttggtgtggaccctcccgatgtggtgaagaccacgccc
tgtgcacgcttggaatgctggatcgatcctctgtcgatgggtcctcagaaagctctggaa
accatcggtgcaaatttacagaagcagtacgagaactggcagccaagggcccggtacaag
cagagccttgacccaactgtggatgaagtcaagaagctctgcacgtccttacgtcgcaac
gccaaggaggagcgagtcctctttcactacaatggccacggggtgccccggcccacagtc
aacggggaggtctgggtcttcaacaagaactacacgcagtacatccctctgtccatatat
gacctgcagacgtggatgggcagcccgtcgatcttcgtctacgactgctccaatgctggc
ttgatcgtcaagtccttcaagcagttcgcactacagcgggagcaggagctggaggtagct
gcaatcaacccaaatcaccctcttgctcagatgcctttgcctccgtcgatgaaaaactgc
atccagctggcagcctgcgaggccaccgagctgctgcccatgatccccgacctcccggct
gacctattcacctcctgcctcaccacccccatcaagatcgccctgcgctggttttgcatg
cagaaatgtgtcagtctggtgcctggcgtcacactggatttgatagaaaagatccctggc
cgcctgaacgacaggaggacgcccctgggtgaactgaactggatcttcacagccatcaca
gacaccatcgcgtggaacgtgctcccccgggatctcttccaaaagctcttcagacaggac
ttgctggtggctagtctgtttcgaaattttttattggcggaaaggattatgaggtcgtat
aactgcactcccgtcagcagcccgcgtctgccgcccacgtacatgcacgccatgtggcaa
gcctgggacctggctgttgacatctgtctgtctcagctgccgacgatcatcgaggaaggc
actgcgtttcggcacagcccgttcttcgccgagcagctgaccgcattccaggtgtggctc
accatgggcgtggagaaccgaaacccacccgaacagctgcccatcgtcctgcaggtgctg
ttaagccaagtgcaccggctgagagcattggacttgcttggaagatttttggacctgggt
ccctgggcagtgagcctggccttgtctgtcggcatcttcccctacgtgctgaagctgctc
cagagctcggcccgagagctgcggccacttctcgttttcatctgggccaagatcctcgca
gtggacagctcgtgccaagcggacctcgtgaaggacaacggccacaagtacttcctgtcg
gtcctggcggacccctacatgccagctgaacaccggaccatgacggctttcattctcgcc
gtgatcgtcaacagctatcacacggggcaggaagcctgccttcagggaaacctcattgcc
atctgcctggagcagctcaacgacccgcaccccttgctgcgccagtgggtggccatctgc
ctcggcaggatctggcagaacttcgactcggcgaggtggtgcggcgtgagggacagcgct
catgagaagctctacagcctcctctccgaccccattcccgaggtccgctgcgcagcggtc
ttcgcccttggcacgttcgtgggcaactctgcagagaggacggaccactccaccaccatc
gaccacaacgtggccatgatgctggcccagctggtcagcgacgggagccccatggtccgg
aaggagctggtggtggctctgagtcatcttgtggttcagtatgaaagcaatttctgcacc
gtggccctgcagttcatagaagaggaaaagaactacgccttgccttctccagcaaccaca
gagggagggagtttgaccccagtgcgagacagcccgtgcacccccagacttcgttctgtg
agctcctatggaaacatccgtgctgtcgccacagccaggagcctcaacaaatctttgcag
aacctgagtttgacagaggaatctggtggcgcggtggcgttctcccccggaaacctcagc
accagcagcagcgccagcagcaccctgggcagccccgagaatgaggagcatatcctgtcc
ttcgagaccatcgacaagatgcgccgcgccagctcctactcctccctcaactccctcatc
ggagtttcctttaacagtgtttacactcagatttggagagtcctgctgcacctggctgct
gacccctatccagaggtctcggacgtggccatgaaagtactcaacagcatcgcctacaag
gccaccgtgaacgcccggccgcagcgcgtcctggacacctcctccctcacgcagtcggcc
cccgccagccccaccaacaagggcgtgcacatccaccaggcggggggctcccctccggcg
tccagcaccagcagctccagcctgaccaacgatgtggccaagcagccggtcagccgagac
ttgccttctggccggccgggcaccacaggccccgctggggcgcagtacacccctcactcc
caccagttcccccggacacggaagatgttcgacaagggcccagagcagactgcggacgac
gcggacgatgctgctggacacaaaagtttcatctccgccacggtgcagacggggttctgc
gactggagcgcccgctattttgcccagcccgtcatgaagatcccagaagagcacgacctg
gagagtcagatccgcaaggagcgggagtggcggttcctgcgaaacagccgtgtcaggagg
caggcccagcaagtcattcagaagggcattacgagattggacgaccaaatatttctgaac
aggaaccccggcgtcccctctgtggtgaaattccaccccttcacgccgtgcatcgccgta
gccgacaaggacagcatctgcttttgggactgggagaaaggggagaagctggattatttc
cacaatgggaaccctcggtacacgagggtcactgccatggagtatctgaacggccaggac
tgctcgcttctgctgacggccacagacgatggtgccatcagggtctggaagaattttgct
gatttggaaaagaacccagagatggtgaccgcgtggcaggggctctcggacatgctgcca
acgacgcgaggagctgggatggtggtggactgggagcaggagaccggcctcctcatgagc
tcaggagacgtgcggatcgtccggatctgggacacagaccgtgagatgaaggtgcaggac
atccctacgggcgcagacagctgtgtgacgagtctgtcctgtgattcccaccgctcactc
atcgtggctggcctcggtgacggctccatccgcgtctacgacagaaggatggcactcagc
gaatgccgcgtcatgacgtaccgggagcacacagcctgggtggtgaaggcctccctgcag
aagcgtcccgacggccacatcgtgagtgtgagcgtcaatggagatgtgcgcatctttgat
ccccggatgcctgagtcggtaaatgtgcttcagatcgtgaaggggctgacggccctggac
atccacccccaggcggacctgatcgcatgtggctccgtcaatcagttcaccgccatctac
aacagcagcggagagctcatcaacaacatcaagtactacgacggcttcatgggccagcgg
gtcggcgccatcagctgcctggccttccacccgcactggcctcacctggccgtgggaagc
aacgactactacatctccgtgtactcggtggagaagcgtgtcagatag

KEGG   Homo sapiens (human): 84335
Entry
84335             CDS       T01001                                 
Symbol
AKT1S1, Lobe, PRAS40
Name
(RefSeq) AKT1 substrate 1
  KO
K16184  proline-rich AKT1 substrate 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04714  Thermogenesis
hsa05131  Shigellosis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    84335 (AKT1S1)
   04150 mTOR signaling pathway
    84335 (AKT1S1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    84335 (AKT1S1)
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    84335 (AKT1S1)
   04213 Longevity regulating pathway - multiple species
    84335 (AKT1S1)
  09159 Environmental adaptation
   04714 Thermogenesis
    84335 (AKT1S1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    84335 (AKT1S1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    84335 (AKT1S1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    84335 (AKT1S1)
SSDB
Motif
Pfam: PRAS PRAS_NT Senescence_reg
Other DBs
NCBI-GeneID: 84335
NCBI-ProteinID: NP_001092102
OMIM: 610221
HGNC: 28426
Ensembl: ENSG00000204673
UniProt: Q96B36
Structure
LinkDB
Position
19:complement(49869033..49878356)
AA seq 256 aa
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARR
CLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQL
GISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQY
AKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLP
RPRLNTSDFQKLKRKY
NT seq 771 nt   +upstreamnt  +downstreamnt
atggcgtcggggcgccccgaggagctgtgggaggccgtggtgggggccgctgagcgcttc
cgggcccggactggcacggagctggtgctgctgaccgcggccccgccgccaccaccccgc
ccgggcccctgtgcctatgctgcccatggtcgaggagccctggcggaggcagcgcgccgt
tgcctccacgacatcgcactggcccacagggctgccactgctgctcggcctcctgcgccc
ccaccagcaccacagccacccagtcccacacccagcccaccccggcctaccctggccaga
gaggacaacgaggaggacgaggatgagcccacagagacagagacctccggggagcagctg
ggcattagtgataatggagggctctttgtgatggatgaggacgccaccctccaggacctt
ccccccttctgtgagtcagaccccgagagtacagatgatggcagcctgagcgaggagacc
cccgccggcccccccacctgctcagtgcccccagcctcagccctacccacacagcagtac
gccaagtccctgcctgtgtctgtgcccgtctggggcttcaaggagaagaggacagaggcg
cggtcatcagatgaggagaatgggccgccctcttcgcccgacctggaccgcatcgcggcg
agcatgcgcgcgctggtgctgcgagaggccgaggacacccaggtcttcggggacctgcca
cggccgcggcttaacaccagcgacttccagaagctgaagcggaaatattga

KEGG   Homo sapiens (human): 64798
Entry
64798             CDS       T01001                                 
Symbol
DEPTOR, DEP.6, DEPDC6, hDEPTOR
Name
(RefSeq) DEP domain containing MTOR interacting protein
  KO
K20402  DEP domain-containing mTOR-interacting protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    64798 (DEPTOR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    64798 (DEPTOR)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    64798 (DEPTOR)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    64798 (DEPTOR)
   mTORC2 complex
    64798 (DEPTOR)
SSDB
Motif
Pfam: DEP PDZ_6 GPAT_C PDZ
Other DBs
NCBI-GeneID: 64798
NCBI-ProteinID: NP_073620
OMIM: 612974
HGNC: 22953
Ensembl: ENSG00000155792
UniProt: Q8TB45
Structure
LinkDB
Position
8:119873722..120050918
AA seq 409 aa
MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY
PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD
DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
NT seq 1230 nt   +upstreamnt  +downstreamnt
atggaggagggcggcagcactggcagtgctggcagtgacagcagcaccagcgggagtggc
ggggcgcagcaaagggagctggagcgcatggctgaggtcttggtcaccggggaacagcta
cggctcaggctgcacgaagaaaaggttattaaagatagacgtcatcatctcaagacctac
ccaaactgttttgtcgcaaaagaactgattgactggctgattgaacacaaagaggcttct
gacagagagacggcaattaaactcatgcagaaattagcagaccggggcattattcaccat
gtgtgtgatgagcataaggaattcaaggatgtcaaactcttctaccgctttagaaaggat
gacggcaccttcccattggataatgaagtgaaggcctttatgagaggacagaggctatat
gaaaagctgatgagccctgaaaacacactcctgcagcccagggaggaggaaggggtcaag
tatgagcgcaccttcatggcatctgaattcctggactggctggttcaggaaggtgaggcc
accacgaggaaagaggcagagcagctttgccaccggcttatggagcatggcatcatccag
catgtgtccaacaagcacccatttgtggacagcaatcttctctaccagttcagaatgaac
ttccggcggaggcgaagactgatggagctgctcaatgaaaagtccccctcctcccaggaa
actcatgacagtcccttctgcctgaggaagcagagccatgacaatcggaaatctaccagc
tttatgtcagtgagccccagcaaggagatcaagatcgtgtctgcagtgaggagaagcagc
atgagcagctgtggcagcagcggctacttcagcagcagccccaccctcagcagcagcccc
cctgtgctctgcaaccccaagtccgtgctgaagagacctgtcacctctgaggaactcctt
actcccggggctccgtatgcaaggaagacattcacgattgttggtgacgcggttggctgg
ggttttgtggtgcgaggaagtaagccatgccacatccaggctgtagaccccagtggccct
gcagccgcagcaggaatgaaggtctgtcagtttgtcgtctctgtcaacgggctcaatgtc
ctgcatgtagactaccggaccgtgagcaatctgattctgacgggcccacggacgattgtc
atggaagtcatggaggagttagagtgctga

KEGG   Homo sapiens (human): 64223
Entry
64223             CDS       T01001                                 
Symbol
MLST8, GBL, GbetaL, LST8, POP3, WAT1
Name
(RefSeq) MTOR associated protein, LST8 homolog
  KO
K08266  target of rapamycin complex subunit LST8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04714  Thermogenesis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    64223 (MLST8)
   04150 mTOR signaling pathway
    64223 (MLST8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    64223 (MLST8)
   04136 Autophagy - other
    64223 (MLST8)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    64223 (MLST8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    64223 (MLST8)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    64223 (MLST8)
   mTORC2 complex
    64223 (MLST8)
SSDB
Motif
Pfam: WD40 ANAPC4_WD40 TAF1C_beta-prop Hira DUF5854
Other DBs
NCBI-GeneID: 64223
NCBI-ProteinID: NP_001186102
OMIM: 612190
HGNC: 24825
Ensembl: ENSG00000167965
UniProt: Q9BVC4
Structure
LinkDB
Position
16:2205454..2209453
AA seq 326 aa
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
NT seq 981 nt   +upstreamnt  +downstreamnt
atgaacacctccccaggcacggtgggcagtgacccggtcatcctggccactgcaggctac
gaccacaccgtgcgcttctggcaggcccacagcggcatctgcacccggacggtgcagcac
caggactcccaggtgaatgccttggaggtcacaccggaccgcagcatgattgctgctgca
ggttaccagcacatccgcatgtatgatctcaactccaataaccctaaccccatcatcagc
tacgacggcgtcaacaagaacatcgcgtctgtgggcttccacgaagacggccgctggatg
tacacgggcggcgaggactgcacagccaggatctgggacctcaggtcccggaacctgcag
tgccagcggatcttccaggtgaacgcacccattaactgcgtgtgcctgcaccccaaccag
gcagagctcatcgtgggtgaccagagcggggctatccacatctgggacttgaaaacagac
cacaacgagcagctgatccctgagcccgaggtctccatcacgtccgcccacatcgatccc
gacgccagctacatggcagctgtcaatagcaccggaaactgctatgtctggaatctgacg
gggggcattggtgacgaggtgacccagctcatccccaagactaagatccctgcccacacg
cgctacgccctgcagtgtcgcttcagccccgactccacgctcctcgccacctgctcggct
gatcagacgtgcaagatctggaggacgtccaacttctccctgatgacggagctgagcatc
aagagcggcaaccccggggagtcctcccgcggctggatgtggggctgcgccttctcgggg
gactcccagtacatcgtcactgcttcctcggacaacctggcccggctctggtgtgtggag
actggagagatcaagagagagtatggcggccaccagaaggctgttgtctgcctggccttc
aatgacagtgtgctgggctag

KEGG   Homo sapiens (human): 9894
Entry
9894              CDS       T01001                                 
Symbol
TELO2, CLK2, TEL2, YHFS
Name
(RefSeq) telomere maintenance 2
  KO
K11137  telomere length regulation protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa03460  Fanconi anemia pathway
hsa04150  mTOR signaling pathway
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Disease
H01789  You-Hoover-Fong syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    9894 (TELO2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    9894 (TELO2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    9894 (TELO2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    9894 (TELO2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    9894 (TELO2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    9894 (TELO2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromatin remodeling factors
   ASTRA complex
    9894 (TELO2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   FA (Fanconi anemia) pathway
    Other FA pathway factors
     9894 (TELO2)
  Check point factors
   Triple T complex
    9894 (TELO2)
SSDB
Motif
Pfam: Telomere_reg-2
Other DBs
NCBI-GeneID: 9894
NCBI-ProteinID: NP_057195
OMIM: 611140
HGNC: 29099
Ensembl: ENSG00000100726
UniProt: Q9Y4R8 B4DXS2
Structure
LinkDB
Position
16:1493360..1510454
AA seq 837 aa
MEPAPSEVRLAVREAIHALSSSEDGGHIFCTLESLKRYLGEMEPPALPREKEEFASAHFS
PVLRCLASRLSPAWLELLPHGRLEELWASFFLEGPADQAFLVLMETIEGAAGPSFRLMKM
ARLLARFLREGRLAVLMEAQCRQQTQPGFILLRETLLGKVVALPDHLGNRLQQENLAEFF
PQNYFRLLGEEVVRVLQAVVDSLQGGLDSSVSFVSQVLGKACVHGRQQEILGVLVPRLAA
LTQGSYLHQRVCWRLVEQVPDRAMEAVLTGLVEAALGPEVLSRLLGNLVVKNKKAQFVMT
QKLLFLQSRLTTPMLQSLLGHLAMDSQRRPLLLQVLKELLETWGSSSAIRHTPLPQQRHV
SKAVLICLAQLGEPELRDSRDELLASMMAGVKCRLDSSLPPVRRLGMIVAEVVSARIHPE
GPPLKFQYEEDELSLELLALASPQPAGDGASEAGTSLVPATAEPPAETPAEIVDGGVPQA
QLAGSDSDLDSDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTSEDIERWEAALRALEG
LVYRSPTATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFY
ALNYSLRQRMDILDVLTLAAQELSRPGCLGRTPQPGSPSPNTPCLPEAAVSQPGSAVASD
WRVVVEERIRSKTQRLSKGGPRQGPAGSPSRFNSVAGHFFFPLLQRFDRPLVTFDLLGED
QLVLGRLAHTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLS
LPAARLLEDLMDELLEARSWLADVAEKDPDEDCRTLALRALLLLQRLKNRLLPPASP
NT seq 2514 nt   +upstreamnt  +downstreamnt
atggagccagcaccctcagaggttcgactcgccgtccgggaagccattcatgccctctcg
tcttcggaggatggcggccacatcttctgcaccctggagtccctgaagcggtatctcggt
gagatggagcctccagcgctcccgagggagaaggaggagtttgcctcggcccacttctcg
cctgtcctcagatgtcttgccagcaggctgagcccagcctggctggagctgctgccccat
ggccgcctggaggagctgtgggccagcttcttcctggagggcccggcggaccaagccttc
ctggtgttgatggagaccatcgagggtgctgcgggccccagcttccggctgatgaagatg
gcgcggctgctggccagattcctgcgcgagggccggctggcagtgctgatggaggcgcag
tgtcggcagcagacgcagcccggcttcatcctgctccgggagacgctgctgggcaaggtg
gtggccctgcccgatcacctgggcaaccgcctgcagcaggagaacttggccgagttcttc
ccccagaactacttccgcctgctcggcgaggaggtcgtccgggtgctgcaggcggttgtg
gactctctccaaggtggcctggattcctccgtgtccttcgtgtctcaggtccttgggaaa
gcctgtgtccacgggaggcagcaggagatcctgggcgtgctggtaccccggctggcagcg
ctcacccagggcagctacctgcaccagcgcgtctgctggcgcctggtggagcaagtgccg
gaccgggccatggaggctgtgctgaccgggctggtggaggccgcactggggcctgaggtc
ctttcgagactgctggggaacctggtggtgaagaacaagaaggcccagtttgtgatgacc
cagaagcttctgttcttacagtcccggctcacgacgcccatgctgcagagcctgctgggc
catctggccatggacagccagcggcgcccgctcctgctgcaggtgctgaaggagctgttg
gagacgtggggcagcagcagtgccatccgccacactcccctgccgcagcagcgccacgtc
agcaaggctgtcctcatctgcctggcgcaactcggggagccggaactgcgggacagccgg
gatgaactgctggccagcatgatggcgggcgtgaagtgccgcctggacagtagcctgccc
cccgtgcgacgcctgggcatgatcgtggcagaggtcgttagtgcccggatccaccccgag
gggcctcccctgaaattccagtacgaagaggatgaactgagcctcgagctgctggccttg
gcctccccccagcctgcgggtgacggcgcctcggaggcgggcacgtccctcgttccagcc
acggcagagccccctgcagagacccccgcagagatcgtggatggcggcgtcccccaagca
cagctggcgggctctgactcggacctggacagcgatgatgagtttgtcccctacgacatg
tcgggggacagagagctgaagagcagcaaggctcctgcctacgtccgggactgcgtggaa
gccctgaccacgtctgaggacatagagcgctgggaggcagccctgcgggcccttgagggc
ctggtctacaggagccccacagccactcgggaggtgagcgtggagctggccaaggtgctt
ctgcatctggaggagaagacctgtgtggtgggatttgcagggctgcgccagagagccctg
gtggccgtcacggtcacagacccggccccggtggccgactatctgacctcacagttctat
gccctcaactacagcctccggcagcgcatggacatcctggatgtgctgactctggctgcc
caggagctgtctaggcctgggtgcctcgggaggactccccaacctggctccccaagtccc
aacaccccgtgcctgccagaggcagccgtctctcagcctggcagtgccgtggcgtctgac
tggcgggtggtggtggaggagcggatcagaagcaagacccagcggctctccaagggtggc
ccgaggcagggcccggcaggcagccccagcagattcaactccgtggccggccacttcttc
ttccccctccttcagcgctttgacaggcctctggtgaccttcgacctcttgggagaagac
cagctggttctcggaaggctggcgcacaccttaggggccctgatgtgcctggctgttaac
accacggtggctgtggccatgggcaaggccctgctggaattcgtgtgggcccttcgcttc
cacatcgatgcctacgtgcgccaggggctgttgtcggccgtctcctccgtcctgctcagc
ctgcctgctgcgcgcctgctggaggacctgatggacgagctgctggaagcccggtcctgg
ctggcggacgtggctgagaaagacccggacgaggactgcaggacgctggcactgagggcc
ctgctgcttctgcagagactcaagaacaggctcctcccacccgcgtctccctag

KEGG   Homo sapiens (human): 9675
Entry
9675              CDS       T01001                                 
Symbol
TTI1, KIAA0406, NEDMIM, smg-10
Name
(RefSeq) TELO2 interacting protein 1
  KO
K20403  TELO2-interacting protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Disease
H02461  Neurodevelopmental disorder with microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    9675 (TTI1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9675 (TTI1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    9675 (TTI1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromatin remodeling factors
   ASTRA complex
    9675 (TTI1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Check point factors
   Triple T complex
    9675 (TTI1)
SSDB
Motif
Pfam: TTI1 DUF5331 Dopey_N VHS Cnd1 DUF5503 EFR3_ARM
Other DBs
NCBI-GeneID: 9675
NCBI-ProteinID: NP_001290386
OMIM: 614425
HGNC: 29029
Ensembl: ENSG00000101407
UniProt: O43156
Structure
LinkDB
Position
20:complement(37983021..38033456)
AA seq 1089 aa
MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTRLQAVSDSALQELQQYILFPLRFTL
KTPGPKRERLIQSVVECLTFVLSSTCVKEQELLQELFSELSACLYSPSSQKPAAVSEELK
LAVIQGLSTLMHSAYGDIILTFYEPSILPRLGFAVSLLLGLAEQEKSKQIKIAALKCLQV
LLLQCDCQDHPRSLDELEQKQLGDLFASFLPGISTALTRLITGDFKQGHSIVVSSLKIFY
KTVSFIMADEQLKRISKVQAKPAVEHRVAELMVYREADWVKKTGDKLTILIKKIIECVSV
HPHWKVRLELVELVEDLLLKCSQSLVECAGPLLKALVGLVNDESPEIQAQCNKVLRHFAD
QKVVVGNKALADILSESLHSLATSLPRLMNSQDDQGKFSTLSLLLGYLKLLGPKINFVLN
SVAHLQRLSKALIQVLELDVADIKIVEERRWNSDDLNASPKTSATQPWNRIQRRYFRFFT
DERIFMLLRQVCQLLGYYGNLYLLVDHFMELYHQSVVYRKQAAMILNELVTGAAGLEVED
LHEKHIKTNPEELREIVTSILEEYTSQENWYLVTCLETEEMGEELMMEHPGLQAITSGEH
TCQVTSFLAFSKPSPTICSMNSNIWQICIQLEGIGQFAYALGKDFCLLLMSALYPVLEKA
GDQTLLISQVATSTMMDVCRACGYDSLQHLINQNSDYLVNGISLNLRHLALHPHTPKVLE
VMLRNSDANLLPLVADVVQDVLATLDQFYDKRAASFVSVLHALMAALAQWFPDTGNLGHL
QEQSLGEEGSHLNQRPAALEKSTTTAEDIEQFLLNYLKEKDVADGNVSDFDNEEEEQSVP
PKVDENDTRPDVEPPLPLQIQIAMDVMERCIHLLSDKNLQIRLKVLDVLDLCVVVLQSHK
NQLLPLAHQAWPSLVHRLTRDAPLAVLRAFKVLRTLGSKCGDFLRSRFCKDVLPKLAGSL
VTQAPISARAGPVYSHTLAFKLQLAVLQGLGPLCERLDLGEGDLNKVADACLIYLSVKQP
VKLQEAARSVFLHLMKVDPDSTWFLLNELYCPVQFTPPHPSLHPVQLHGASGQQNPYTTN
VLQLLKELQ
NT seq 3270 nt   +upstreamnt  +downstreamnt
atggcagtttttgatactcctgaggaggcctttggtgtcttacgtccagtctgtgttcag
ctcacaaagacccagacagtggagaatgtggagcatctgcagacacgactacaagctgtg
agtgacagtgcccttcaggaacttcagcagtacatcctcttccctctgcgatttaccctg
aagaccccaggtcccaaaagagagcgtttgatccaaagtgtggtggaatgcctcacattt
gtcctttcttcaacatgtgtgaaagaacaggagcttctccaggaactcttttcagaactc
tctgcttgtctgtattcacccagctcccaaaaacctgcggctgtgtccgaggagttgaaa
ttggctgtgatccagggacttagcacattaatgcactcagcttatggggacatcattctg
actttttatgagccctccattctgccacgtttaggatttgctgtatctttactgttaggc
cttgcagaacaggagaaatcaaagcaaattaaaattgctgccttaaaatgtttacaggtt
ctactcttgcagtgtgattgtcaggaccatccaaggtcattggatgaacttgaacaaaag
cagctgggggatttgtttgcctcttttttacctggaatctcaactgcactgaccaggctt
atcacaggagactttaaacaaggtcacagcattgtcgtatcttccctaaagatcttttac
aagacagtgagcttcattatggctgatgaacagctcaaaagaatctcaaaggtccaagca
aaacctgcagttgagcacagagtagcagagctgatggtttacagggaagcagattgggta
aaaaagactggcgacaagttgactatccttattaaaaagataattgagtgtgtttctgtt
cacccacactggaaggtgagactggaactggtagaacttgtggaggaccttcttttgaag
tgcagtcaatcattggtcgaatgtgctggtccccttctgaaggccttagtgggactagta
aatgatgagagtcctgaaatccaagcccagtgcaataaagttctgagacattttgcagat
caaaaagtagtggtgggcaacaaagccctcgctgacatcttgtcagaaagcctgcattcc
cttgccacatctcttcctcgcctaatgaactcccaagatgaccagggcaaattctctact
ctttccttgttacttggttatctgaaactcttgggcccaaaaataaactttgtcctcaac
tctgtggcccatctccagcggctttccaaagcactcatccaagttctagagctagacgtg
gctgacatcaagattgttgaggaacggcgttggaactctgatgatctgaatgcttctcca
aagacctcagccacacagccttggaaccgcatccagaggagatatttccgcttcttcact
gatgagagaatcttcatgctcttgaggcaggtttgtcagctacttggttattatgggaat
ctttatttgcttgtggatcactttatggaactttaccatcaatctgtggtttaccggaag
caagctgccatgatccttaatgaactggttacaggggctgctgggctggaggttgaggat
cttcacgaaaaacatattaaaacaaacccagaagaactgagagagattgtgacatctata
cttgaagaatacacaagtcaagaaaattggtatttggttacctgtcttgaaactgaggaa
atgggagaggagctgatgatggagcacccaggcctccaagccatcacgtctggtgaacac
acctgccaagttacatcttttctagccttctcaaagccaagtcccactatttgctccatg
aacagtaacatctggcaaatatgcattcagttggaaggaattggccagtttgcatatgca
ctaggaaaagacttctgtttgctcttgatgtcagccctttatccagtactggagaaggct
ggagaccaaaccctactcattagtcaggtggctaccagcaccatgatggacgtttgccgt
gcttgtggctacgactccctgcagcacctgatcaatcaaaattcagactatttagtgaat
gggatctctttaaatctgcgtcatctggctctgcatcctcataccccaaaggtcctggaa
gtcatgctgcggaactcagatgctaacctgcttcctttggtggcagatgtggttcaagat
gtcttggccaccctggaccaattttacgataagagagctgcttcctttgtcagcgttctg
catgctctgatggcagcattagcccagtggttcccagacacaggtaatcttgggcacctc
caagagcaaagtttaggagaagagggaagtcatttgaaccaaagaccagcagctcttgag
aagagcaccaccacagctgaagacatcgaacagtttttgctgaactacctcaaagagaag
gatgtggcagatggaaatgtctcggattttgataatgaagaagaggaacagtcagtccct
cccaaagtggatgagaatgacacccgtccagatgtggagccaccactgccattgcagatc
caaatagccatggacgtgatggaacgctgcatccacttgttgtcagataaaaatctgcaa
atccgcctgaaggtcttggatgtgctggatctgtgtgtggttgttcttcagtcccacaaa
aaccagctgcttcccttggctcatcaggcctggccctcgctcgttcaccgactcacacgg
gacgcccccctggcagtgcttagagccttcaaggttttacgtaccctgggaagcaagtgt
ggtgactttcttcgcagccggttctgcaaagatgtcctgccaaagctggctggctcccta
gtcacccaggcccccatcagtgccagggctggaccagtttactcgcacacgctggccttc
aagttgcagctggctgtcttacagggcctgggccccctctgtgagagactggacctaggt
gagggtgacctgaataaagtggctgatgcctgcttgatttacctcagtgtcaaacagccc
gtgaaattacaagaggctgccaggagcgtcttcctccacttgatgaaggtggacccagac
tccacctggttcctcctgaacgagctttactgccccgtgcagttcacacctccccacccc
agcctccaccctgtgcagctgcacggggccagcgggcagcagaacccctacacgaccaac
gtgctccagctgctcaaggagctgcagtga

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