KEGG   PATHWAY: char04010
Entry
char04010                   Pathway                                
Name
MAPK signaling pathway - Clupea harengus (Atlantic herring)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
char04010  MAPK signaling pathway
char04010

Other DBs
GO: 0000165
Organism
Clupea harengus (Atlantic herring) [GN:char]
Gene
105900243  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
105892182  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105889899  cacna1ba; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
105912627  cacna1bb; probable voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105911367  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105898925  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105903391  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
105898242  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105891294  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
105898895  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
105893627  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
105903286  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105899901  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
105892183  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105908852  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
105897327  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
105900081  cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
105889635  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
105910328  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
105895841  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
105903398  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
105898928  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
105903388  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
122132928  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
105891511  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
105911364  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
105890760  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122129424  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
105897273  cacnb3b; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
105912747  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
122131761  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
105889629  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
105898521  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105900228  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
105891649  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
105908858  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105899937  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105905766  voltage-dependent calcium channel gamma-2 subunit [KO:K04868]
105898700  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
105900214  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105891854  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105900215  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a isoform X1 [KO:K04870]
105902062  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
105894975  cacng6b; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
105902015  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
105894702  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X2 [KO:K04872]
105901978  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
105894622  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
105899109  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X3 [KO:K04345] [EC:2.7.11.11]
122130206  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
105910964  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
105891269  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105900227  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
105892049  prkcab; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
105899995  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105905767  prkcba; LOW QUALITY PROTEIN: protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
105894611  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105890330  guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105890719  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
116218708  gng14; GGL domain-containing protein [KO:K04347]
105895117  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105897431  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105893045  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105889776  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
105890035  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X3 [KO:K04348] [EC:3.1.3.16]
105895419  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
122132202  calcineurin subunit B type 1 isoform X1 [KO:K06268]
105901568  ppp3r1b; calcineurin subunit B type 1b isoform X1 [KO:K06268]
105905553  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105901165  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
105911801  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
105897135  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
105909226  RAS guanyl-releasing protein 1 [KO:K04350]
105895414  RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
105895053  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
105911596  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
105908693  rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018]
105903569  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
122128541  rapgef2b; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
122129257  LOW QUALITY PROTEIN: neurofibromin-like [KO:K08052]
105902812  nf1a; neurofibromin isoform X1 [KO:K08052]
105890530  nf1b; neurofibromin [KO:K08052]
105901256  rasa1a; ras GTPase-activating protein 1 [KO:K04352]
105890812  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
105902821  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
105901888  ras-related protein Rap-1A-like [KO:K04353]
105902222  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
105892499  ras-related protein Rap-1b [KO:K07836]
105906165  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105889175  LOW QUALITY PROTEIN: protransforming growth factor alpha [KO:K08774]
122132925  tgfa; protransforming growth factor alpha [KO:K08774]
105909155  fibroblast growth factor 1 isoform X3 [KO:K18496]
105902783  putative fibroblast growth factor 1 [KO:K18496]
105901770  fgf2; fibroblast growth factor 2 [KO:K18497]
105896755  fibroblast growth factor 6 [KO:K04358]
105889011  fgf7; fibroblast growth factor 7 [KO:K04358]
105901081  fgf17; fibroblast growth factor 17 [KO:K04358]
105905971  fibroblast growth factor 18-like [KO:K04358]
105911269  fgf3; fibroblast growth factor 3 [KO:K04358]
105911284  fgf4; fibroblast growth factor 4 [KO:K04358]
105911577  fgf8a; fibroblast growth factor 8 [KO:K04358]
105902888  fgf10b; fibroblast growth factor 10b [KO:K04358]
105902982  fgf16; fibroblast growth factor 16 [KO:K04358]
105912649  fgf20b; fibroblast growth factor 20b [KO:K04358]
105891026  fgf8b; fibroblast growth factor 8b [KO:K04358]
105893086  fgf18a; fibroblast growth factor 18a [KO:K04358]
105908953  fgf10a; fibroblast growth factor 10a [KO:K04358]
105893693  fgf24; fibroblast growth factor 24 [KO:K04358]
105895040  fgf22; fibroblast growth factor 22 [KO:K04358]
105906880  fgf5; fibroblast growth factor 5 [KO:K04358]
105907021  fgf20a; fibroblast growth factor 20a [KO:K04358]
105895682  fgf6a; fibroblast growth factor 6a [KO:K04358]
105889059  fgf19; fibroblast growth factor 19 isoform X1 [KO:K22603]
105897666  fgf21; fibroblast growth factor 21 isoform X1 [KO:K22429]
105896677  fgf23; fibroblast growth factor 23 [KO:K22428]
105906386  ngfa; neurotrophin-7 [KO:K02582]
105909845  ngfb; nerve growth factor [KO:K02582]
105893071  bdnf; brain-derived neurotrophic factor isoform X3 [KO:K04355]
105898360  ntf3; neurotrophin-3 [KO:K04356]
105898511  insulin [KO:K04526]
105902849  insb; preproinsulin b [KO:K04526]
105901030  ins; insulin [KO:K04526]
105902602  igf1; insulin-like growth factor I isoform X2 [KO:K05459]
105908126  insulin-like growth factor II [KO:K13769]
105904486  igf2b; insulin-like growth factor 2b isoform X2 [KO:K13769]
105897421  platelet-derived growth factor subunit A-like [KO:K04359]
105905811  platelet-derived growth factor subunit A-like [KO:K04359]
122133303  uncharacterized protein LOC122133303 [KO:K04359]
105903833  si:ch211-79m20.1; LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 1.1 [KO:K17386]
105909300  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
105906158  pdgfc; platelet-derived growth factor C [KO:K05450]
105910307  kitlga; kit ligand a isoform X1 [KO:K05461]
122132029  kitlgb; kit ligand b isoform X1 [KO:K05461]
105897631  vegfaa; vascular endothelial growth factor A-A isoform X3 [KO:K05448]
105899546  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
116223738  snake venom vascular endothelial growth factor toxin ICPP-like [KO:K16859]
105908459  vegfc; vascular endothelial growth factor C isoform X2 [KO:K05449]
105904591  vascular endothelial growth factor C-like [KO:K05449]
105893271  vegfd; vascular endothelial growth factor D [KO:K05449]
105910388  hepatocyte growth factor [KO:K05460]
105904094  hgfa; hepatocyte growth factor a [KO:K05460]
105909009  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
122131827  angiopoietin-1-like [KO:K05465]
105910567  angiopoietin-1-like [KO:K05465]
105911611  angpt2a; angiopoietin-2a [KO:K05466]
105889547  angpt2b; LOW QUALITY PROTEIN: angiopoietin-2b [KO:K05466]
105896419  ephrin-A2 [KO:K05462]
105901438  efna3a; ephrin-A3 isoform X1 [KO:K05462]
105901464  efna1a; ephrin-A1a [KO:K05462]
105890846  efna5a; ephrin-A5 isoform X1 [KO:K05462]
105891802  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
105891858  efna3b; ephrin-A3b [KO:K05462]
105891860  efna1b; ephrin-A1b [KO:K05462]
105908532  efna2a; ephrin-A2 isoform X1 [KO:K05462]
105901116  glial cell line-derived neurotrophic factor [KO:K05452]
105911812  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
105900927  nrtn; neurturin [KO:K25414]
116218461  glial cell line-derived neurotrophic factor [KO:K25414]
105895034  neurturin isoform X1 [KO:K25415]
105905784  persephin [KO:K25416]
105896901  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105900501  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105902239  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122128993  erbb2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105897265  erbb3b; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
105909946  erbb3a; receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
105896610  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
105907911  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105902754  fgfr1a; fibroblast growth factor receptor 1-A isoform X2 [KO:K04362] [EC:2.7.10.1]
105912648  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
105890944  fgfr2; fibroblast growth factor receptor 2 isoform X5 [KO:K05093] [EC:2.7.10.1]
105909593  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105893699  fgfr4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105899258  nradd; death domain-containing membrane protein NRADD [KO:K02583]
105898538  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105909070  ngfrb; nerve growth factor receptor b [KO:K02583]
105891941  ntrk1; high affinity nerve growth factor receptor isoform X4 [KO:K03176] [EC:2.7.10.1]
105894377  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
105902823  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
105900980  insrb; insulin receptor b isoform X2 [KO:K04527] [EC:2.7.10.1]
105889494  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
105904485  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
105893090  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105895070  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116220866  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105904594  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
105904593  csf1rb; macrophage colony-stimulating factor 1 receptor 1 [KO:K05090] [EC:2.7.10.1]
122130699  macrophage colony-stimulating factor 1 receptor-like [KO:K05090] [EC:2.7.10.1]
105908497  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
105895097  kita; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
122131722  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105913074  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
105890153  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
105906254  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105895252  kdr; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105895653  met; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105902491  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
105898935  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105909956  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
105890844  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105901960  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
105892101  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
105901955  growth factor receptor-bound protein 2-like [KO:K04364]
105890999  sos2; son of sevenless homolog 2 [KO:K03099]
105905794  son of sevenless homolog 1 isoform X1 [KO:K03099]
105908806  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
105892655  GTPase HRas-like [KO:K02833]
105897575  GTPase KRas [KO:K07827]
105900436  kras; GTPase KRas isoform X1 [KO:K07827]
105894964  zgc:55558 [KO:K07827]
105889759  nras; GTPase NRas [KO:K07828]
105898756  rras; ras-related protein R-Ras [KO:K07830]
105906557  rras2; ras-related protein R-Ras2 [KO:K07830]
105905680  mrasb; ras-related protein M-Ras [KO:K07831]
105890001  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105912424  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105904961  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105900156  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X2 [KO:K04366] [EC:2.7.11.1]
105892387  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116219257  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
122132003  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
105905870  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116219516  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105905067  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
105889999  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116218829  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
105910285  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105900880  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
105895212  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
105908348  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X3 [KO:K04373] [EC:2.7.11.1]
105905216  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
105904577  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
105911642  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105906315  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105890801  atf4b; activating transcription factor 4b [KO:K04374]
105893548  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105899078  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105895870  elk4; ETS domain-containing protein Elk-4 isoform X2 [KO:K04376]
105889299  myca; transcriptional regulator Myc-A [KO:K04377]
105907531  mycb; transcriptional regulator Myc-B [KO:K04377]
122131877  serum response factor-like isoform X1 [KO:K04378]
105891549  srfa; serum response factor a [KO:K04378]
105889778  si:ch211-153j24.3; proto-oncogene c-Fos [KO:K04379]
105889814  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
105893125  fosaa; proto-oncogene c-Fos isoform X1 [KO:K04379]
105910042  stmn1b; stathmin 1b [KO:K04381]
105903712  stathmin-like [KO:K04381]
105910777  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116218983  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
122129428  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
122131250  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105910565  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
105890870  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
105890871  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105910569  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105910564  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105904695  tumor necrosis factor-like [KO:K03156]
116225080  tumor necrosis factor-like [KO:K03156]
105904955  interleukin-1 beta-like isoform X1 [KO:K04519]
116222824  interleukin-1 beta-like [KO:K04519]
105904765  interleukin-1 beta-like [KO:K04519]
116222930  interleukin-1 beta-like isoform X1 [KO:K04519]
105890611  transforming growth factor beta-1 proprotein-like [KO:K13375]
105904460  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
105911025  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
105905499  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
105909434  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
122132153  transforming growth factor beta-3 proprotein-like [KO:K13377]
105896149  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105909647  interleukin-1 receptor type 1 [KO:K04386]
105909637  zmp:0000000936; interleukin-1 receptor-like 2 [KO:K04386]
105909293  interleukin-1 receptor accessory protein [KO:K04723]
105900515  tgfbr1a; TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
105890151  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
105908942  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105903669  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
105907906  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122131951  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105900818  fas; uncharacterized protein fas [KO:K04390]
122130089  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
122130579  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
105892187  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105899959  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
105891207  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105895933  cdc42; LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
105901650  cdc42l; cell division cycle 42, like [KO:K04393]
105892051  cell division control protein 42 homolog [KO:K04393]
105906845  cell division control protein 42 homolog [KO:K04393]
105891104  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105894697  caspase-3-like [KO:K02187] [EC:3.4.22.56]
105892611  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
105891672  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
105902465  TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
105891184  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122130680  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
105890158  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105899000  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105908798  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105913349  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
105889045  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105896452  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105913263  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 isoform X2 [KO:K04402]
105904319  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
105906135  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
105895248  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
105893549  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
105897093  tab2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105904885  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
105893436  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105905793  mitogen-activated protein kinase kinase kinase kinase 3-like isoform X1 [KO:K04406] [EC:2.7.11.1]
105893325  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
105907831  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105898321  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
105906139  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
105901859  serine/threonine-protein kinase 4-like [KO:K04411]
105907728  stk3; serine/threonine-protein kinase 3 [KO:K04412]
105896254  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
105903108  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
105897242  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
105894653  map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
105903099  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
105898540  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
105890180  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
105908153  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
105903203  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105888571  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X2 [KO:K17534] [EC:2.7.11.25]
105900012  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
105912646  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105901603  mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
122130830  mitogen-activated protein kinase kinase kinase 20-like isoform X1 [KO:K04424] [EC:2.7.11.25]
105897682  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105899459  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105894847  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105890949  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
105896252  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105909111  taok2b; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
105898214  taok1a; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
105911994  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
105893877  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
122130773  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
122130801  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
105904987  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105893604  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105894965  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
105902976  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
105895585  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
105912027  mapk8ip2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
105890690  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
105890626  flna; filamin-A isoform X1 [KO:K04437]
105889293  crkl; crk-like protein [KO:K04438]
105906601  adapter molecule crk-like [KO:K04438]
105907844  crk; adapter molecule crk isoform X1 [KO:K04438]
105904870  arrestin red cell isoform X1 [KO:K04439]
105902401  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
105890606  arrb1; beta-arrestin-1 [KO:K04439]
105893927  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105912369  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
105911485  mapk10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
105904364  mapk8a; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
105907444  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105893670  mapk14a; mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
105898139  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
105911368  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105889751  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
105889772  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105905144  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105895558  mapkapk5; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
116220526  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105904174  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105906811  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
122130789  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
105898012  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105906596  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
105899671  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
105891992  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105905363  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105908735  nfatc3b; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105899768  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105891385  transcription factor AP-1 [KO:K04448]
122131950  jun; transcription factor AP-1 [KO:K04448]
105902506  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
105906981  jund; transcription factor jun-D [KO:K04449]
105908058  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X3 [KO:K04450]
105907172  cellular tumor antigen p53 [KO:K04451]
105906573  cellular tumor antigen p53-like [KO:K04451]
105906613  cellular tumor antigen p53-like isoform X1 [KO:K04451]
105912172  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105889819  max; protein max isoform X1 [KO:K04453]
105909807  protein max isoform X1 [KO:K04453]
105901221  mef2cb; myocyte enhancer factor 2cb isoform X3 [KO:K04454]
105890176  mef2ca; myocyte enhancer factor 2ca isoform X2 [KO:K04454]
105896093  hspb1; heat shock protein beta-1 [KO:K04455]
105911019  heat shock protein beta-1-like [KO:K04455]
105892226  heat shock protein beta-1-like [KO:K04455]
105908327  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105899505  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105895803  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105912451  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105907254  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
105897783  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab isoform X1 [KO:K04457] [EC:3.1.3.16]
105909458  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
105899712  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
105904464  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
105912374  ptprr; receptor-type tyrosine-protein phosphatase R isoform X2 [KO:K04458] [EC:3.1.3.48]
105906457  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105906318  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105909157  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105909616  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105900175  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105902706  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105904771  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105893512  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105905802  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105906555  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105899395  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105899940  dusp3b; dual specificity protein phosphatase 3b [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105888725  dusp3a; dual specificity protein phosphatase 3 isoform X2 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105890608  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
105912462  ppm1ba; protein phosphatase 1B isoform X3 [KO:K04461] [EC:3.1.3.16]
105904124  ppm1bb; protein phosphatase 1bb isoform X2 [KO:K04461] [EC:3.1.3.16]
105896343  heat shock 70 kDa protein-like [KO:K03283]
105903789  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
105900363  heat shock cognate 70 kDa protein [KO:K03283]
105900380  heat shock cognate 70 kDa protein-like [KO:K03283]
105897347  hspa1b; LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
105906367  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
116219755  heat shock 70 kDa protein-like [KO:K03283]
105905815  heat shock 70 kDa protein [KO:K03283]
105899625  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
105906492  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
105892715  mapk7; mitogen-activated protein kinase 7 isoform X2 [KO:K04464] [EC:2.7.11.24]
105897944  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
105898527  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105903749  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105902233  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
105898455  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105894130  ikbkg; NF-kappa-B essential modulator isoform X3 [KO:K07210]
105902814  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
105911998  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
105912617  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
105900314  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
105903142  rela; transcription factor p65 [KO:K04735]
105907824  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Docking interactions in the mitogen-activated protein kinase cascades.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
char04070  Phosphatidylinositol signaling system
char04110  Cell cycle
char04115  p53 signaling pathway
char04210  Apoptosis
char04310  Wnt signaling pathway
KO pathway
ko04010   
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