KEGG   ORTHOLOGY: K04437
Entry
K04437                      KO                                     

Name
FLNA
Definition
filamin
Pathway
ko04010  MAPK signaling pathway
ko04510  Focal adhesion
ko05132  Salmonella infection
ko05205  Proteoglycans in cancer
Disease
H00270  Periventricular nodular heterotopia
H00456  Fronto-otopalatodigital syndromes
H00499  Spondylocarpotarsal synostosis syndrome
H00594  Distal myopathy
H00595  Myofibrillar myopathies
H00894  FG syndrome
H01276  Chronic idiopathic intestinal pseudo-obstruction
H01740  Macrothrombocytopenia
H02048  Larsen syndrome
H02064  Atelosteogenesis type I and III
H02067  Boomerang dysplasia
H02227  Frontometaphyseal dysplasia
H02229  Terminal osseous dysplasia
H02230  X-linked cardiac valvular dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04437  FLNA; filamin
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04437  FLNA; filamin
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K04437  FLNA; filamin
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04437  FLNA; filamin
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K04437  FLNA; filamin
   04147 Exosome
    K04437  FLNA; filamin
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     K04437  FLNA; filamin
  Intermediate filaments
   Intermediate filament-binding proteins
    K04437  FLNA; filamin
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04437  FLNA; filamin
Genes
HSA: 2316(FLNA) 2317(FLNB) 2318(FLNC)
PTR: 460476(FLNB) 463711(FLNC) 465940(FLNA)
PPS: 100980320(FLNA) 100991254(FLNC) 100992733(FLNB)
GGO: 101130344(FLNB) 101134853(FLNA) 101142657(FLNC)
PON: 100436976(FLNB) 100446579(FLNA) 100447210(FLNC)
NLE: 100584689(FLNC) 100597513(FLNA) 100603369(FLNB)
MCC: 699524(FLNA) 700223(FLNC) 702732(FLNB)
MCF: 102114837(FLNC) 102134285(FLNB) 102138509(FLNA)
CSAB: 103226867(FLNC) 103227804(FLNB) 103232822(FLNA)
RRO: 104660189(FLNB) 104663540(FLNA) 104674436(FLNC)
RBB: 108518765 108518766(FLNA) 108543601(FLNB) 108544858(FLNC)
CJC: 100385221(FLNA) 100394911(FLNB) 100397531(FLNC)
SBQ: 101030782(FLNC) 101033199(FLNB) 101038946(FLNA)
MMU: 192176(Flna) 286940(Flnb) 68794(Flnc)
MCAL: 110287345(Flna) 110297122(Flnc) 110308932(Flnb)
MPAH: 110314123(Flna) 110316290(Flnc) 110325251(Flnb)
RNO: 293860(Flna) 306204(Flnb) 362332(Flnc)
MUN: 110554614(Flnb) 110562530(Flna) 110564415(Flnc)
CGE: 100751994(Flnc) 100760050(Flna) 100769967(Flnb)
NGI: 103726600 103731216(Flna) 103740547(Flnb) 103744557(Flnc) 103752279
HGL: 101702004(Flna) 101714131(Flnb) 101714775(Flnc)
CCAN: 109679690 109684086(Flnc) 109696859(Flna)
OCU: 100008760(FLNB) 100328754(FLNA) 100328756(RA_M006_JSM7BED4F) 100353671(FLNC)
TUP: 102493536(FLNA) 102497970(FLNB) 102498440(FLNC)
CFA: 481084(FLNA) 482266(FLNC) 484713(FLNB)
VVP: 112909750(FLNB) 112911473(FLNA) 112928910(FLNC)
AML: 100467791(FLNA) 100475857(FLNC) 100481308(FLNB)
UMR: 103674200(FLNB) 103676641(FLNC) 103679686(FLNA)
UAH: 113247826(FLNA) 113257012(FLNB) 113263925(FLNC)
ORO: 101380560(FLNA) 101382948(FLNB) 101383660(FLNC)
ELK: 111144333 111151946
FCA: 101081210(FLNC) 101082637(FLNA) 101098612(FLNB)
PTG: 102951673(FLNB) 102958609(FLNC) 102969406(FLNA)
PPAD: 109259850(FLNA) 109268963(FLNC) 109279138(FLNB)
AJU: 106968844(FLNB) 106973900(FLNC) 106989714(FLNA)
BTA: 281165(FLNA) 528415(FLNC) 613533(FLNB)
BOM: 102265714(FLNB) 102281567(FLNA) 102287936(FLNC)
BIU: 109555118(FLNA) 109557606(FLNC) 109576011(FLNB)
BBUB: 102398881(FLNC) 102403050(FLNA) 102411216(FLNB)
CHX: 102170485(FLNC) 102176601(FLNA) 102187630(FLNB)
OAS: 101104655(FLNC) 101120390(FLNA) 101123330(FLNB)
SSC: 100514491(FLNB) 100518997(FLNC) 733585(FLNA)
CFR: 102514709(FLNA) 102515088(FLNB) 102522311(FLNC)
CDK: 105085371(FLNC) 105089800(FLNB) 105098720(FLNA)
BACU: 103000025(FLNA) 103001285(FLNC) 103018177(FLNB)
LVE: 103070633(FLNA) 103082555(FLNB) 103085481(FLNC)
OOR: 101275748(FLNA) 101277589(FLNC) 101285072(FLNB)
DLE: 111170584(FLNA) 111174250(FLNB) 111178654(FLNC)
PCAD: 102987028(FLNB) 102988864(FLNA) 102994181(FLNC)
ECB: 100057963(FLNB) 100058256(FLNA) 100071760(FLNC)
EPZ: 103544267 103544977 103550598(FLNB)
EAI: 106825616(FLNA) 106839532(FLNC) 106848649(FLNB)
MYB: 102246018(FLNC) 102255293(FLNB) 102257802(FLNA)
MYD: 102756703(FLNC) 102761579(FLNB) 102764268(FLNA)
MNA: 107531471(FLNB) 107537382(FLNC) 107545550(FLNA)
HAI: 109377338(FLNA) 109384635(FLNC) 109388247(FLNB)
DRO: 112296269(FLNA) 112299880(FLNC) 112301177(FLNB)
PALE: 102887099(FLNB) 102889996(FLNA) 102894137(FLNC)
RAY: 107499467(FLNA) 107503384(FLNB) 107512795(FLNC)
MJV: 108387997(FLNA) 108392169(FLNC) 108394917(FLNB)
LAV: 100655159(FLNB) 100666153(FLNC) 100674763(FLNA)
TMU: 101344096 101344651 101361822
MDO: 100014156(FLNB) 100014995(FLNC) 100617907(FLNA)
SHR: 100923582(FLNB) 100924343(FLNA) 100932639(FLNC)
PCW: 110195967(FLNB) 110200343(FLNA) 110219227(FLNC)
OAA: 100077046(FLNA) 100078338(FLNC) 100084462(FLNB)
GGA: 378913(FLNB) 395260(FLNC) 395261(FLNA)
MGP: 100549125(FLNB)
CJO: 107307149 107319866
NMEL: 110404616(FLNB)
APLA: 101796074(FLNB)
ACYG: 106037975(FLNB) 106048920(FLNC)
TGU: 100224625(FLNC) 100230709(FLNB)
LSR: 110471636(FLNB) 110479584(FLNC) 110482785
SCAN: 103817009(FLNB) 103822494(FLNC)
GFR: 102038057(FLNB) 102039906(FLNC)
FAB: 101807613(FLNC) 101815478(FLNB)
PHI: 102102293(FLNA) 102109930(FLNC) 102113738(FLNB)
PMAJ: 107198769(FLNC) 107210334(FLNB)
CCAE: 111923226 111935101(FLNB)
CCW: 104683467(FLNB)
ETL: 114057964(FLNB) 114071946 114072022
FPG: 101914782(FLNB) 101921248(FLNC)
FCH: 102048385(FLNC) 102055640(FLNB)
CLV: 102090285 102090492(FLNB)
EGZ: 104126644(FLNB)
NNI: 104015311 104019559 104022661(FLNB)
ACUN: 113484731(FLNB)
PADL: 103915476(FLNB)
AAM: 106497553 106497558 106498419
ASN: 102367807(FLNC) 102368306(FLNB) 102370975(FLNA)
AMJ: 102570042(FLNB) 102572603(FLNC) 102573539(FLNA)
PSS: 102454001(FLNB)
CMY: 102942474(FLNC) 102947590(FLNB)
CPIC: 101935574(FLNA) 101948714(FLNC) 101953493(FLNB)
ACS: 100555896(flnc) 100557416(flnb) 100559302 100562207(flna)
PVT: 110078614(FLNA) 110082409(FLNB) 110089402(FLNC)
PBI: 103050411(FLNC) 103063627(FLNA) 103064197(FLNB)
PMUR: 107286711(FLNA) 107287783(FLNB) 107298381
TSR: 106549701 106555396
PMUA: 114587359(FLNA) 114591708(FLNB) 114606020(FLNC)
GJA: 107110009 107116981(FLNC) 107124864 107124877
XLA: 108699999 108704467 108705104(flnb.L) 108705610 108715054 108715939 733321 734178(flnc.L)
XTR: 100329116(flnc) 100485165(flnb) 779840(flna)
NPR: 108790450(FLNA) 108791862(FLNB) 108794883(FLNC)
DRE: 100048921(flnca) 100534866(flnb) 562529(flna) 563023(flnb) 570288(flncb)
SRX: 107712729 107712990 107728418 107737611 107737717 107740233 107743297 107744996 107747421(flnb)
SANH: 107656281 107657976 107658721 107667687 107671935 107671980 107680511 107695945 107699576
SGH: 107555727 107557390 107560077 107560870 107560941 107570276 107580954 107592205 107597200
CCAR: 109048731 109048732 109048852 109050942 109062869 109063319 109063927 109066092 109095391
IPU: 101154674 108254750(flnb) 108269034 108279881
PHYP: 113525442 113530592 113532351 113537897(flnb)
AMEX: 103026913 103027821 103028247 103028460(flnb) 103033794
EEE: 113570037 113572410 113582685 113588770
TRU: 101067631 101073720 101076847 101077561
TNG: GSTEN00008691G001 GSTEN00011646G001 GSTEN00012499G001 GSTEN00029754G001
LCO: 104935653 104936022 104936893 104940629
NCC: 104941162 104950639 104952439 104958599 104963709(flnc)
MZE: 101465053 101468348 101474102(flnb) 101481790
ONL: 100698591 100702302 100703257 100710324(flnb) 100711120
OLA: 101165476(flnc) 101166705 101173301
XMA: 102222032(flnb) 102226553 102231807 102236849
XCO: 114136239(flnb) 114141752 114160393 114160779
PRET: 103459815(flnc) 103464344(flnb) 103466366 103466954
CVG: 107086022(flnc) 107097300 107098922 107100771
NFU: 107385073(flnb) 107387851(flnc) 107388592 107391531
KMR: 108230074 108244931(flnb) 108248408 108249180
ALIM: 106523011 106523651 106532586 106535645
AOCE: 111565150 111567354 111569203 111574650 111574658(flnc) 111585313 111586986
CSEM: 103380304 103382463 103384725 103386855
POV: 109624441 109630731 109645095 109646377 109646803
LCF: 108874767(flnb) 108882420 108888498 108899610
SDU: 111219449 111229481 111229537 111237012
SLAL: 111654847 111657325 111669172 111670874
HCQ: 109521545(flnb) 109522986 109528584 109532675
BPEC: 110157711(flnb) 110161376(flnc) 110167142 110169294
MALB: 109966400(flnb) 109969966 109974778 109974858
SASA: 100380643(flna) 106561692 106573040 106576205 106583816(flnb) 106609299
OTW: 112214278 112222449 112232341 112232475 112236628 112237703 112241106 112255105(flnb)
SALP: 111951555 111953025 112067846 112071583 112071999 112072697 112080586
ELS: 105013504 105013563(flnb) 105021804(flnc)
SFM: 108918413(flna) 108920915 108929804(flnb) 108931558 108939278
PKI: 111837459(flnb) 111842285 111844361 111847024 111856989
LCM: 102345455(FLNA) 102352444(FLNC) 102360310(FLNB)
CMK: 103190015(flnc) 103190036(flnb)
RTP: 109919721 109926218 109929423(flnb)
BFO: 118416663 118427524 118427565 118428053 118428054 118428056 118428139
CIN: 100186514 108950006
SPU: 579510 587438
APLC: 110981724 110984900
SKO: 100369791 100376702
DME: Dmel_CG30092(jbug) Dmel_CG3937(cher) Dmel_CG5984(CG5984)
DER: 6547363 6552233 6554687
DSE: 6616793
DSI: Dsimw501_GD15083(Dsim_GD15083) Dsimw501_GD20251(Dsim_GD20251) Dsimw501_GD25106(Dsim_GD25106)
DYA: Dyak_GE10575 Dyak_GE11838 Dyak_GE26108
DAN: 6494193 6500647
DSR: 110177384 110177670 110188210
DPO: Dpse_GA15644 Dpse_GA19276 Dpse_GA26775
DPE: 6591275 6598760
DMN: 108154422 108154867 108158563 117189861
DWI: 6640245 6647415 6649821
DGR: Dgri_GH14254 Dgri_GH16673 Dgri_GH22092 Dgri_GH22093
DMO: Dmoj_GI22300 Dmoj_GI23147
DAZ: 108616303 108620707 108620815
DNV: 108653691 108654561 108658987
DHE: 111594610 111597865 111604175
DVI: 6632599
MDE: 101889283 101893179 101894339
LCQ: 111680403 111684412 111689623
AGA: AgaP_AGAP004335 AgaP_AGAP007006
AAG: 5564736 5572167
AALB: 109400433 109415818 109425672 115253838
CQU: CpipJ_CPIJ001681 CpipJ_CPIJ001684 CpipJ_CPIJ006590 CpipJ_CPIJ006592
AME: 409697 410171
BIM: 100741876 100747901
BTER: 100645301 100648105
CCAL: 108626157 108628359
OBB: 114871630 114871673 114879492
SOC: 105200463 105204017
MPHA: 105831017 105831938
AEC: 105147512 105149573
ACEP: 105622372 105623131
PBAR: 105423174 105425908
VEM: 105562387 105568579
HST: 105180971 105182494
DQU: 106742642 106747268
CFO: 105247995 105249451
LHU: 105667827 105669548
PGC: 109852621 109857611
OBO: 105278695 105280206
PCF: 106785593 106787496
NVI: 100113977 100123445
CSOL: 105362158 105365188
MDL: 103569203 103574099
TCA: 660035 661488
DPA: 109537263 109540952
ATD: 109603301 109606679 109607464 109608800
NVL: 108562060 108567672 108567696
BMOR: 101738519 101739163 105841403
BMAN: 114239553 114247953
DPL: KGM_203067A KGM_203067B
PMAC: 106711223 106712396
PRAP: 110993869 111000535
HAW: 110370243 110375042
TNL: 113492703 113497913
PXY: 105384276 105385518
API: 100162552 100167253
DNX: 107161548 107168231 107171885
AGS: 114127245 114128507 114131999
RMD: 113555156 113556632
BTAB: 109037284 109038974
CLEC: 106661376
PHU: Phum_PHUM051600 Phum_PHUM051710 Phum_PHUM076810
ZNE: 110828237 110836878
FCD: 110851458 110856313
DPX: DAPPUDRAFT_208250 DAPPUDRAFT_328542 DAPPUDRAFT_328543
PVM: 113803313 113828411 113828414
ISC: IscW_ISCW006509 IscW_ISCW006929 IscW_ISCW022060
TUT: 107359464 107360506
DPTE: 113789953 113792656 113794675
CSCU: 111636054 111637673 111642528
PTEP: 107438849 107442083 107457153
CEL: CELE_C23F12.1(fln-2) CELE_Y66H1B.2(fln-1)
CBR: CBG10541 CBG10542 CBG16142(Cbr-flna-1)
BMY: Bm1_15795 Bm1_34190 Bm1_47900
LOA: LOAG_02284 LOAG_06970 LOAG_16538 LOAG_17559
NAI: NECAME_01517 NECAME_02591
TSP: Tsp_02523 Tsp_02524 Tsp_12104 Tsp_12751
HRO: HELRODRAFT_116537 HELRODRAFT_161920 HELRODRAFT_173407 HELRODRAFT_178024 HELRODRAFT_181576 HELRODRAFT_186524 HELRODRAFT_189327 HELRODRAFT_190944 HELRODRAFT_192560 HELRODRAFT_194084 HELRODRAFT_72745 HELRODRAFT_74935
LGI: LOTGIDRAFT_158607 LOTGIDRAFT_160005 LOTGIDRAFT_221912 LOTGIDRAFT_229996 LOTGIDRAFT_231195 LOTGIDRAFT_231196
PCAN: 112554279 112555457 112555568 112555763 112571578
CRG: 105325934 105327611 105327831 105348068
MYI: 110451856 110454123 110456708 110458033 110462500
OBI: 106873036 106873575 106873618 106879792 106882456 106884050
LAK: 106158579 106166693 106169918 106172234
SMM: Smp_000100 Smp_156590 Smp_198050
SHX: MS3_00852 MS3_01744
OVI: T265_01131 T265_02321
EGL: EGR_01619 EGR_04458
NVE: 5517292 5519085
EPA: 110234502 110234969 110240971
ADF: 107340122 107341369
AMIL: 114948457 114962179
PDAM: 113683703 113686251
SPIS: 111328433 111330767
DGT: 114530535 114530587 114530596 114531938 114543401
HMG: 100204838 100206373
TAD: TRIADDRAFT_62084
AQU: 100636841 100640166 100640228 100640490 100640617 105312304 105316875
CSL: COCSUDRAFT_83706
OTA: OT_ostta10g02060
MIS: MICPUN_59850
DDI: DDB_G0269100(abpC)
DPP: DICPUDRAFT_91322
DFA: DFA_01474(abpC)
EHI: EHI_104630(3.t00014)
EDI: EDI_145990
EIV: EIN_281230 EIN_416960 EIN_462230
ACAN: ACA1_133600 ACA1_173100 ACA1_304270
AAF: AURANDRAFT_66237
PIF: PITG_07307
PSOJ: PHYSODRAFT_555666
GTT: GUITHDRAFT_64440
NGR: NAEGRDRAFT_80016(AM3)
 » show all
Reference
  Authors
Adams M, Simms RJ, Abdelhamed Z, Dawe HR, Szymanska K, Logan CV, Wheway G, Pitt E, Gull K, Knowles MA, Blair E, Cross SH, Sayer JA, Johnson CA
  Title
A meckelin-filamin A interaction mediates ciliogenesis.
  Journal
Hum Mol Genet 21:1272-86 (2012)
DOI:10.1093/hmg/ddr557
  Sequence
[hsa:2316] [mmu:192176]
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