KEGG   PATHWAY: ko04514
Entry
ko04514                     Pathway                                

Name
Cell adhesion molecules
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ko04514  Cell adhesion molecules
ko04514

Disease
H00586  Epidermolysis bullosa, junctional
H00639  Ectodermal dysplasia, ectrodactyly, and macular dystrophy
H00742  Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome
H00756  Pitt-Hopkins syndrome
H00785  Congenital hypotrichosis with juvenile macular dystrophy
H00805  Vitreoretinal degeneration
H00840  Band-like calcification with simplified gyration and polymicrogyria
H01034  L1 syndrome
H01155  Roussy-Levy syndrome
H01210  Hypomagnesemia
H01490  Multiple sclerosis
H01677  Congenital hydrocephalus
H01882  Asperger syndrome
H02073  Wagner syndrome
H02111  Autism
H02178  MASA syndrome
Other DBs
GO: 0050839
Orthology
K06492  CD58 antigen
K06449  T-cell surface glycoprotein CD2
K23268  V-type immunoglobulin domain-containing suppressor of T-cell activation
K06791  immunoglobulin superfamily, member 11
K05412  CD80 antigen
K06745  programmed cell death 1 ligand 1
K06470  CD28 antigen
K05413  CD86 antigen
K06538  cytotoxic T-lymphocyte-associated protein 4
K06710  inducible T-cell co-stimulator ligand
K06713  inducible T-cell co-stimulator
K06752  MHC class II antigen
K10784  T cell receptor alpha chain V region
K10785  T-cell receptor beta chain V region
K06454  T-cell surface glycoprotein CD4
K06751  MHC class I antigen
K06458  T-cell surface glycoprotein CD8 alpha chain
K06459  T-cell surface glycoprotein CD8 beta chain
K06708  programmed cell death 1 ligand 2
K06746  immune costimulatory protein B7-H3
K06747  immune costimulatory protein B7-H4
K06744  programmed cell death protein 1
K03160  tumor necrosis factor receptor superfamily member 5
K03161  tumor necrosis factor ligand superfamily member 5
K06547  activated leukocyte cell adhesion molecule
K06456  T-cell surface glycoprotein CD6
K06539  poliovirus receptor
K06567  CD226 antigen
K06531  poliovirus receptor-related protein 2
K16350  T-cell immunoreceptor with Ig and ITIM domains
K05718  integrin alpha L
K06464  integrin beta 2
K06490  intercellular adhesion molecule 1
K06523  intercellular adhesion molecule 2
K06486  intercellular adhesion molecule 3
K06467  CD22 antigen
K06478  receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
K06548  sialoadhesin
K06477  sialophorin
K06592  poliovirus receptor-related protein 3
K06087  claudin
K06088  occludin
K06089  junctional adhesion molecule 1
K06735  junctional adhesion molecule 2
K06785  junctional adhesion molecule 3
K06787  endothelial cell adhesion molecule
K06533  cadherin 5, type 2, VE-cadherin
K06471  platelet/endothelial cell adhesion molecule
K06520  CD99 antigen
K06461  integrin alpha M
K06544  selectin P ligand
K06496  selectin, platelet
K06483  integrin alpha 4
K05719  integrin beta 1
K06585  integrin alpha 9
K06527  vascular cell adhesion molecule 1
K06590  integrin beta 7
K06779  mucosal vascular addressin cell adhesion molecule 1
K06495  selectin, lymphocyte
K06815  glycosylation dependent cell adhesion molecule 1
K06474  CD34 antigen
K06816  golgi apparatus protein 1
K06494  selectin, endothelial cell
K06081  poliovirus receptor-related protein 1
K06736  cadherin 2, type 1, N-cadherin
K06491  neural cell adhesion molecule
K06550  L1 cell adhesion molecule
K06781  cell adhesion molecule 1
K06775  neuronal growth regulator 1
K07522  netrin-G1
K07523  netrin-G1 ligand
K16359  netrin-G2
K16351  netrin-G2 ligand
K05695  receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48]
K16360  netrin-G3 ligand
K06257  syndecan 1
K16336  syndecan 2
K16337  syndecan 3
K16338  syndecan 4
K06487  integrin alpha V
K06591  integrin beta 8
K06584  integrin alpha 8
K07377  neurexin
K07378  neuroligin
K06780  cell adhesion molecule 3
K06756  neuronal cell adhesion molecule
K06759  contactin 1
K05693  receptor-type tyrosine-protein phosphatase mu [EC:3.1.3.48]
K06760  contactin 2
K06757  neurofascin
K07379  contactin associated protein 1
K07380  contactin associated protein-like 2
K06770  myelin protein zero
K06771  myelin associated glycoprotein
K05689  cadherin 1, type 1, E-cadherin
K06793  versican core protein
K06485  integrin alpha 6
K06796  cadherin 3, type 1, P-cadherin
K06797  cadherin 4, type 1, R-cadherin
K06809  cadherin 15, M-cadherin
K06766  neogenin
Reference
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
ko04520  Adherens junction
ko04530  Tight junction
ko04610  Complement and coagulation cascades
ko04660  T cell receptor signaling pathway
ko04670  Leukocyte transendothelial migration
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