KEGG   PATHWAY: aam04530
Entry
aam04530                    Pathway                                
Name
Tight junction - Apteryx mantelli mantelli (North Island brown kiwi)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
aam04530  Tight junction
aam04530

Other DBs
GO: 0005923
Organism
Apteryx mantelli mantelli (North Island brown kiwi) [GN:aam]
Gene
106490986  CLDN34; claudin 34 [KO:K06087]
106498560  CLDN2; claudin 2 [KO:K06087]
106498591  claudin-16-like [KO:K06087]
106497975  CLDN1; claudin 1 [KO:K06087]
106498099  CLDN16; claudin 16 [KO:K06087]
106484677  CLDN3; claudin 3 [KO:K06087]
106484678  CLDN4; claudin 4 [KO:K06087]
106484679  claudin-4-like [KO:K06087]
106486853  CLDN5; claudin 5 [KO:K06087]
106484739  claudin-15-like [KO:K06087]
106491673  CLDN10; claudin 10 [KO:K06087]
106484000  claudin-22-like [KO:K06087]
106486579  CLDN11; claudin 11 [KO:K06087]
106482265  CLDN18; claudin 18 [KO:K06087]
106484026  claudin-22-like [KO:K06087]
106485187  CLDN25; claudin 25 [KO:K06087]
106494927  CLDN14; claudin 14 [KO:K06087]
106494929  claudin-8-like [KO:K06087]
106494930  claudin-8-like [KO:K06087]
106497866  CLDN20; claudin 20 [KO:K06087]
106483614  CLDN12; claudin 12 [KO:K06087]
106496010  occludin-like [KO:K06088]
106500061  F11R; F11 receptor [KO:K06089]
106494882  JAM2; junctional adhesion molecule 2 [KO:K06735]
106490228  JAM3; junctional adhesion molecule 3 [KO:K06785]
106489704  BVES; blood vessel epicardial substance [KO:K21108]
106498596  CDC42; cell division cycle 42 [KO:K04393]
106486456  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
106500265  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
106489442  partitioning defective 6 homolog beta-like [KO:K06093]
106482794  MPP5; membrane palmitoylated protein 5 [KO:K06091]
106492467  MPP4; membrane palmitoylated protein 4 [KO:K21109]
106484847  TJP3; tight junction protein 3 [KO:K06097]
106490524  PATJ; PATJ, crumbs cell polarity complex component [KO:K06092]
106496073  MPDZ; multiple PDZ domain crumbs cell polarity complex component [KO:K06095]
106485752  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
106486590  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
106489313  AMOT; angiomotin [KO:K16819]
106495490  AMOTL1; angiomotin like 1 [KO:K06104]
106492622  AMOTL2; angiomotin like 2 [KO:K06104]
106486189  ARHGAP17; Rho GTPase activating protein 17 [KO:K20638]
106491345  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
106495350  merlin-like [KO:K16684]
106494533  NF2; neurofibromin 2 [KO:K16684]
106492930  LLGL1; LLGL1, scribble cell polarity complex component [KO:K06094]
106485666  LLGL2; LLGL2, scribble cell polarity complex component [KO:K06094]
106485876  DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
106482081  SCRIB; scribbled planar cell polarity protein [KO:K16175]
106487221  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
106494814  uncharacterized LOC106494814 [KO:K04382] [EC:3.1.3.16]
106487247  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
106498740  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
106489262  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
106494284  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
106489948  PARD3; par-3 family cell polarity regulator [KO:K04237]
106494979  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
106496461  TJP1; tight junction protein 1 [KO:K05701]
106485537  TJAP1; tight junction associated protein 1 [KO:K06105]
106484805  DLG2; discs large MAGUK scaffold protein 2 [KO:K12075]
106496522  E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
106487216  E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
106484827  CGN; cingulin [KO:K06102]
106496518  CGNL1; cingulin like 1 [KO:K21110]
106491145  RHOA; ras homolog family member A [KO:K04513]
106483921  GATA4; GATA binding protein 4 [KO:K09183]
106498803  MARVELD3; MARVEL domain containing 3 [KO:K21099]
106493358  MARVEL domain-containing protein 3-like [KO:K21099]
106482359  MARVEL domain-containing protein 3-like [KO:K21099]
106493457  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
106496655  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106497812  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106494500  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
106497235  antigen-presenting glycoprotein CD1d-like [KO:K06448]
106497240  antigen-presenting glycoprotein CD1d-like [KO:K06448]
106493051  T-cell surface glycoprotein CD1a-like [KO:K06448]
106493052  T-cell surface glycoprotein CD1b-3-like [KO:K06448]
106493053  antigen-presenting glycoprotein CD1d-like [KO:K06448]
106488125  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
106492770  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
106489552  YBX3; Y-box binding protein 3 [KO:K06099]
106490508  SYMPK; symplekin [KO:K06100]
106498229  CCND1; cyclin D1 [KO:K04503]
106486153  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
106494897  RUNX1; runt related transcription factor 1 [KO:K08367]
106487231  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
106500025  SLC9A3R1; SLC9A3 regulator 1 [KO:K13365]
106497999  EZR; ezrin [KO:K08007]
106500446  RDX; radixin [KO:K05762]
106493759  MSN; moesin [KO:K05763]
106485510  PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
106491504  ACTG1; actin gamma 1 [KO:K05692]
106497766  actin, cytoplasmic type 5 [KO:K05692]
106497948  actin, cytoplasmic 1 [KO:K05692]
106488627  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
106497979  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106493368  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106498312  CTTN; cortactin [KO:K06106]
106496135  hematopoietic lineage cell-specific protein-like [KO:K06106]
106500105  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
106485303  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
106498462  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
106500077  actin-related protein 2/3 complex subunit 1A [KO:K05757]
106499062  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
106497655  actin-related protein 2/3 complex subunit 3 [KO:K05756]
106497656  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
106495784  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
106495058  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
106496582  WHAMM; WAS protein homolog associated with actin, golgi membranes and microtubules [KO:K20479]
106499821  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106495612  ARHGEF18; Rho/Rac guanine nucleotide exchange factor 18 [KO:K21066]
106484740  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
106494758  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
106495672  MYL2; myosin light chain 2 [KO:K10351]
106492891  EPB41L4B; erythrocyte membrane protein band 4.1 like 4B [KO:K21111]
106493536  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
106499548  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
106499832  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
106498958  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
106499653  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
106486336  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
106497509  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
106499071  5'-AMP-activated protein kinase subunit gamma-3-like [KO:K07200]
106499072  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
106490284  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
106482581  MYH11; myosin heavy chain 11 [KO:K10352]
106488543  MYH9; myosin heavy chain 9 [KO:K10352]
106493188  MYH10; myosin heavy chain 10 [KO:K10352]
106482123  MYL6; myosin light chain 6 [KO:K12751]
106499912  MYL9; myosin light chain 9 [KO:K12755]
106482185  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
106484601  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
106494996  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
106484245  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like [KO:K05631]
106492674  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like [KO:K05631]
106493569  SYNPO; synaptopodin [KO:K21112]
106498254  ACTN1; actinin alpha 1 [KO:K05699]
106491308  MICALL2; MICAL like 2 [KO:K21068]
106494271  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
106496473  RAB8B; RAB8B, member RAS oncogene family [KO:K07902]
106487219  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
106485263  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
106489947  ITGB1; integrin subunit beta 1 [KO:K05719]
106487335  AFDN; afadin, adherens junction formation factor [KO:K05702]
106484412  TJP2; tight junction protein 2 [KO:K06098]
106491974  rap guanine nucleotide exchange factor 2 [KO:K08018]
106490784  RAP2C; RAP2C, member of RAS oncogene family [KO:K07839]
106499170  tubulin alpha-5 chain-like [KO:K07374]
106500247  tubulin alpha-8 chain [KO:K07374]
106492952  tubulin alpha-1B chain-like [KO:K07374]
106492953  tubulin alpha-1B chain-like [KO:K07374]
106491706  tubulin alpha-1D chain-like [KO:K07374]
106491708  tubulin alpha chain-like [KO:K07374]
106499169  tubulin alpha-5 chain [KO:K07374]
106499235  tubulin alpha-1B chain [KO:K07374]
106484196  tubulin alpha-3 chain [KO:K07374]
106488573  TUBA8; tubulin alpha 8 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
aam04520  Adherens junction
aam04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

DBGET integrated database retrieval system