KEGG   PATHWAY: aam04810
Entry
aam04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Apteryx mantelli mantelli (North Island brown kiwi)
Class
Cellular Processes; Cell motility
Pathway map
aam04810  Regulation of actin cytoskeleton
aam04810

Other DBs
GO: 0030036
Organism
Apteryx mantelli mantelli (North Island brown kiwi) [GN:aam]
Gene
106482002  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
106482005  GSN; gelsolin [KO:K05768]
106482012  C5; complement C5 [KO:K03994]
106482083  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
106482185  [KO:K12757]
106482222  KNG1; kininogen 1 [KO:K03898]
106482245  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
106482268  [KO:K05725] [EC:2.7.10.2]
106482280  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
106482513  MYL5; myosin light chain 5 [KO:K12753]
106482581  MYH11; myosin heavy chain 11 [KO:K10352]
106482711  ENAH; enabled homolog (Drosophila) [KO:K05746]
106482835  CFL2; cofilin 2 [KO:K05765]
106482949  BDKRB2; bradykinin receptor B2 [KO:K03916]
106482950  BDKRB1; bradykinin receptor B1 [KO:K03915]
106482997  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
106483109  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
106483357  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
106483431  ITGB8; integrin subunit beta 8 [KO:K06591]
106483498  ITGA8; integrin subunit alpha 8 [KO:K06584]
106483528  SCIN; scinderin [KO:K05768]
106483926  [KO:K12754]
106483939  GNA12; G protein subunit alpha 12 [KO:K04346]
106484097  RGCC; regulator of cell cycle [KO:K26108]
106484201  PFN2; profilin 2 [KO:K05759]
106484414  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
106484477  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
106484601  [KO:K12757]
106484740  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
106484744  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
106484756  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
106484829  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
106484848  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
106485268  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
106485303  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
106485378  [KO:K06493]
106485498  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
106485509  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
106485559  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
106485578  [KO:K06493]
106485674  ITGB4; integrin subunit beta 4 [KO:K06525]
106485939  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
106486017  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
106486247  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
106486256  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
106486265  PXN; paxillin [KO:K05760]
106486519  GNG12; G protein subunit gamma 12 [KO:K04347]
106486559  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
106486689  [KO:K13708]
106486712  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
106486864  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106487128  [KO:K07861]
106487129  [KO:K07861]
106487164  FGF1; fibroblast growth factor 1 [KO:K18496]
106487488  [KO:K05730]
106487545  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
106487663  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106487715  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
106487853  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
106488006  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
106488058  DIAPH1; diaphanous related formin 1 [KO:K05740]
106488061  FGF18; fibroblast growth factor 18 [KO:K04358]
106488354  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
106488469  PDGFB; platelet derived growth factor subunit B [KO:K17386]
106488476  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
106488478  [KO:K17386]
106488543  MYH9; myosin heavy chain 9 [KO:K10352]
106488611  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
106488640  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
106488667  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
106488826  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
106488842  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
106489001  ITGA9; integrin subunit alpha 9 [KO:K06585]
106489297  F2R; coagulation factor II thrombin receptor [KO:K03914]
106489310  FGF16; fibroblast growth factor 16 [KO:K04358]
106489560  FGF6; fibroblast growth factor 6 [KO:K04358]
106489568  FGF23; fibroblast growth factor 23 [KO:K22428]
106489747  WASF1; WAS protein family member 1 [KO:K05753]
106489819  [KO:K06481]
106489947  ITGB1; integrin subunit beta 1 [KO:K05719]
106490011  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
106490061  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
106490079  FGF20; fibroblast growth factor 20 [KO:K04358]
106490172  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
106490391  PFN3; profilin 3 [KO:K05759]
106490395  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
106491145  RHOA; ras homolog family member A [KO:K04513]
106491345  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
106491504  ACTG1; actin gamma 1 [KO:K05692]
106491594  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
106491678  DIAPH3; diaphanous related formin 3 [KO:K05745]
106491689  TMSB4X; thymosin beta 4, X-linked [KO:K05764]
106491847  FGF2; fibroblast growth factor 2 [KO:K18497]
106491877  PDGFC; platelet derived growth factor C [KO:K05450]
106491937  EGF; epidermal growth factor [KO:K04357]
106492199  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106492257  [KO:K05627]
106492271  ITGA11; integrin subunit alpha 11 [KO:K06587]
106492289  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
106492316  ITGB2; integrin subunit beta 2 [KO:K06464]
106492446  ABI2; abl interactor 2 [KO:K05751]
106492453  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
106492613  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
106492755  ITGA3; integrin subunit alpha 3 [KO:K06482]
106492780  [KO:K00920] [EC:2.7.1.149]
106492992  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
106493143  GNA13; G protein subunit alpha 13 [KO:K04639]
106493188  MYH10; myosin heavy chain 10 [KO:K10352]
106493368  [KO:K05704] [EC:2.7.10.2]
106493441  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106493590  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
106493726  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
106493733  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
106493741  ITGAE; integrin subunit alpha E [KO:K06524]
106493759  MSN; moesin [KO:K05763]
106493985  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
106494008  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
106494247  C8G; complement C8 gamma chain [KO:K03999]
106494282  FGF5; fibroblast growth factor 5 [KO:K04358]
106494486  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
106494550  WASF2; WAS protein family member 2 [KO:K05748]
106494707  [KO:K04289]
106494729  FAM49A; family with sequence similarity 49 member A [KO:K27976]
106494758  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
106494786  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
106494862  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
106494979  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
106495058  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
106495086  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
106495130  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
106495273  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106495321  FGF17; fibroblast growth factor 17 [KO:K04358]
106495371  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
106495523  PDGFD; platelet derived growth factor D [KO:K05450]
106495610  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
106495651  [KO:K00907] [EC:2.7.11.18]
106495672  MYL2; myosin light chain 2 [KO:K10351]
106495691  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
106495727  [KO:K05750]
106495784  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
106495808  [KO:K06269] [EC:3.1.3.16]
106495934  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
106496183  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
106496285  FAM49B; family with sequence similarity 49 member B [KO:K27976]
106496545  FGF7; fibroblast growth factor 7 [KO:K04358]
106496616  [KO:K03914]
106496730  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
106496814  DIAPH2; diaphanous related formin 2 [KO:K05741]
106496881  FGF8; fibroblast growth factor 8 [KO:K04358]
106497062  INS; insulin [KO:K04526]
106497122  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
106497200  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
106497327  MYL10; myosin light chain 10 [KO:K12756]
106497378  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
106497655  [KO:K05756]
106497656  [KO:K05756]
106497766  [KO:K05692]
106497948  [KO:K05692]
106497999  EZR; ezrin [KO:K08007]
106498135  FGF3; fibroblast growth factor 3 [KO:K04358]
106498136  FGF19; fibroblast growth factor 19 [KO:K22603]
106498177  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
106498225  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
106498254  ACTN1; actinin alpha 1 [KO:K05699]
106498424  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
106498462  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
106498596  CDC42; cell division cycle 42 [KO:K04393]
106498761  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
106498898  VCL; vinculin [KO:K05700]
106498960  C8A; complement C8 alpha chain [KO:K03997]
106498961  C8B; complement C8 beta chain [KO:K03998]
106499024  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
106499039  [KO:K06588]
106499040  [KO:K06588]
106499062  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
106499121  ITGA4; integrin subunit alpha 4 [KO:K06483]
106499128  ITGAV; integrin subunit alpha V [KO:K06487]
106499136  ITGB6; integrin subunit beta 6 [KO:K06589]
106499141  MRAS; muscle RAS oncogene homolog [KO:K07831]
106499152  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106499178  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
106499236  NCKAP1; NCK associated protein 1 [KO:K05750]
106499243  ITGA6; integrin subunit alpha 6 [KO:K06485]
106499441  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
106499514  C6; complement C6 [KO:K03995]
106499515  FGF10; fibroblast growth factor 10 [KO:K04358]
106499519  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
106499555  C7; complement C7 [KO:K03996]
106499577  C9; complement C9 [KO:K04000]
106499585  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
106499697  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
106499912  MYL9; myosin light chain 9 [KO:K12755]
106499982  ITGA2; integrin subunit alpha 2 [KO:K06481]
106500077  [KO:K05757]
106500105  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
106500202  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
106500257  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
106500403  SPATA13; spermatogenesis associated 13 [KO:K05769]
106500410  FGF9; fibroblast growth factor 9 [KO:K04358]
106500446  RDX; radixin [KO:K05762]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
aam04010  MAPK signaling pathway
aam04510  Focal adhesion
aam04520  Adherens junction
KO pathway
ko04810   

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