KEGG   PATHWAY: achc04514
Entry
achc04514                   Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Aquila chrysaetos chrysaetos (golden eagle)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
achc04514  Cell adhesion molecule (CAM) interaction
achc04514

Other DBs
GO: 0050839
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115333507  CLDN2; claudin-2 [KO:K06087]
115333723  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
115333757  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
115333785  SLITRK4; SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
115333829  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
115333939  CD40LG; CD40 ligand isoform X1 [KO:K03161]
115334491  CD99; CD99 antigen [KO:K06520]
115334600  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
115334651  CLDN34; claudin-34 [KO:K06087]
115334898  NFASC; neurofascin isoform X1 [KO:K06757]
115334978  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
115335163  NTNG2; netrin-G2 isoform X1 [KO:K16359]
115335201  CNTN2; contactin-2 isoform X1 [KO:K06760]
115335802  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
115336381  [KO:K06087]
115336451  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
115337013  VCAN; versican core protein isoform X1 [KO:K06793]
115337299  CD274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]
115337486  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
115338200  [KO:K06752]
115338201  [KO:K06752]
115338202  [KO:K06752]
115338203  [KO:K06752]
115338204  [KO:K06752]
115338205  [KO:K06752]
115338208  [KO:K06752]
115338209  [KO:K06752]
115338300  [KO:K06751]
115338306  [KO:K06751]
115338357  CLDN7; LOW QUALITY PROTEIN: claudin-7 [KO:K06087]
115338644  NRXN3; neurexin 3 isoform X1 [KO:K07377]
115338768  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
115338779  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
115338793  SIGLEC1; LOW QUALITY PROTEIN: sialoadhesin [KO:K06548]
115338872  CNTNAP2; contactin-associated protein-like 2 isoform X1 [KO:K07380]
115338896  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
115339345  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
115339385  SDC4; syndecan-4 isoform X1 [KO:K16338]
115339446  CDH4; LOW QUALITY PROTEIN: cadherin-4 [KO:K06797]
115339665  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
115339680  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
115339702  CLDN12; claudin-12 [KO:K06087]
115340204  CD226; CD226 antigen isoform X1 [KO:K06567]
115340323  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
115340372  CDH2; cadherin-2 isoform X1 [KO:K06736]
115340533  SDC2; syndecan-2 [KO:K16336]
115341131  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
115341188  NEO1; neogenin isoform X1 [KO:K06766]
115341361  CNTN1; contactin-1 [KO:K06759]
115341526  [KO:K06539]
115341644  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
115341695  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
115342287  CD276; CD276 antigen isoform X1 [KO:K06746]
115342518  ITGA4; integrin alpha-4 [KO:K06483]
115342642  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
115342916  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
115343024  CLDN23; claudin-23 [KO:K06087]
115343062  [KO:K06087]
115343262  ITGB2; integrin beta-2 [KO:K06464]
115343263  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
115343351  CLDN19; claudin-19 [KO:K06087]
115343361  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
115343399  [KO:K06713]
115343517  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
115343538  [KO:K05412]
115343541  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
115343718  ALCAM; CD166 antigen isoform X1 [KO:K06547]
115343783  NECTIN3; nectin-3 isoform X1 [KO:K06592]
115343794  CLDN14; claudin-14 [KO:K06087]
115343798  [KO:K06087]
115343799  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
115343914  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
115344048  ICOSLG; ICOS ligand [KO:K06710]
115344115  [KO:K06747]
115344118  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
115344132  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
115344135  [KO:K06087]
115344140  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
115344175  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
115344179  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
115344261  ESAM; LOW QUALITY PROTEIN: endothelial cell-selective adhesion molecule [KO:K06787]
115344318  NCAM1; LOW QUALITY PROTEIN: neural cell adhesion molecule 1 [KO:K06491]
115344392  CADM1; LOW QUALITY PROTEIN: cell adhesion molecule 1 [KO:K06781]
115344462  JAML; junctional adhesion molecule-like isoform X1 [KO:K28137]
115344495  NECTIN1; LOW QUALITY PROTEIN: nectin-1 [KO:K06081]
115344596  JAM3; junctional adhesion molecule C [KO:K06785]
115344616  CNTNAP1; LOW QUALITY PROTEIN: contactin-associated protein 1 [KO:K07379]
115344658  CLDN20; claudin-20 [KO:K06087]
115344889  CLDN25; putative claudin-25 [KO:K06087]
115345343  CDH15; LOW QUALITY PROTEIN: cadherin-15 [KO:K06809]
115345740  GLG1; Golgi apparatus protein 1 [KO:K06816]
115346087  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
115346333  CDH5; cadherin-5 [KO:K06533]
115346366  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
115346395  CLDN5; claudin-5 [KO:K06087]
115346507  [KO:K05689]
115346508  CDH3; LOW QUALITY PROTEIN: cadherin-3 [KO:K06796]
115346563  MPZ; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
115346623  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
115346640  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
115346924  SLITRK3; LOW QUALITY PROTEIN: SLIT and NTRK-like protein 3 [KO:K25834]
115347249  PDCD1; programmed cell death protein 1 isoform X1 [KO:K06744]
115347348  CLDN18; claudin-18 isoform X1 [KO:K06087]
115347376  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
115347458  CLDN1; claudin-1 [KO:K06087]
115347592  CLDN11; claudin-11 [KO:K06087]
115347613  [KO:K06087]
115347619  [KO:K06087]
115347620  [KO:K06087]
115347667  CLDN16; claudin-16 isoform X1 [KO:K06087]
115347684  CLDN3; LOW QUALITY PROTEIN: claudin-3 [KO:K06087]
115348211  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268]
115348682  [KO:K06496]
115348705  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
115348938  NTNG1; netrin-G1 isoform X1 [KO:K07522]
115348953  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
115349116  MADCAM1; mucosal addressin cell adhesion molecule 1 isoform X1 [KO:K06779]
115349153  NEGR1; neuronal growth regulator 1 isoform X1 [KO:K06775]
115349171  OCLN; occludin [KO:K06088]
115349175  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X2 [KO:K06478] [EC:3.1.3.48]
115349418  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
115349674  SELE; E-selectin isoform X1 [KO:K06494]
115350036  NRXN1; neurexin-1 isoform X1 [KO:K07377]
115350745  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
115350747  SLITRK5; LOW QUALITY PROTEIN: SLIT and NTRK-like protein 5 [KO:K25836]
115350765  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
115350772  CLDN10; claudin-10 isoform X1 [KO:K06087]
115351263  SDC1; syndecan-1 [KO:K06257]
115351399  ITGB7; integrin beta-7 [KO:K06590]
115351619  CD6; T-cell differentiation antigen CD6 [KO:K06456]
115351933  SDC3; syndecan-3 [KO:K16337]
115353000  [KO:K06087]
121233138  [KO:K10784]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
achc04520  Adherens junction
achc04530  Tight junction
KO pathway
ko04514   

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