KEGG   PATHWAY: ajm04514
Entry
ajm04514                    Pathway                                
Name
Cell adhesion molecules - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ajm04514  Cell adhesion molecules
ajm04514

Other DBs
GO: 0050839
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119041717  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
119041724  CD2; LOW QUALITY PROTEIN: T-cell surface antigen CD2 [KO:K06449]
119038096  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
119059210  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
119059148  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
119048043  CD274; programmed cell death 1 ligand 1 [KO:K06745]
119064348  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
119046982  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
119064388  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
119058771  ICOSLG; ICOS ligand isoform X1 [KO:K06710]
119064376  ICOS; inducible T-cell costimulator [KO:K06713]
119038537  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
119040562  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119040793  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119040794  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119052984  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
119052987  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
119060698  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
119061214  H-2 class II histocompatibility antigen, A-D beta chain-like [KO:K06752]
119062087  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119055692  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119055693  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
119055694  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119048626  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
119056744  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119056745  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119049925  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119057940  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119048495  uncharacterized protein LOC119048495 [KO:K10785]
119048496  uncharacterized protein LOC119048496 [KO:K10785]
119060419  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
119035307  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
119035444  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
119035883  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119037417  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037803  HLA class I histocompatibility antigen, C alpha chain-like [KO:K06751]
119037804  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
119037805  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119037806  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037808  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
119037809  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119037811  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
119037812  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
119037813  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037822  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119037824  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
119042380  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119058998  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119052950  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
119052964  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119052978  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
119053723  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119055211  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
119048072  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119063032  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119063033  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119055989  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119056406  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119056410  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119056413  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119065069  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
119065880  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065881  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065882  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065883  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119034509  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
119034510  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
119048044  PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708]
119041303  CD276; CD276 antigen [KO:K06746]
119041723  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
119060937  PDCD1; programmed cell death protein 1 isoform X1 [KO:K06744]
119063314  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
119058100  CD40LG; CD40 ligand [KO:K03161]
119058049  ALCAM; CD166 antigen isoform X1 [KO:K06547]
119043702  CD6; T-cell differentiation antigen CD6 [KO:K06456]
119034841  PVR; poliovirus receptor [KO:K06539]
119049511  CD226; CD226 antigen isoform X1 [KO:K06567]
119034836  NECTIN2; nectin-2 isoform X1 [KO:K06531]
119043039  TIGIT; T-cell immunoreceptor with Ig and ITIM domains isoform X1 [KO:K16350]
119041144  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
119058752  ITGB2; integrin beta-2 [KO:K06464]
119037076  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
119036292  ICAM2; intercellular adhesion molecule 2 isoform X1 [KO:K06523]
119037073  ICAM3; intercellular adhesion molecule 3 isoform X1 [KO:K06486]
119037352  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
119053401  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
119051167  SIGLEC1; sialoadhesin [KO:K06548]
119058843  SPN; leukosialin [KO:K06477]
119052772  NECTIN3; nectin-3 isoform X1 [KO:K06592]
119054545  CLDN12; claudin-12 [KO:K06087]
119043453  CLDN11; claudin-11 [KO:K06087]
119035704  CLDN14; claudin-14 [KO:K06087]
119044714  CLDN15; claudin-15 isoform X1 [KO:K06087]
119044873  CLDN18; claudin-18 isoform X1 [KO:K06087]
119043593  CLDN2; claudin-2 [KO:K06087]
119036800  CLDN23; claudin-23 [KO:K06087]
119036844  claudin-22-like [KO:K06087]
119036914  putative claudin-24 [KO:K06087]
119037144  CLDN7; claudin-7 [KO:K06087]
119039096  CLDN1; claudin-1 [KO:K06087]
119039123  CLDN16; claudin-16 isoform X1 [KO:K06087]
119039687  CLDN10; claudin-10 isoform X1 [KO:K06087]
119034934  CLDN20; claudin-20 [KO:K06087]
119052477  CLDN19; claudin-19 [KO:K06087]
119053677  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
119061077  CLDN8; claudin-8 [KO:K06087]
119061088  CLDN17; claudin-17 [KO:K06087]
119046451  CLDN5; claudin-5 [KO:K06087]
119054898  claudin-23-like [KO:K06087]
119056253  CLDN6; claudin-6 [KO:K06087]
119056280  CLDN9; claudin-9 [KO:K06087]
119056363  CLDN4; claudin-4 [KO:K06087]
119056372  CLDN3; claudin-3 [KO:K06087]
119058383  CLDN34; claudin-34 [KO:K06087]
119044360  occludin-like [KO:K06088]
119052801  F11R; junctional adhesion molecule A [KO:K06089]
119056737  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
119044057  JAM3; junctional adhesion molecule C [KO:K06785]
119041074  ESAM; endothelial cell-selective adhesion molecule isoform X1 [KO:K06787]
119061896  CDH5; cadherin-5 isoform X1 [KO:K06533]
119036279  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
119045651  CD99; CD99 antigen [KO:K06520]
119055208  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
119038027  integrin alpha-M-like isoform X1 [KO:K06461]
119046040  P-selectin glycoprotein ligand 1 [KO:K06544]
119057472  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
119065450  P-selectin [KO:K06496]
119037762  ITGA4; integrin alpha-4 [KO:K06483]
119043116  ITGB1; integrin beta-1 [KO:K05719]
119051441  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
119054911  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
119043505  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
119044618  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
119065415  SELL; L-selectin isoform X1 [KO:K06495]
119058029  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
119048936  GLG1; LOW QUALITY PROTEIN: Golgi apparatus protein 1 [KO:K06816]
119065459  SELE; E-selectin [KO:K06494]
119050788  NECTIN1; nectin-1 [KO:K06081]
119036169  CDH2; cadherin-2 [KO:K06736]
119061340  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
119062241  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
119053466  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
119050847  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
119045306  NEGR1; neuronal growth regulator 1 [KO:K06775]
119054582  NTNG1; netrin-G1 isoform X1 [KO:K07522]
119064487  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
119059023  NTNG2; netrin-G2 isoform X1 [KO:K16359]
119065631  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
119052184  PTPRF; receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
119052040  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
119053973  SDC1; syndecan-1 [KO:K06257]
119038580  SDC2; syndecan-2 [KO:K16336]
119052295  SDC3; syndecan-3 [KO:K16337]
119063194  SDC4; syndecan-4 [KO:K16338]
119042993  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
119062840  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
119046313  ITGA8; integrin alpha-8 [KO:K06584]
119059088  neurexin-3 [KO:K07377]
119060874  NRXN1; neurexin-1 isoform X1 [KO:K07377]
119056385  neurexin-3-like [KO:K07377]
119049303  neurexin-3-like [KO:K07377]
119050242  NRXN2; neurexin-2-beta isoform X1 [KO:K07377]
119035400  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
119037162  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
119055445  neuroligin-1 [KO:K07378]
119058379  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
119063726  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
119049241  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
119034712  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
119046945  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
119061709  SLIT and NTRK-like protein 5 [KO:K25836]
119064619  SLIT and NTRK-like protein 5 [KO:K25836]
119039430  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
119057848  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
119038788  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
119064511  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
119051602  CNTN1; contactin-1 [KO:K06759]
119050937  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
119056808  CNTN2; contactin-2 [KO:K06760]
119056822  NFASC; neurofascin isoform X1 [KO:K06757]
119051977  CNTNAP1; contactin-associated protein 1 [KO:K07379]
119062825  contactin-associated protein-like 5 [KO:K07380]
119050995  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
119052491  MPZ; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
119037355  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
119061846  CDH1; cadherin-1 [KO:K05689]
119047505  VCAN; versican core protein isoform X1 [KO:K06793]
119053637  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
119061945  CDH3; cadherin-3 [KO:K06796]
119055377  CDH4; cadherin-4 isoform X1 [KO:K06797]
119047028  CDH15; cadherin-15 [KO:K06809]
119041313  NEO1; neogenin isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
ajm04520  Adherens junction
ajm04530  Tight junction
ajm04610  Complement and coagulation cascades
ajm04660  T cell receptor signaling pathway
ajm04670  Leukocyte transendothelial migration
KO pathway
ko04514   
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