KEGG   PATHWAY: bacu04530
Entry
bacu04530                   Pathway                                
Name
Tight junction - Balaenoptera acutorostrata scammoni (minke whale)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
bacu04530  Tight junction
bacu04530

Other DBs
GO: 0005923
Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
102997556  CRB3; crumbs 3, cell polarity complex component [KO:K06090]
103004896  claudin-3-like [KO:K06087]
103015594  CLDN19; claudin 19 [KO:K06087]
102998551  CLDN7; claudin 7 [KO:K06087]
103005733  CLDN6; claudin 6 [KO:K06087]
103006394  CLDN9; claudin 9 [KO:K06087]
103017666  CLDN20; claudin 20 [KO:K06087]
103001230  CLDN4; claudin 4 [KO:K06087]
103001499  CLDN3; claudin 3 [KO:K06087]
103017757  CLDN15; claudin 15 [KO:K06087]
103013250  CLDN5; claudin 5 [KO:K06087]
103006570  CLDN10; claudin 10 [KO:K06087]
103004023  CLDN16; claudin 16 [KO:K06087]
103004783  CLDN1; claudin 1 [KO:K06087]
103016511  CLDN22; claudin 22 [KO:K06087]
103019842  CLDN2; claudin 2 [KO:K06087]
103007857  CLDN24; claudin 24 [KO:K06087]
103019538  CLDN18; claudin 18 [KO:K06087]
103009095  CLDN25; claudin 25 [KO:K06087]
102997666  CLDN17; claudin 17 [KO:K06087]
102997953  CLDN8; claudin 8 [KO:K06087]
103018274  CLDN23; claudin 23 [KO:K06087]
103002558  CLDN11; claudin 11 [KO:K06087]
103008854  CLDN14; claudin 14 [KO:K06087]
103018287  CLDN12; claudin 12 [KO:K06087]
103000523  OCLN; occludin [KO:K06088]
103020849  F11R; F11 receptor [KO:K06089]
103003967  JAM2; junctional adhesion molecule 2 [KO:K06735]
103020702  JAM3; junctional adhesion molecule 3 [KO:K06785]
103015434  BVES; blood vessel epicardial substance [KO:K21108]
103008817  CDC42; cell division cycle 42 [KO:K04393]
103002939  partitioning defective 6 homolog beta-like [KO:K06093]
103010954  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
103021121  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
103020250  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
103003701  MPP5; membrane palmitoylated protein 5 [KO:K06091]
103004644  MPP4; membrane palmitoylated protein 4 [KO:K21109]
103008721  TJP3; tight junction protein 3 [KO:K06097]
103011460  PATJ; PATJ, crumbs cell polarity complex component [KO:K06092]
103014738  MPDZ; multiple PDZ domain crumbs cell polarity complex component [KO:K06095]
103004909  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
103003679  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
103014496  AMOT; angiomotin [KO:K16819]
103015042  AMOTL1; angiomotin like 1 [KO:K06104]
103002340  AMOTL2; angiomotin like 2 [KO:K06104]
103014679  ARHGAP17; Rho GTPase activating protein 17 [KO:K20638]
103007995  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103007813  NF2; neurofibromin 2 [KO:K16684]
103000713  LLGL1; LLGL1, scribble cell polarity complex component [KO:K06094]
103012538  LLGL2; LLGL2, scribble cell polarity complex component [KO:K06094]
103001527  DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
103005200  SCRIB; scribbled planar cell polarity protein [KO:K16175]
103018989  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
103000342  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
103019215  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
103019457  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
103017366  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
103003377  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
103020854  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
103015446  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
103001451  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
103004935  PARD3; par-3 family cell polarity regulator [KO:K04237]
103016623  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
103014304  tight junction protein ZO-1-like [KO:K05701]
103002279  TJAP1; tight junction associated protein 1 [KO:K06105]
103008780  DLG2; discs large MAGUK scaffold protein 2 [KO:K12075]
103012048  DLG3; discs large MAGUK scaffold protein 3 [KO:K21098]
103010368  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
103005326  NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
103021145  CGN; cingulin [KO:K06102]
103006703  CGNL1; cingulin like 1 [KO:K21110]
103009184  ARHGEF2; Rho/Rac guanine nucleotide exchange factor 2 [KO:K12791]
103019793  RHOA; ras homolog family member A [KO:K04513]
103000242  GATA4; GATA binding protein 4 [KO:K09183]
102997979  MARVELD3; MARVEL domain containing 3 [KO:K21099]
103002185  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102997603  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103007019  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103008728  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103001311  transcription factor AP-1-like [KO:K04448]
103014668  transcription factor AP-1-like [KO:K04448]
103015166  CD1E; CD1e molecule [KO:K06448]
103015438  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
103016014  CD1D; CD1d molecule [KO:K06448]
103004581  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
103000540  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103010593  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
103008148  YBX3; Y-box binding protein 3 [KO:K06099]
103017674  SYMPK; symplekin [KO:K06100]
102999134  PCNA; proliferating cell nuclear antigen [KO:K04802]
103013404  CCND1; cyclin D1 [KO:K04503]
103002640  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
103006498  RUNX1; runt related transcription factor 1 [KO:K08367]
103014136  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
102999840  SLC9A3R1; SLC9A3 regulator 1 [KO:K13365]
103012336  EZR; ezrin [KO:K08007]
102998582  RDX; radixin [KO:K05762]
103015689  MSN; moesin [KO:K05763]
103006250  PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
103005004  ACTG1; actin gamma 1 [KO:K05692]
103015338  ACTB; actin beta [KO:K05692]
103001906  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102999328  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103011683  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103001801  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103018861  HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
103015814  CTTN; cortactin [KO:K06106]
102999770  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
103007988  ACTR3B; ARP3 actin-related protein 3 homolog B (yeast) [KO:K18584]
103019624  actin-related protein 3-like [KO:K18584]
102999755  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
103000575  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
103014870  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
102998297  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
102999968  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
102997867  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
103008913  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
103011812  WHAMM; WAS protein homolog associated with actin, golgi membranes and microtubules [KO:K20479]
103013907  WAS; Wiskott-Aldrich syndrome [KO:K05747]
103012549  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
103000011  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103008319  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103003587  RAB13; RAB13, member RAS oncogene family [KO:K06109]
103011190  ARHGEF18; Rho/Rac guanine nucleotide exchange factor 18 [KO:K21066]
103002971  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
102999355  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103016555  MYL2; myosin light chain 2 [KO:K10351]
103020609  EPB41L4B; erythrocyte membrane protein band 4.1 like 4B [KO:K21111]
103015566  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
103018222  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
103019090  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
103019135  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
103015065  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
103000853  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
102999310  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
103017735  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
103010023  MYH11; myosin heavy chain 11 [KO:K10352]
103012335  MYH9; myosin heavy chain 9 [KO:K10352]
103016076  MYH10; myosin heavy chain 10 [KO:K10352]
103017736  MYL6B; myosin light chain 6B [KO:K12751]
103018400  MYL6; myosin light chain 6 [KO:K12751]
103009483  MYL9; myosin light chain 9 [KO:K12755]
103010250  myosin regulatory light polypeptide 9-like [KO:K12757]
103010734  MYL12B; myosin light chain 12B [KO:K12757]
103019582  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
103013603  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
103015243  SYNPO; synaptopodin [KO:K21112]
103010879  ACTN1; actinin alpha 1 [KO:K05699]
103018854  ACTN4; actinin alpha 4 [KO:K05699]
103007351  MICALL2; MICAL like 2 [KO:K21068]
103008180  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
103014677  RAB8B; RAB8B, member RAS oncogene family [KO:K07902]
103001438  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
103017880  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
103008019  ITGB1; integrin subunit beta 1 [KO:K05719]
103000660  TJP2; tight junction protein 2 [KO:K06098]
103005459  rap guanine nucleotide exchange factor 2-like [KO:K08018]
103017908  RAP2C; RAP2C, member of RAS oncogene family [KO:K07839]
103001912  MARVELD2; MARVEL domain containing 2 [KO:K17291]
103007507  tubulin alpha-1D chain-like [KO:K07374]
103007004  TUBA4A; tubulin alpha 4a [KO:K07374]
103018473  tubulin alpha-3 chain-like [KO:K07374]
103019471  tubulin alpha-3 chain-like [KO:K07374]
103011769  TUBAL3; tubulin, alpha-like 3 [KO:K07374]
103018852  TUBA1B; tubulin alpha 1b [KO:K07374]
103019847  TUBA1A; tubulin alpha 1a [KO:K07374]
103020122  TUBA1C; tubulin alpha 1c [KO:K07374]
103020611  tubulin alpha-1B chain-like [KO:K07374]
103011731  TUBA8; tubulin alpha 8 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
bacu04520  Adherens junction
bacu04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

DBGET integrated database retrieval system