KEGG   PATHWAY: bmj00260
Entry
bmj00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia multivorans ATCC 17616 (Tohoku)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bmj00260  Glycine, serine and threonine metabolism
bmj00260

Module
bmj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bmj00260]
bmj_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bmj00260]
bmj_M00555  Betaine biosynthesis, choline => betaine [PATH:bmj00260]
bmj_M00621  Glycine cleavage system [PATH:bmj00260]
bmj_M00919  Ectoine degradation, ectoine => aspartate [PATH:bmj00260]
bmj_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bmj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia multivorans ATCC 17616 (Tohoku) [GN:bmj]
Gene
BMULJ_02048  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
BMULJ_03885  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BMULJ_01824  thrA; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BMULJ_03637  thrB; homoserine kinase type II [KO:K02204] [EC:2.7.1.39]
BMULJ_01823  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BMULJ_05215  ltaA; threonine aldolase [KO:K01620] [EC:4.1.2.48]
BMULJ_00657  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BMULJ_04971  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BMULJ_00280  serA; D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BMULJ_01714  gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BMULJ_01041  gyaR; glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BMULJ_01898  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
BMULJ_02809  gpm; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BMULJ_00540  gpm; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BMULJ_00101  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BMULJ_03811  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BMULJ_00977  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BMULJ_01750  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BMULJ_00656  short-chain alcohol dehydrogenase of unknown specificity [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BMULJ_03200  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BMULJ_03201  tdh; threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BMULJ_03124  gcvP; glycine dehydrogenase subunit 1 [KO:K00281] [EC:1.4.4.2]
BMULJ_03122  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
BMULJ_01495  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BMULJ_02119  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BMULJ_04552  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BMULJ_03123  gcvH; glycine cleavage system H protein [KO:K02437]
BMULJ_02247  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BMULJ_04981  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BMULJ_04980  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BMULJ_03253  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BMULJ_03319  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BMULJ_03737  NAD-dependent aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BMULJ_04964  ring-hydroxylating dioxygenase large subunit [KO:K00479] [EC:1.14.13.251]
BMULJ_04963  hcaD; ferredoxin-NAD+ reductase [KO:K21832] [EC:1.14.13.251]
BMULJ_04968  fadH; NADPH2-dependent 2,4-dienoyl-CoA reductase [KO:K21833] [EC:1.5.7.3]
BMULJ_04967  heterodisulfide reductase [KO:K21834]
BMULJ_04966  fixB; electron transfer flavoprotein alpha subunit [KO:K25960]
BMULJ_04965  fixA; electron transfer flavoprotein beta subunit [KO:K25961]
BMULJ_05011  soxA; sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BMULJ_05013  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BMULJ_05010  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BMULJ_05012  soxD; sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BMULJ_03126  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
BMULJ_05014  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
BMULJ_05385  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BMULJ_01921  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BMULJ_02699  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BMULJ_02127  racD; aspartate racemase [KO:K25316] [EC:5.1.1.10]
BMULJ_03891  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BMULJ_03889  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BMULJ_04419  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
BMULJ_05387  pepQ; X-Pro dipeptidase [KO:K15783] [EC:3.5.4.44]
BMULJ_05388  deacylase [KO:K15784] [EC:3.5.1.125]
BMULJ_05391  putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase [KO:K15785] [EC:2.6.1.76]
BMULJ_05390  gabD; NADP-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bmj00010  Glycolysis / Gluconeogenesis
bmj00020  Citrate cycle (TCA cycle)
bmj00230  Purine metabolism
bmj00250  Alanine, aspartate and glutamate metabolism
bmj00270  Cysteine and methionine metabolism
bmj00290  Valine, leucine and isoleucine biosynthesis
bmj00300  Lysine biosynthesis
bmj00330  Arginine and proline metabolism
bmj00460  Cyanoamino acid metabolism
bmj00470  D-Amino acid metabolism
bmj00564  Glycerophospholipid metabolism
bmj00600  Sphingolipid metabolism
bmj00620  Pyruvate metabolism
bmj00630  Glyoxylate and dicarboxylate metabolism
bmj00640  Propanoate metabolism
bmj00680  Methane metabolism
bmj00860  Porphyrin metabolism
bmj00920  Sulfur metabolism
KO pathway
ko00260   
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