KEGG   PATHWAY: bspo00260
Entry
bspo00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Brevibacterium spongiae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bspo00260  Glycine, serine and threonine metabolism
bspo00260

Module
bspo_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bspo00260]
bspo_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bspo00260]
bspo_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:bspo00260]
bspo_M00555  Betaine biosynthesis, choline => betaine [PATH:bspo00260]
bspo_M00621  Glycine cleavage system [PATH:bspo00260]
bspo_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bspo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Brevibacterium spongiae [GN:bspo]
Gene
L1F31_04955  aspartate kinase [KO:K00928] [EC:2.7.2.4]
L1F31_04960  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
L1F31_08290  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
L1F31_08300  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
L1F31_08295  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
L1F31_13045  beta-eliminating lyase-related protein [KO:K01620] [EC:4.1.2.48]
L1F31_00670  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
L1F31_06160  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
L1F31_04545  glycerate kinase [KO:K00865] [EC:2.7.1.165]
L1F31_15515  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
L1F31_12495  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
L1F31_15140  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
L1F31_09750  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
L1F31_03970  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
L1F31_02490  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
L1F31_02495  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
L1F31_09160  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
L1F31_02500  gcvH; glycine cleavage system protein GcvH [KO:K02437]
L1F31_10995  gcvH; glycine cleavage system protein GcvH [KO:K02437]
L1F31_00650  aminopeptidase P family protein [KO:K08688] [EC:3.5.3.3]
L1F31_11215  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
L1F31_11210  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
L1F31_13415  homocysteine S-methyltransferase family protein [KO:K00544] [EC:2.1.1.5]
L1F31_01020  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
L1F31_18140  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
L1F31_01025  iron-sulfur cluster-binding domain-containing protein [KO:K21832] [EC:1.14.13.251]
L1F31_18135  FAD-binding oxidoreductase [KO:K21832] [EC:1.14.13.251]
L1F31_01030  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
L1F31_03180  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
L1F31_00685  2Fe-2S iron-sulfur cluster-binding protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
L1F31_00675  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
L1F31_00690  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
L1F31_00680  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
L1F31_00695  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
L1F31_02505  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
L1F31_00730  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
L1F31_16305  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
L1F31_18170  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
L1F31_11475  amino acid racemase [KO:K25316] [EC:5.1.1.10]
L1F31_10015  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
L1F31_10020  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
L1F31_02515  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
L1F31_02510  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
L1F31_02520  ectoine synthase [KO:K06720] [EC:4.2.1.108]
L1F31_13860  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
L1F31_10540  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bspo00010  Glycolysis / Gluconeogenesis
bspo00020  Citrate cycle (TCA cycle)
bspo00230  Purine metabolism
bspo00250  Alanine, aspartate and glutamate metabolism
bspo00270  Cysteine and methionine metabolism
bspo00290  Valine, leucine and isoleucine biosynthesis
bspo00300  Lysine biosynthesis
bspo00330  Arginine and proline metabolism
bspo00460  Cyanoamino acid metabolism
bspo00470  D-Amino acid metabolism
bspo00564  Glycerophospholipid metabolism
bspo00620  Pyruvate metabolism
bspo00630  Glyoxylate and dicarboxylate metabolism
bspo00640  Propanoate metabolism
bspo00680  Methane metabolism
bspo00860  Porphyrin metabolism
bspo00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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