KEGG   PATHWAY: bxb00230
Entry
bxb00230                    Pathway                                
Name
Purine metabolism - Paraburkholderia xenovorans LB400
Class
Metabolism; Nucleotide metabolism
Pathway map
bxb00230  Purine metabolism
bxb00230

Module
bxb_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bxb00230]
bxb_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:bxb00230]
bxb_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:bxb00230]
bxb_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:bxb00230]
bxb_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:bxb00230]
bxb_M00546  Purine degradation, xanthine => urea [PATH:bxb00230]
bxb_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:bxb00230]
bxb_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:bxb00230]
Other DBs
GO: 0006163 0042278
Organism
Paraburkholderia xenovorans LB400 [GN:bxb]
Gene
DR64_901  NUDIX domain protein [KO:K01515] [EC:3.6.1.13 3.6.1.-]
DR64_6826  pgm; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
DR64_7902  pgm; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
DR64_1393  phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III family protein [KO:K15778] [EC:5.4.2.8 5.4.2.2]
DR64_1810  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
DR64_5204  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
DR64_963  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
DR64_2974  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
DR64_1001  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
DR64_4432  purL; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
DR64_1613  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
DR64_2862  purK; phosphoribosylaminoimidazole carboxylase, ATPase subunit [KO:K01589] [EC:6.3.4.18]
DR64_2861  purE; phosphoribosylaminoimidazole carboxylase, catalytic subunit [KO:K01588] [EC:5.4.99.18]
DR64_2860  purC; phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
DR64_2763  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
DR64_2787  purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
DR64_1791  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
DR64_1732  5'-nucleotidase family protein [KO:K01081] [EC:3.1.3.5]
DR64_57  surE; 5'/3'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
DR64_8440  hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
DR64_49  multi-copper polyphenol oxidoreductase laccase family protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
DR64_2692  phosphoribosyl transferase domain protein [KO:K00760] [EC:2.4.2.8]
DR64_3871  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
DR64_3751  nucleoside diphosphate kinase family protein [KO:K00940] [EC:2.7.4.6]
DR64_3064  rdgB; non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [KO:K01519] [EC:3.6.1.66]
DR64_3112  xdhA; xanthine dehydrogenase, small subunit [KO:K13481] [EC:1.17.1.4]
DR64_1562  xdhA; xanthine dehydrogenase, small subunit [KO:K13481] [EC:1.17.1.4]
DR64_3111  xdhB; xanthine dehydrogenase, molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
DR64_1561  xdhB; xanthine dehydrogenase, molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
DR64_6627  molybdopterin-binding domain of aldehyde dehydrogenase family protein [KO:K11177] [EC:1.17.1.4]
DR64_4557  molybdopterin-binding domain of aldehyde dehydrogenase family protein [KO:K11177] [EC:1.17.1.4]
DR64_8583  molybdopterin-binding domain of aldehyde dehydrogenase family protein [KO:K11177] [EC:1.17.1.4]
DR64_6626  FAD binding domain in molybdopterin dehydrogenase family protein [KO:K11178] [EC:1.17.1.4]
DR64_4556  FAD binding domain in molybdopterin dehydrogenase family protein [KO:K11178] [EC:1.17.1.4]
DR64_7245  FAD binding domain in molybdopterin dehydrogenase family protein [KO:K11178] [EC:1.17.1.4]
DR64_8584  FAD binding domain in molybdopterin dehydrogenase family protein [KO:K11178] [EC:1.17.1.4]
DR64_6625  [2Fe-2S] binding domain protein [KO:K13483]
DR64_4555  [2Fe-2S] binding domain protein [KO:K13483]
DR64_8585  [2Fe-2S] binding domain protein [KO:K13483]
DR64_2184  peptidase C26 family protein [KO:K01951] [EC:6.3.5.2]
DR64_3873  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
DR64_3108  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
DR64_3067  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
DR64_7012  ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [KO:K00525] [EC:1.17.4.1]
DR64_2697  ribonucleoside-diphosphate reductase, alpha subunit [KO:K00525] [EC:1.17.4.1]
DR64_2698  ribonucleotide reductase, small chain family protein [KO:K00526] [EC:1.17.4.1]
DR64_2531  dgt; dGTPase family protein [KO:K01129] [EC:3.1.5.1]
DR64_3069  RelA/SpoT family protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
DR64_3432  ppx/GppA phosphatase family protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
DR64_3531  RelA/SpoT family protein [KO:K00951] [EC:2.7.6.5]
DR64_6136  hypothetical protein [KO:K01768] [EC:4.6.1.1]
DR64_3765  purA; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
DR64_2702  pfkB carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
DR64_5167  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
DR64_3109  add; adenosine deaminase [KO:K21053] [EC:3.5.4.2]
DR64_2931  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
DR64_3628  calcineurin-like phosphoesterase family protein [KO:K03651] [EC:3.1.4.53]
DR64_1482  apaH; apaH [KO:K01525] [EC:3.6.1.41]
DR64_172  cysC; adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
DR64_1351  cysN; sulfate adenylyltransferase, large subunit [KO:K00956] [EC:2.7.7.4]
DR64_1352  phosphoadenosine phosphosulfate reductase family protein [KO:K00957] [EC:2.7.7.4]
DR64_8334  FAD dependent oxidoreductase family protein [KO:K22879] [EC:1.14.13.113]
DR64_4316  pyridine nucleotide-disulfide oxidoreductase family protein [KO:K22879] [EC:1.14.13.113]
DR64_8313  pyridine nucleotide-disulfide oxidoreductase family protein [KO:K22879] [EC:1.14.13.113]
DR64_4094  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
DR64_4088  uraD; OHCU decarboxylase [KO:K13485] [EC:4.1.1.97]
DR64_4086  asp/Glu/Hydantoin racemase family protein [KO:K16841] [EC:5.1.99.3]
DR64_7692  asp/Glu/Hydantoin racemase family protein [KO:K16841] [EC:5.1.99.3]
DR64_4087  polysaccharide deacetylase family protein [KO:K16842] [EC:3.5.2.5]
DR64_2742  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
DR64_4089  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
DR64_4985  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
DR64_8492  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
DR64_2743  ureidoglycolate hydrolase family protein [KO:K01483] [EC:4.3.2.3]
DR64_4090  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
DR64_5287  ureidoglycolate lyase [KO:K16856] [EC:4.3.2.3]
DR64_1069  fumarylacetoacetate (FAA) hydrolase family protein [KO:K16856] [EC:4.3.2.3]
DR64_1386  ureC; urease, alpha subunit [KO:K01428] [EC:3.5.1.5]
DR64_1385  ureB; urease, beta subunit [KO:K01429] [EC:3.5.1.5]
DR64_1384  ureA; urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
DR64_6370  gamma-glutamyltranspeptidase family protein [KO:K22602] [EC:3.5.1.126]
DR64_4037  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
DR64_7703  amino acid kinase family protein [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
bxb00030  Pentose phosphate pathway
bxb00220  Arginine biosynthesis
bxb00250  Alanine, aspartate and glutamate metabolism
bxb00260  Glycine, serine and threonine metabolism
bxb00340  Histidine metabolism
bxb00630  Glyoxylate and dicarboxylate metabolism
bxb00730  Thiamine metabolism
bxb00740  Riboflavin metabolism
bxb00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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