KEGG   PATHWAY: bxb00260
Entry
bxb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paraburkholderia xenovorans LB400
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bxb00260  Glycine, serine and threonine metabolism
bxb00260

Module
bxb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bxb00260]
bxb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bxb00260]
bxb_M00555  Betaine biosynthesis, choline => betaine [PATH:bxb00260]
bxb_M00621  Glycine cleavage system [PATH:bxb00260]
bxb_M00919  Ectoine degradation, ectoine => aspartate [PATH:bxb00260]
bxb_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bxb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paraburkholderia xenovorans LB400 [GN:bxb]
Gene
DR64_3788  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
DR64_5215  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DR64_85  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DR64_5169  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
DR64_84  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
DR64_4534  beta-eliminating lyase family protein [KO:K01620] [EC:4.1.2.48]
DR64_3475  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DR64_1590  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
DR64_6888  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
DR64_5330  aminotransferase class-V family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
DR64_6305  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
DR64_1946  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DR64_6797  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DR64_7279  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DR64_7724  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DR64_3218  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
DR64_4141  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
DR64_1  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
DR64_6303  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DR64_1859  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DR64_2781  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
DR64_2097  putative d-3-phosphoglycerate dehydrogenase oxidoreductase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DR64_3137  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
DR64_35  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DR64_1591  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
DR64_5350  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
DR64_5349  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
DR64_6842  FAD binding domain protein [KO:K00274] [EC:1.4.3.4]
DR64_2233  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
DR64_2235  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
DR64_3704  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR64_5912  lpd3; dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
DR64_492  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR64_7594  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR64_2234  gcvH; glycine cleavage system H protein [KO:K02437]
DR64_929  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DR64_6895  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
DR64_6894  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DR64_6881  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
DR64_6880  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
DR64_6885  flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
DR64_6884  4Fe-4S dicluster domain protein [KO:K21834]
DR64_6883  electron transfer flavodomain protein [KO:K25960]
DR64_6882  universal stress family protein [KO:K25961]
DR64_6901  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DR64_6903  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DR64_6900  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DR64_6902  soxD; subunit delta of sarcosine oxidase domain protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DR64_2231  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DR64_5439  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DR64_6904  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DR64_1731  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DR64_4195  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DR64_18  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
DR64_8369  eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
DR64_3691  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
DR64_5209  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
DR64_5211  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
DR64_8362  eutD; ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]
DR64_8367  eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
DR64_8364  aminotransferase [KO:K15785] [EC:2.6.1.76]
DR64_8365  aldehyde dehydrogenase family protein [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bxb00010  Glycolysis / Gluconeogenesis
bxb00020  Citrate cycle (TCA cycle)
bxb00230  Purine metabolism
bxb00250  Alanine, aspartate and glutamate metabolism
bxb00270  Cysteine and methionine metabolism
bxb00290  Valine, leucine and isoleucine biosynthesis
bxb00300  Lysine biosynthesis
bxb00330  Arginine and proline metabolism
bxb00460  Cyanoamino acid metabolism
bxb00470  D-Amino acid metabolism
bxb00564  Glycerophospholipid metabolism
bxb00600  Sphingolipid metabolism
bxb00620  Pyruvate metabolism
bxb00630  Glyoxylate and dicarboxylate metabolism
bxb00640  Propanoate metabolism
bxb00680  Methane metabolism
bxb00860  Porphyrin metabolism
bxb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system