KEGG   PATHWAY: caty04514
Entry
caty04514                   Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Cercocebus atys (sooty mangabey)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
caty04514  Cell adhesion molecule (CAM) interaction
caty04514

Other DBs
GO: 0050839
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571814  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
105571823  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
105571832  JAM2; junctional adhesion molecule B [KO:K06735]
105571866  CLDN17; claudin-17 [KO:K06087]
105571867  CLDN8; claudin-8 [KO:K06087]
105572054  CLDN9; claudin-9 [KO:K06087]
105572055  CLDN6; claudin-6 [KO:K06087]
105572392  CLDN2; claudin-2 [KO:K06087]
105572987  CD6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
105573234  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
105573492  NEO1; neogenin isoform X1 [KO:K06766]
105573497  CD276; CD276 antigen isoform X1 [KO:K06746]
105573536  JAM3; junctional adhesion molecule C [KO:K06785]
105573553  CLDN12; claudin-12 [KO:K06087]
105573915  ITGA9; integrin alpha-9 [KO:K06585]
105574085  [KO:K06751]
105574086  [KO:K06751]
105574087  [KO:K06752]
105574103  [KO:K06752]
105574478  CLDN10; claudin-10 isoform X1 [KO:K06087]
105574506  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
105574509  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
105574513  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
105574751  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
105574771  CD99; CD99 antigen isoform X1 [KO:K06520]
105574828  GLG1; Golgi apparatus protein 1 [KO:K06816]
105575000  [KO:K06752]
105575001  [KO:K06752]
105575002  [KO:K06752]
105575005  [KO:K06752]
105575006  [KO:K06752]
105575013  [KO:K06752]
105575014  [KO:K06752]
105575015  [KO:K06752]
105575032  [KO:K06751]
105575053  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
105575193  CLDN16; claudin-16 isoform X1 [KO:K06087]
105575194  CLDN1; claudin-1 [KO:K06087]
105575419  CLDN14; claudin-14 [KO:K06087]
105575513  ICOSLG; ICOS ligand isoform X1 [KO:K06710]
105575545  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
105575603  [KO:K06752]
105575604  [KO:K06752]
105575605  [KO:K06752]
105575607  [KO:K06752]
105575610  [KO:K06751]
105575630  [KO:K06751]
105576220  NFASC; neurofascin isoform X1 [KO:K06757]
105576339  [KO:K06751]
105576630  [KO:K06751]
105576705  [KO:K06751]
105576706  [KO:K06751]
105576707  [KO:K06751]
105576724  [KO:K06752]
105576725  [KO:K06752]
105576726  [KO:K06752]
105576907  [KO:K06751]
105577037  CNTN2; contactin-2 [KO:K06760]
105577084  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
105577184  PDCD1; programmed cell death protein 1 [KO:K06744]
105577481  NRXN2; neurexin-2-beta isoform X1 [KO:K07377]
105578168  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
105578169  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
105578575  SDC1; syndecan-1 [KO:K06257]
105579303  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
105579358  CLDN23; claudin-23 [KO:K06087]
105579682  CNTNAP1; contactin-associated protein 1 isoform X1 [KO:K07379]
105579752  [KO:K06751]
105579809  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105579895  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
105579920  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105580070  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
105580074  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
105580075  ICOS; inducible T-cell costimulator [KO:K06713]
105580282  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
105582138  SIGLEC1; sialoadhesin isoform X1 [KO:K06548]
105582144  CDH1; cadherin-1 [KO:K05689]
105582300  CDH3; cadherin-3 isoform X1 [KO:K06796]
105582465  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
105582467  AMICA1; junctional adhesion molecule-like isoform X1 [KO:K28137]
105582520  PVRL1; nectin-1 isoform X1 [KO:K06081]
105582582  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
105582626  CLDN7; claudin-7 [KO:K06087]
105583039  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
105583128  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
105583409  [KO:K06751]
105583846  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105583891  [KO:K06752]
105584060  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
105584085  CD274; programmed cell death 1 ligand 1 [KO:K06745]
105584087  PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708]
105584618  [KO:K10785]
105584628  [KO:K10785]
105584687  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
105584806  [KO:K06759]
105585184  [KO:K06752]
105586029  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
105586060  CLDN11; claudin-11 [KO:K06087]
105586088  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
105586120  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
105586395  CLDN18; claudin-18 isoform X1 [KO:K06087]
105586506  SDC2; syndecan-2 isoform X1 [KO:K16336]
105586820  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
105587573  CDH5; cadherin-5 [KO:K06533]
105587684  CDH15; cadherin-15 isoform X1 [KO:K06809]
105588250  NTNG1; netrin-G1 isoform X1 [KO:K07522]
105588469  SDC4; syndecan-4 [KO:K16338]
105588507  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
105588652  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
105588666  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
105588673  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
105589122  [KO:K06752]
105589242  MPZ; myelin protein P0 [KO:K06770]
105589311  F11R; LOW QUALITY PROTEIN: junctional adhesion molecule A [KO:K06089]
105589534  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105589715  [KO:K10785]
105589719  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
105589728  CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412]
105589768  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
105590034  CD226; CD226 antigen isoform X1 [KO:K06567]
105590139  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
105590469  [KO:K06752]
105590628  NRXN1; neurexin-1-beta isoform X1 [KO:K07377]
105590754  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
105590766  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
105590912  NRXN3; neurexin 3 isoform X1 [KO:K07377]
105591671  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
105591828  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
105592381  CDH4; LOW QUALITY PROTEIN: cadherin-4 [KO:K06797]
105592626  CDH2; cadherin-2 [KO:K06736]
105592681  CD40LG; CD40 ligand [KO:K03161]
105593352  CLDN4; claudin-4 [KO:K06087]
105593354  CLDN3; claudin-3 [KO:K06087]
105593405  CLDN15; claudin-15 [KO:K06087]
105593589  [KO:K06752]
105593887  [KO:K10784]
105594163  NTNG2; netrin-G2 [KO:K16359]
105594634  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
105594660  CLDN19; claudin-19 isoform X1 [KO:K06087]
105594852  SDC3; syndecan-3 isoform X1 [KO:K16337]
105595115  [KO:K06539]
105595123  PVRL2; nectin-2 isoform X1 [KO:K06531]
105595332  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
105595435  [KO:K06539]
105595489  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
105595574  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
105595582  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
105595863  NEGR1; neuronal growth regulator 1 [KO:K06775]
105596250  PVRL3; nectin-3 isoform X1 [KO:K06592]
105596291  TIGIT; T-cell immunoreceptor with Ig and ITIM domains isoform X1 [KO:K16350]
105596319  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
105596324  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
105597013  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105597291  [KO:K23268]
105597754  CLDN24; putative claudin-24 [KO:K06087]
105597757  CLDN22; claudin-22 [KO:K06087]
105598536  LRRC4; leucine-rich repeat-containing protein 4 isoform X1 [KO:K16351]
105598725  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
105598845  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
105598846  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
105599078  SPN; leukosialin [KO:K06477]
105599122  VCAN; versican core protein isoform X1 [KO:K06793]
105599288  OCLN; LOW QUALITY PROTEIN: occludin [KO:K06088]
105599606  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105599612  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
105599653  ALCAM; CD166 antigen isoform X1 [KO:K06547]
105599804  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
105600036  [KO:K06751]
105600082  [KO:K06751]
105600083  [KO:K06751]
105600160  SELE; E-selectin [KO:K06494]
105600162  SELL; L-selectin isoform X1 [KO:K06495]
105600163  SELP; P-selectin isoform X1 [KO:K06496]
105600305  [KO:K06752]
105600307  [KO:K06752]
105600886  [KO:K06751]
105601249  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
105601289  CLDN5; claudin-5 [KO:K06087]
105601438  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105601445  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
caty04520  Adherens junction
caty04530  Tight junction
caty04610  Complement and coagulation cascades
caty04660  T cell receptor signaling pathway
caty04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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