KEGG   PATHWAY: cery04260
Entry
cery04260                   Pathway                                
Name
Cardiac muscle contraction - Chanodichthys erythropterus (predatory carp)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
cery04260  Cardiac muscle contraction
cery04260

Other DBs
GO: 0060048
Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137001994  tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K10373]
137002051  uqcrb; cytochrome b-c1 complex subunit 7 [KO:K00417]
137002847  tpm4b; tropomyosin 4b isoform X1 [KO:K10375]
137002903  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
137003171  uqcr11; cytochrome b-c1 complex subunit 10 [KO:K00420]
137003274  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
137003439  [KO:K00416]
137004423  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
137004729  cox7a1; cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
137004772  atp1b3b; sodium/potassium-transporting ATPase subunit beta-3b [KO:K01540]
137006127  slc8a1b; sodium/calcium exchanger 1b [KO:K05849]
137006149  actc1b; actin, alpha cardiac muscle 1b [KO:K12314]
137006207  cox7a2a; cytochrome c oxidase subunit 7A2a [KO:K02270]
137007165  ryr2b; ryanodine receptor 2 isoform X1 [KO:K04962]
137007441  zgc:163073; myosin light chain 4 isoform X1 [KO:K12750]
137007485  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
137007513  uqcrc2b; cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
137007601  cox7a2l; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
137008226  ryr2a; ryanodine receptor 2 [KO:K04962]
137008858  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
137008860  tnnc1a; troponin C type 1a (slow) [KO:K05865]
137008884  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
137008938  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
137009009  tnnc1b; troponin C type 1b (slow) [KO:K05865]
137009084  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a [KO:K01540]
137009344  cox4i2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
137010533  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
137010569  tnnt2b; troponin T, cardiac muscle isoforms [KO:K12045]
137010626  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
137010651  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
137010696  myl4; myosin light chain 4 [KO:K12750]
137010895  uqcrh; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
137010900  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
137010901  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a isoform X1 [KO:K04866]
137010951  cacng4a; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
137011087  cyc1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
137011130  [KO:K04867]
137011283  uqcrc1; cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
137011300  cox6c; cytochrome c oxidase subunit 6C [KO:K02268]
137011417  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
137011740  slc9a7; sodium/hydrogen exchanger 7 isoform X1 [KO:K12041]
137012047  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
137012294  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
137012430  slc8a4a; solute carrier family 8 member 4a isoform X1 [KO:K05849]
137012767  cox8a; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
137012994  cox7b; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
137013054  uqcr10; cytochrome b-c1 complex subunit 9 [KO:K00419]
137013322  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
137013330  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
137013439  [KO:K17751]
137013441  [KO:K17751]
137013442  [KO:K17751]
137013443  [KO:K17751]
137013444  [KO:K17751]
137013572  cox4i1l; cytochrome c oxidase subunit 4I1-like [KO:K02263]
137013661  [KO:K17751]
137013662  [KO:K17751]
137014028  cox6b1; cytochrome c oxidase subunit 6B1 [KO:K02267]
137014705  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
137014784  tnnt2d; troponin T2d, cardiac [KO:K12045]
137014979  cox8b; cytochrome c oxidase subunit 8B [KO:K02273]
137014988  cox5aa; cytochrome c oxidase subunit 5Aa [KO:K02264]
137015079  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
137015190  acte1; beta-actin-like protein 2 [KO:K12314]
137017468  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
137017500  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
137017573  cox6a2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
137017975  uqcrc2a; ubiquinol-cytochrome c reductase core protein 2a [KO:K00415]
137017999  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
137018392  si:dkey-85n7.8; COX8 domain-containing protein [KO:K02273]
137019011  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
137019143  trdn; triadin isoform X1 [KO:K23449]
137019219  cox7a2b; cytochrome c oxidase subunit 7A2b [KO:K02270]
137019266  myh6; myosin-6 [KO:K17751]
137019361  actc2; actin, alpha, cardiac muscle 2 [KO:K12314]
137019899  [KO:K02270]
137020165  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
137020322  cox5b2; cytochrome c oxidase subunit 5B2 [KO:K02265]
137020530  acta1b; actin alpha 1, skeletal muscle b [KO:K12314]
137020705  slc9a6a; sodium/hydrogen exchanger 6a [KO:K12041]
137020991  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
137021205  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
137021437  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
137021480  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
137021608  uqcrq; cytochrome b-c1 complex subunit 8 [KO:K00418]
137022627  cox4i1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
137022919  [KO:K04858]
137023270  [KO:K00411] [EC:7.1.1.8]
137023495  cox5ab; cytochrome c oxidase subunit 5Ab [KO:K02264]
137024287  tnnt2e; troponin T2e, cardiac isoform X1 [KO:K12045]
137024358  tnnt2c; troponin T2c, cardiac isoform X1 [KO:K12045]
137024487  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
137024507  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
137024601  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
137025686  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
137025702  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
137026229  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
137026362  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
137026591  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
137026672  cox5bb; cytochrome c oxidase subunit 5B1 [KO:K02265]
137026710  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
137026894  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
137027151  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
137027229  cox6a1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
137027389  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
137027681  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
137028262  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
137028947  tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
137029249  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
137029460  cox5ba; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
137029669  slc9a6b; sodium/hydrogen exchanger 6b [KO:K12041]
137029846  tpma; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
137030029  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
137030130  unm_hu7910; uncharacterized abhydrolase domain-containing protein DDB_G0269086 isoform X1 [KO:K00476] [EC:1.14.11.16]
137030335  uqcrfs1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
137031153  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
137031660  [KO:K01539] [EC:7.2.2.13]
137031687  [KO:K23445]
137031767  atp1a1a.4; sodium/potassium-transporting ATPase subunit alpha-1a.4 isoform X1 [KO:K01539] [EC:7.2.2.13]
137031822  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
137031883  cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
137032283  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b [KO:K01539] [EC:7.2.2.13]
137032538  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
137032560  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
137032672  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
137032928  [KO:K01539] [EC:7.2.2.13]
137032930  [KO:K01539] [EC:7.2.2.13]
137032994  acta1a; actin alpha 1, skeletal muscle a [KO:K12314]
137033588  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
137033712  myl2a; myosin regulatory light chain 2a [KO:K10351]
137033721  cmlc1; cardiac myosin light chain-1 [KO:K12750]
137034061  fxyd2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
137034444  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
137034570  cox7c; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
137034654  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
137035408  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
137035578  casq2; calsequestrin-2 [KO:K23445]
137035994  atp1a1b; sodium/potassium-transporting ATPase subunit alpha-1b isoform X1 [KO:K01539] [EC:7.2.2.13]
137037216  slc9a1b; sodium/hydrogen exchanger 1b isoform X1 [KO:K05742]
137037579  slc9a1a; sodium/hydrogen exchanger 1 [KO:K05742]
137037630  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
137037858  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
137037915  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a isoform X1 [KO:K04872]
137037954  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a isoform X1 [KO:K01539] [EC:7.2.2.13]
20160546  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
20160547  COX2; cytochrome c oxidase subunit II [KO:K02261]
20160550  COX3; cytochrome c oxidase subunit III [KO:K02262]
20160557  CYTB; cytochrome b [KO:K00412]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
cery04020  Calcium signaling pathway
KO pathway
ko04260   

DBGET integrated database retrieval system