KEGG   PATHWAY: cery04020
Entry
cery04020                   Pathway                                
Name
Calcium signaling pathway - Chanodichthys erythropterus (predatory carp)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
cery04020  Calcium signaling pathway
cery04020

Other DBs
GO: 0019722
Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002143  grin2da; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
137002339  mcoln3a; mucolipin-3 isoform X1 [KO:K04994]
137002384  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
137002428  agtr1a; type-1 angiotensin II receptor B [KO:K04166]
137002582  plcd1b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1 [KO:K05857] [EC:3.1.4.11]
137002583  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137002819  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
137002841  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
137002906  pde1cb; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
137002940  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
137003254  grin3ba; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
137003513  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
137003569  casq1a; calsequestrin-1a [KO:K23468]
137003636  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
137003728  htr5aa; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a isoform X1 [KO:K04161]
137003823  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
137003897  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
137004150  p2rx8; purinergic receptor P2X, ligand-gated ion channel, 8 [KO:K05219]
137004230  [KO:K04323]
137004231  [KO:K04323]
137004233  [KO:K04323]
137004281  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
137004318  grm5b; metabotropic glutamate receptor 5b isoform X1 [KO:K04604]
137004423  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
137004602  ighv4-2; immunoglobulin heavy variable 3-33 [KO:K06856]
137004626  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
137004700  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
137004937  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
137005142  drd1a; D(1) dopamine receptor [KO:K04144]
137005293  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
137005314  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
137005349  [KO:K22642]
137005469  [KO:K05218]
137005498  nos2b; nitric oxide synthase 2b, inducible [KO:K13241] [EC:1.14.13.39]
137006127  slc8a1b; sodium/calcium exchanger 1b [KO:K05849]
137006192  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137006304  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
137006311  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
137006405  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
137006451  grm1b; metabotropic glutamate receptor 1b [KO:K04603]
137006597  calm1a; calmodulin-1a [KO:K02183]
137006698  ptk2ba; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
137006730  bdkrb2; B2 bradykinin receptor [KO:K03916]
137006745  htr7a; 5-hydroxytryptamine receptor 7 [KO:K04163]
137006750  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
137006800  ptafr; platelet-activating factor receptor [KO:K04279]
137006817  [KO:K05840]
137006951  [KO:K05852]
137006957  [KO:K04963]
137007035  bdkrb1; B1 bradykinin receptor [KO:K03916]
137007131  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
137007133  plcb4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
137007165  ryr2b; ryanodine receptor 2 isoform X1 [KO:K04962]
137007326  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
137007330  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
137007341  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
137007485  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
137007574  [KO:K15040]
137007673  grin2cb; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
137007693  adrb1; beta-1 adrenergic receptor [KO:K04141]
137007778  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
137007793  chrm3b; muscarinic acetylcholine receptor M3 [KO:K04131]
137007813  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
137007945  drd6b; D(5)-like dopamine receptor [KO:K05840]
137008025  [KO:K04163]
137008085  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
137008121  ppifb; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
137008207  grin2ba; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
137008215  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
137008226  ryr2a; ryanodine receptor 2 [KO:K04962]
137008704  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
137008725  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
137008860  tnnc1a; troponin C type 1a (slow) [KO:K05865]
137008863  mcoln1b; mucolipin-1b [KO:K04992]
137008921  ednrab; endothelin receptor type Ab [KO:K04197]
137008928  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
137008942  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
137008954  tnnc2.2; troponin C, skeletal muscle [KO:K12042]
137009009  tnnc1b; troponin C type 1b (slow) [KO:K05865]
137009054  tnnc2.1; troponin C, skeletal muscle [KO:K12042]
137009211  camk1gb; calcium/calmodulin-dependent protein kinase IGb [KO:K08794] [EC:2.7.11.17]
137009258  mcoln3b; mucolipin-3 [KO:K04994]
137009449  fgf20b; fibroblast growth factor 20b [KO:K04358]
137009571  ngfa; neurotrophin-7 [KO:K02582]
137009720  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
137009732  ntsr1; neurotensin receptor type 1 [KO:K04211]
137009750  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
137009827  [KO:K04224]
137009927  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
137010730  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
137010733  oxtra; oxytocin receptor [KO:K04229]
137010777  mylkb; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
137010794  itpr1a; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 [KO:K04958]
137010816  htr2ab; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
137010878  oxtrb; oxytocin receptor b [KO:K04229]
137010948  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
137011012  mst1; hepatocyte growth factor-like protein [KO:K23441]
137011071  camk1a; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
137011201  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
137011258  tgfa; protransforming growth factor alpha [KO:K08774]
137011261  cysltr3; cysteinyl leukotriene receptor 2 [KO:K04322]
137011264  [KO:K17332]
137011379  mst1ra; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
137011433  fgf21; fibroblast growth factor 21 [KO:K22429]
137011506  ngfb; nerve growth factor [KO:K02582]
137011578  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
137011600  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
137011682  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
137011695  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
137012019  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
137012037  phkg1b; phosphorylase kinase, gamma 1b (muscle) [KO:K00871] [EC:2.7.11.19]
137012047  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
137012077  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
137012209  [KO:K03914]
137012328  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
137012332  p2rx4a; P2X purinoceptor 4a [KO:K05218]
137012430  slc8a4a; solute carrier family 8 member 4a isoform X1 [KO:K05849]
137012459  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
137012461  [KO:K04855]
137012518  adrb2b; adrenoceptor beta 2, surface b [KO:K04142]
137012602  adora2ab; adenosine A2a receptor b [KO:K04266]
137012665  stim1b; stromal interaction molecule 1b isoform X1 [KO:K16059]
137012710  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
137012730  fgf10a; fibroblast growth factor 10a [KO:K04358]
137012750  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
137012773  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
137012782  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
137012868  [KO:K03914]
137012880  drd1b; dopamine receptor D1b [KO:K04144]
137012913  fgf1b; fibroblast growth factor 1b [KO:K18496]
137013112  cysltr2a; cysteinyl leukotriene receptor 2 [KO:K04323]
137013119  [KO:K03914]
137013228  ptger1b; prostaglandin E receptor 1b (subtype EP1) [KO:K04258]
137013232  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
137013462  [KO:K04361] [EC:2.7.10.1]
137013529  pde1ca; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
137013778  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
137013838  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
137014163  [KO:K04633]
137014288  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
137014315  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
137014328  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
137014337  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
137014472  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
137014500  atp2b1b; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
137014771  camk1db; calcium/calmodulin-dependent protein kinase 1Db isoform X1 [KO:K08794] [EC:2.7.11.17]
137014777  [KO:K04149]
137014948  [KO:K04809]
137014996  ntrk3a; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
137015018  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
137015080  [KO:K04358]
137015095  chrm2b; muscarinic acetylcholine receptor M2 [KO:K04130]
137015259  egf; pro-epidermal growth factor [KO:K04357]
137015501  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
137015576  calml4b; calmodulin-like protein 4 [KO:K02183]
137017195  [KO:K04718] [EC:2.7.1.91]
137017251  [KO:K08049] [EC:4.6.1.1]
137017306  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
137017385  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
137017500  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
137017535  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
137017579  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
137017672  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
137017725  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
137017749  [KO:K05857] [EC:3.1.4.11]
137017758  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
137017882  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
137017961  fgf16; fibroblast growth factor 16 [KO:K04358]
137018000  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
137018068  p2rx3a; P2X purinoceptor 3a [KO:K05217]
137018419  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
137018433  fgf24; fibroblast growth factor 24 [KO:K04358]
137018500  itpkb; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
137018534  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137018558  fgf18a; fibroblast growth factor 18a [KO:K04358]
137018599  [KO:K08043] [EC:4.6.1.1]
137018614  hrh2a; histamine receptor H2a [KO:K04150]
137018724  si:dkey-63b1.1; B2 bradykinin receptor [KO:K03916]
137018759  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
137018848  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
137018882  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
137018885  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
137018973  mylk4b; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
137019007  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
137019036  grm1a; metabotropic glutamate receptor 1 [KO:K04603]
137019093  drd5a; D(1B) dopamine receptor [KO:K05840]
137019143  trdn; triadin isoform X1 [KO:K23449]
137019160  pln1; cardiac phospholamban [KO:K05852]
137019172  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
137019188  chrm1a; muscarinic acetylcholine receptor M1 [KO:K04129]
137019294  plcb4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
137019295  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
137019364  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
137019367  calm1b; calmodulin-1b [KO:K02183]
137020078  fgf8a; fibroblast growth factor 8 [KO:K04358]
137020165  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
137020284  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
137020294  lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
137020362  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
137020398  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
137020496  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
137020514  tacr2; substance-K receptor [KO:K04223]
137020566  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
137020625  ppifa; peptidylprolyl isomerase Fa [KO:K09565] [EC:5.2.1.8]
137020746  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
137020759  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
137020809  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
137020876  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
137021018  slc25a5; ADP/ATP translocase 2 [KO:K05863]
137021037  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
137021040  grpr; gastrin-releasing peptide receptor [KO:K04169]
137021147  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
137021155  grin3bb; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
137021168  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
137021302  hrh1; histamine H1 receptor [KO:K04149]
137021360  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
137021437  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
137021452  itpr1b; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
137021456  mst1rb; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
137021471  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
137021480  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
137021495  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
137021568  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
137021575  tfeb; transcription factor EB isoform X1 [KO:K15590]
137021706  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
137021723  adra1bb; adrenoceptor alpha 1Bb [KO:K04136]
137021738  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
137021806  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
137021855  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
137022798  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
137022991  fgf7; fibroblast growth factor 7 [KO:K04358]
137023247  hgfb; hepatocyte growth factor [KO:K05460]
137023276  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
137023308  itpr2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
137023454  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
137023459  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
137023504  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
137023776  fgf6b; fibroblast growth factor 6b isoform X1 [KO:K04358]
137023777  fgf23; fibroblast growth factor 23 [KO:K22428]
137023807  avpr1ab; arginine vasopressin receptor 1Ab [KO:K04226]
137023946  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
137024157  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
137024274  camk1da; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
137024303  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
137024415  atp2b1a; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
137024507  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
137024677  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
137025670  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
137026279  atp2b3a; plasma membrane calcium-transporting ATPase 3a isoform X1 [KO:K05850] [EC:7.2.2.10]
137026289  [KO:K04852]
137026362  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
137026402  p2rx7; P2X purinoceptor 7 [KO:K05220]
137026403  p2rx4b; P2X purinoceptor 4b [KO:K05218]
137026483  [KO:K04211]
137026497  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
137026591  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
137026685  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
137026710  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
137026794  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
137026821  adra1aa; adrenoceptor alpha 1Aa isoform X1 [KO:K04135]
137026894  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
137027010  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
137027080  adora2aa; adenosine A2a receptor a [KO:K04266]
137027151  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
137027198  fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
137027234  orai1a; calcium release-activated calcium channel protein 1 [KO:K16056]
137027270  adrb3a; adrenoceptor beta 3a [KO:K04143]
137027327  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
137027346  [KO:K04362] [EC:2.7.10.1]
137027359  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
137027419  [KO:K04282]
137027529  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
137027608  htr2b; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
137027740  fgf22; fibroblast growth factor 22 [KO:K04358]
137027768  gna11a; guanine nucleotide-binding protein subunit alpha-11a isoform X1 [KO:K04634]
137027770  [KO:K04637]
137027805  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
137027823  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
137028076  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
137028091  [KO:K04297]
137028123  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
137028262  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
137028267  camk1ga; calcium/calmodulin-dependent protein kinase IGa [KO:K08794] [EC:2.7.11.17]
137028371  hrh2b; histamine receptor H2b [KO:K04150]
137028385  fgf18b; fibroblast growth factor 18b [KO:K04358]
137028389  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
137028496  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
137028537  [KO:K04515] [EC:2.7.11.17]
137028555  tacr1b; tachykinin receptor 1b [KO:K04222]
137028576  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
137028583  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
137028594  adrb3b; adrenoceptor beta 3b [KO:K04143]
137028681  ryr1a; ryanodine receptor 1 isoform X1 [KO:K04961]
137028748  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
137028810  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
137028811  [KO:K04163]
137029039  pdgfba; platelet-derived growth factor beta polypeptide a [KO:K17386]
137029057  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
137029197  [KO:K05212]
137029200  pdgfaa; platelet-derived growth factor alpha polypeptide a isoform X1 [KO:K04359]
137029348  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
137029419  [KO:K04266]
137029986  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
137030003  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
137030080  tpcn2; two pore channel protein 2 [KO:K14077]
137030130  unm_hu7910; uncharacterized abhydrolase domain-containing protein DDB_G0269086 isoform X1 [KO:K00476] [EC:1.14.11.16]
137030139  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
137030170  ntrk3b; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
137030223  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
137030288  cckar; cholecystokinin receptor type A [KO:K04194]
137030293  stim2b; stromal interaction molecule 2 [KO:K18196]
137030589  ltb4r2a; leukotriene B4 receptor 2a [KO:K04297]
137030819  casq1b; calsequestrin-1b isoform X1 [KO:K23468]
137030911  chrna7a; neuronal acetylcholine receptor subunit alpha-7a [KO:K04809]
137030917  fgf3; fibroblast growth factor 3 [KO:K04358]
137030918  fgf4; fibroblast growth factor 4 [KO:K04358]
137030919  fgf19; fibroblast growth factor 19 [KO:K22603]
137031140  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
137031141  [KO:K04348] [EC:3.1.3.16]
137031153  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
137031154  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
137031189  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
137031257  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
137031262  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
137031340  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
137031362  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
137031374  calml4a; calmodulin-like protein 4a [KO:K02183]
137031449  erbb4a; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
137031570  ednraa; endothelin receptor type Aa [KO:K04197]
137031687  [KO:K23445]
137031842  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
137031887  slc25a4; ADP/ATP translocase 1 [KO:K05863]
137032022  mcoln1a; mucolipin-1a isoform X1 [KO:K04992]
137032078  p2rx3b; P2X purinoceptor 3b isoform X1 [KO:K05217]
137032113  chrna8; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
137032126  ednrba; endothelin receptor Ba [KO:K04198]
137032141  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
137032149  grin2ab; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
137032154  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
137032235  tacr3a; tachykinin receptor 3a [KO:K04224]
137032252  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
137032260  fgf8b; fibroblast growth factor 8b [KO:K04358]
137032355  [KO:K04160]
137032543  stim2a; stromal interaction molecule 2 isoform X1 [KO:K18196]
137032560  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
137032676  [KO:K05840]
137032708  cckbra; cholecystokinin receptor-like [KO:K04194]
137032740  fgf20a; fibroblast growth factor 20a [KO:K04358]
137032894  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [KO:K05210]
137032899  adra1d; alpha-1A adrenergic receptor [KO:K04137]
137032937  [KO:K05085] [EC:2.7.10.1]
137032991  tacr3l; tachykinin receptor 3-like [KO:K04224]
137033110  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
137033538  p2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
137033562  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
137033588  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
137033618  tacr1a; tachykinin receptor 1a [KO:K04222]
137033643  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
137033675  tpcn1; two pore channel protein 1 isoform X1 [KO:K16896]
137033796  gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
137033820  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
137033825  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
137033858  chrm1b; muscarinic acetylcholine receptor M1 [KO:K04129]
137033885  nos2a; nitric oxide synthase 2a, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
137034136  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
137034159  drd7; dopamine receptor D7 [KO:K05840]
137034241  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
137034268  camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
137034451  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
137034543  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
137034607  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
137034616  p2rx2; P2X purinoceptor 2 [KO:K05216]
137034654  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
137034673  f2r; proteinase-activated receptor 1 [KO:K03914]
137034682  fgf10b; fibroblast growth factor 10b [KO:K04358]
137034755  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
137034764  adora2b; adenosine receptor A2b [KO:K04267]
137034884  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
137034914  orai2; protein orai-2 [KO:K16057]
137035007  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
137035063  fgf5; fibroblast growth factor 5 [KO:K04358]
137035332  [KO:K05085] [EC:2.7.10.1]
137035460  ednrbb; endothelin receptor type B isoform X1 [KO:K04198]
137035484  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
137035506  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
137035578  casq2; calsequestrin-2 [KO:K23445]
137035801  fgf9; fibroblast growth factor 4A isoform X1 [KO:K04358]
137035849  slc25a6; ADP/ATP translocase 3 [KO:K05863]
137035850  pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
137035888  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
137036051  cckbrb; cholecystokinin receptor [KO:K04194]
137036113  htr2aa; 5-hydroxytryptamine receptor 2A [KO:K04157]
137037257  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
137037709  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
137037717  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
137037809  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
cery04010  MAPK signaling pathway
cery04070  Phosphatidylinositol signaling system
cery04210  Apoptosis
KO pathway
ko04020   

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