KEGG   PATHWAY: cfa00564
Entry
cfa00564                    Pathway                                
Name
Glycerophospholipid metabolism - Canis lupus familiaris (dog)
Class
Metabolism; Lipid metabolism
Pathway map
cfa00564  Glycerophospholipid metabolism
cfa00564

Module
cfa_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:cfa00564]
cfa_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:cfa00564]
cfa_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:cfa00564]
Other DBs
GO: 0006650
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
100302747  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
100683790  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
100684122  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X3 [KO:K19007] [EC:2.3.1.51]
100686158  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
100687022  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100855579  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
100855691  DGKA; diacylglycerol kinase alpha isoform X3 [KO:K00901] [EC:2.7.1.107]
100856013  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
100856443  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
102151235  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
403403  PLA2G15; phospholipase A2 group XV precursor [KO:K06129] [EC:3.1.1.5]
404011  PLA2G1B; phospholipase A2 preproprotein [KO:K01047] [EC:3.1.1.4]
474857  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
475585  PLPP5; phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
475658  MBOAT2; lysophospholipid acyltransferase 2 isoform X2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
475670  LPIN1; phosphatidate phosphatase LPIN1 isoform X4 [KO:K15728] [EC:3.1.3.4]
475920  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
476002  CHKA; choline kinase alpha isoform X5 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
476045  PLAAT3; phospholipase A and acyltransferase 3 isoform X3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
476932  DGKH; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
477544  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2 [KO:K01613] [EC:4.1.1.65]
477582  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
477846  PLPP4; phospholipid phosphatase 4 isoform X3 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
478207  PLA2G5; phospholipase A2 group V isoform X5 [KO:K01047] [EC:3.1.1.4]
478238  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
478460  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
478505  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
478511  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
478514  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
478600  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
478755  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X2 [KO:K00111] [EC:1.1.5.3]
478935  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
479204  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X2 [KO:K00649] [EC:2.3.1.42]
479473  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
479504  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
479526  PEMT; phosphatidylethanolamine N-methyltransferase isoform X3 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
479557  PLPP3; phospholipid phosphatase 3 isoform X2 [KO:K01080] [EC:3.1.3.4]
479680  LCAT; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
480048  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
480663  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
481256  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
482328  DGKB; diacylglycerol kinase beta isoform X2 [KO:K00901] [EC:2.7.1.107]
482709  DGKI; LOW QUALITY PROTEIN: diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
483023  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
483401  PTDSS2; phosphatidylserine synthase 2 isoform X2 [KO:K08730] [EC:2.7.8.29]
483635  DGKZ; diacylglycerol kinase zeta isoform X4 [KO:K00901] [EC:2.7.1.107]
484502  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
484993  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X4 [KO:K14676] [EC:3.1.1.5]
485626  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein isoform X2 [KO:K00006] [EC:1.1.1.8]
485778  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
485780  CDS2; phosphatidate cytidylyltransferase 2 isoform X1 [KO:K00981] [EC:2.7.7.41]
485876  LPIN3; phosphatidate phosphatase LPIN3 isoform X3 [KO:K15728] [EC:3.1.3.4]
486167  DGKD; diacylglycerol kinase delta isoform X3 [KO:K00901] [EC:2.7.1.107]
486361  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
486637  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
486715  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
486775  CHAT; LOW QUALITY PROTEIN: choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
486890  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [KO:K00629] [EC:2.3.1.15]
487397  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
487398  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
487399  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
487512  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
487514  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
487515  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
487840  CDS1; phosphatidate cytidylyltransferase 1 isoform X2 [KO:K00981] [EC:2.7.7.41]
488066  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
488115  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
488167  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
488238  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
488867  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
489045  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
489056  SAMD8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
489828  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
489940  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
489997  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
491069  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
491102  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
491249  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2 [KO:K13509] [EC:2.3.1.51]
491884  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
606800  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
607530  CRLS1; cardiolipin synthase (CMP-forming) isoform X2 [KO:K08744] [EC:2.7.8.41]
607608  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
607640  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
607942  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X2 [KO:K00006] [EC:1.1.1.8]
607962  PLPP1; phospholipid phosphatase 1 isoform X3 [KO:K01080] [EC:3.1.3.4]
608811  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
609018  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
609933  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [KO:K13514] [EC:2.3.1.-]
610214  CHPT1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
611194  PLB1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
611330  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
612306  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
612697  PLD4; 5'-3' exonuclease PLD4 isoform X1 [KO:K16860] [EC:3.1.4.4]
612948  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
cfa00010  Glycolysis / Gluconeogenesis
cfa00260  Glycine, serine and threonine metabolism
cfa00561  Glycerolipid metabolism
cfa00562  Inositol phosphate metabolism
cfa00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
cfa00565  Ether lipid metabolism
cfa00620  Pyruvate metabolism
KO pathway
ko00564   

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