KEGG   PATHWAY: cvf04150
Entry
cvf04150                    Pathway                                
Name
mTOR signaling pathway - Charadrius vociferus (killdeer)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cvf04150  mTOR signaling pathway
cvf04150

Organism
Charadrius vociferus (killdeer) [GN:cvf]
Gene
104281603  WNT5B; protein Wnt-5b [KO:K00444]
104281609  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104281647  KRAS; GTPase KRas isoform X1 [KO:K07827]
104281676  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
104281683  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
104281689  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
104281817  RRAGC; ras-related GTP-binding protein C [KO:K16186]
104281838  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104281881  [KO:K03158]
104281889  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
104282104  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
104282214  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
104282412  WNT3A; protein Wnt-3a [KO:K00312]
104282413  WNT9A; protein Wnt-9a [KO:K01064]
104282648  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104282652  CAB39; calcium-binding protein 39 [KO:K08272]
104282773  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104282805  WNT5A; protein Wnt-5a [KO:K00444]
104282900  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
104282958  [KO:K16185]
104282962  RHOA; transforming protein RhoA [KO:K04513]
104283047  FZD4; frizzled-4 [KO:K02354]
104283204  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104283369  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104283507  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104283555  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104283558  [KO:K01384]
104283706  NPRL3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
104283931  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104284088  CAB39L; calcium-binding protein 39-like [KO:K08272]
104284130  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
104284358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104284375  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
104284526  SEC13; protein SEC13 homolog [KO:K14004]
104284679  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104284782  WDR59; WD repeat-containing protein 59 [KO:K20409]
104284816  WNT1; proto-oncogene Wnt-1 [KO:K03209]
104284940  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
104285004  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
104285082  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104285124  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104285155  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104285229  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
104285267  WNT16; protein Wnt-16 [KO:K01558]
104285339  WNT6; protein Wnt-6 [KO:K00445]
104285342  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
104285383  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
104285480  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
104285531  WNT10A; protein Wnt-10a [KO:K01357]
104285551  WNT11; protein Wnt-11 [KO:K01384]
104285627  ATP6V1B1; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, kidney isoform [KO:K02147]
104285697  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
104285739  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104285844  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104285851  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104286230  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104286266  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104286352  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104286567  GATSL2; GATS-like protein 2 [KO:K23081]
104286890  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104287161  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104287484  [KO:K02432]
104287659  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
104287885  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
104288079  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
104288303  WNT2; LOW QUALITY PROTEIN: protein Wnt-2 [KO:K00182]
104288536  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104288573  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104288591  IGF1; insulin-like growth factor I [KO:K05459]
104288666  RRAGD; ras-related GTP-binding protein D [KO:K16186]
104288725  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104288901  RHEB; GTP-binding protein Rheb [KO:K07208]
104289144  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104289185  FZD10; frizzled-10 [KO:K02842]
104289221  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
104289233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104289484  WNT2B; protein Wnt-2b [KO:K00182]
104289524  NRAS; GTPase NRas [KO:K07828]
104289608  DEPDC5; DEP domain-containing protein 5 isoform X1 [KO:K20404]
104289740  WNT8B; protein Wnt-8b [KO:K00714]
104289848  FZD9; frizzled-9 [KO:K02842]
104290037  SEH1L; nucleoporin SEH1 [KO:K14299]
104290120  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104290135  FLCN; folliculin [KO:K09594]
104290283  HRAS; GTPase HRas [KO:K02833]
104290289  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
104290423  [KO:K02649]
104290455  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104290469  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104290488  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
104290643  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
104290652  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
104290696  WNT4; protein Wnt-4 [KO:K00408]
104290765  WNT7A; protein Wnt-7a [KO:K00572]
104290771  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104290866  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104290993  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
104290997  FZD7; frizzled-7 [KO:K02432]
104291046  FZD5; frizzled-5 [KO:K02375]
104291056  IRS1; insulin receptor substrate 1 [KO:K16172]
104291366  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
104291562  FNIP1; folliculin-interacting protein 1 [KO:K20400]
104291630  [KO:K08267]
104291848  WNT8A; protein Wnt-8a [KO:K00714]
104291986  NPRL2; nitrogen permease regulator 2-like protein [KO:K20405]
104292122  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104292183  RPS6; 40S ribosomal protein S6 [KO:K02991]
104292203  WDR24; WD repeat-containing protein 24 [KO:K20408]
104292322  [KO:K20394]
104292379  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
104292424  FZD6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
104292425  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104292587  INS; insulin [KO:K04526]
104292814  TSC1; hamartin isoform X1 [KO:K07206]
104292860  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
104292976  WNT3; proto-oncogene Wnt-3 [KO:K00312]
104292981  WNT9B; protein Wnt-9b [KO:K01064]
104293055  SOS1; son of sevenless homolog 1 [KO:K03099]
104293459  FZD2; frizzled-2 [KO:K02235]
104293471  [KO:K00408]
104293851  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
104293896  [KO:K20402]
104294062  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
104294083  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104294145  FNIP2; folliculin-interacting protein 2 [KO:K20401]
104294337  SOS2; son of sevenless homolog 2 [KO:K03099]
104294509  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
104294581  SLC38A9; putative sodium-coupled neutral amino acid transporter 9 [KO:K14995]
104294781  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104294976  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
104294985  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
104294989  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
104295005  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104295097  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104295102  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104295296  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104295366  FZD8; frizzled-8 [KO:K02375]
104295377  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104295401  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104295405  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
104295548  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104295570  MIOS; LOW QUALITY PROTEIN: WD repeat-containing protein mio [KO:K20407]
104295671  FZD3; frizzled-3 [KO:K02329]
104295806  PRR5L; proline-rich protein 5-like [KO:K20411]
104295962  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
104296049  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cvf00561  Glycerolipid metabolism
cvf04010  MAPK signaling pathway
cvf04140  Autophagy - animal
cvf04810  Regulation of actin cytoskeleton
cvf04910  Insulin signaling pathway
KO pathway
ko04150   

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