KEGG   PATHWAY: cvf04810
Entry
cvf04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Charadrius vociferus (killdeer)
Class
Cellular Processes; Cell motility
Pathway map
cvf04810  Regulation of actin cytoskeleton
cvf04810

Other DBs
GO: 0030036
Organism
Charadrius vociferus (killdeer) [GN:cvf]
Gene
104281539  ITGB8; integrin beta-8 [KO:K06591]
104281647  KRAS; GTPase KRas isoform X1 [KO:K07827]
104281846  ITGB4; integrin beta-4 [KO:K06525]
104281909  [KO:K12757]
104281910  [KO:K12757]
104281939  MYH10; myosin-10 isoform X1 [KO:K10352]
104282148  SSH2; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104282173  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
104282200  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104282220  PPP1CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104282221  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104282232  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104282525  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
104282547  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104282571  MSN; moesin [KO:K05763]
104282618  FGF18; fibroblast growth factor 18 [KO:K04358]
104282648  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104282663  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
104282773  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104282881  FAM49B; protein FAM49B isoform X1 [KO:K27976]
104282962  RHOA; transforming protein RhoA [KO:K04513]
104283075  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104283115  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104283204  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104283294  [KO:K05730]
104283349  [KO:K04362] [EC:2.7.10.1]
104283434  BDKRB2; B2 bradykinin receptor [KO:K03916]
104283435  BDKRB1; B1 bradykinin receptor [KO:K03915]
104283485  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104283498  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
104283519  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
104283579  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
104283645  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104283660  MYH9; myosin-9 [KO:K10352]
104283668  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104283873  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
104283950  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
104283960  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
104284034  EZR; ezrin isoform X1 [KO:K08007]
104284264  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104284292  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
104284306  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
104285068  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
104285091  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
104285102  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104285124  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104285235  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
104285296  [KO:K00907] [EC:2.7.11.18]
104285374  ITGB3; integrin beta-3 [KO:K06493]
104285500  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104285682  [KO:K05745]
104285685  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
104285739  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104285752  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
104285786  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104285799  F2R; proteinase-activated receptor 1 [KO:K03914]
104286049  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
104286229  C8B; complement component C8 beta chain [KO:K03998]
104286266  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104286342  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
104286392  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104286419  ACTR2; actin-related protein 2 [KO:K17260]
104286450  FGF20; fibroblast growth factor 20 [KO:K04358]
104286519  MYL10; myosin regulatory light chain 10 [KO:K12756]
104286554  CRK; adapter molecule crk isoform X1 [KO:K04438]
104286656  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
104286687  PFN4; profilin-4 [KO:K05759]
104286707  FAM49A; protein FAM49A [KO:K27976]
104286759  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104286838  EGF; pro-epidermal growth factor [KO:K04357]
104286903  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104286976  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
104287339  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
104287426  FGF7; fibroblast growth factor 7 [KO:K04358]
104287451  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104287471  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
104287572  FGF3; fibroblast growth factor 3 [KO:K04358]
104287574  FGF4; fibroblast growth factor 4 [KO:K04358]
104287575  FGF19; fibroblast growth factor 19 [KO:K22603]
104287607  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
104287699  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104287837  MYH11; myosin-11 isoform X1 [KO:K10352]
104287891  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
104287977  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104288032  [KO:K00921] [EC:2.7.1.150]
104288043  ACTR3B; actin-related protein 3B [KO:K18584]
104288078  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
104288144  RDX; radixin [KO:K05762]
104288180  CFL2; cofilin-2 [KO:K05765]
104288285  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104288340  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
104288458  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
104288459  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104288472  MRAS; ras-related protein M-Ras [KO:K07831]
104288520  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104288536  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104288573  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104288739  FN1; fibronectin [KO:K05717]
104288749  NCKAP1; nck-associated protein 1 [KO:K05750]
104288841  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
104289001  FGF2; fibroblast growth factor 2 [KO:K18497]
104289154  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
104289233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104289254  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104289524  NRAS; GTPase NRas [KO:K07828]
104289616  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
104289650  PXN; paxillin [KO:K05760]
104289799  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104289828  VCL; vinculin [KO:K05700]
104289856  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
104289931  ITGA8; integrin alpha-8 [KO:K06584]
104290141  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
104290143  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104290146  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
104290223  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104290283  HRAS; GTPase HRas [KO:K02833]
104290309  PDGFD; platelet-derived growth factor D [KO:K05450]
104290342  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104290423  [KO:K02649]
104290469  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104290646  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
104290695  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104290761  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
104290771  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104291015  ABI2; abl interactor 2 [KO:K05751]
104291018  ITGAV; integrin alpha-V [KO:K06487]
104291104  C8G; complement component C8 gamma chain [KO:K03999]
104291377  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104291385  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
104291389  FGF9; fibroblast growth factor 9 [KO:K04358]
104291488  FGF16; fibroblast growth factor 16 [KO:K04358]
104291693  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104291753  [KO:K02085]
104291838  TMSB4X; thymosin beta-4 [KO:K05764]
104292068  ITGB2; integrin beta-2 [KO:K06464]
104292205  ITGA9; integrin alpha-9 [KO:K06585]
104292255  [KO:K06269] [EC:3.1.3.16]
104292259  NCKAP1L; nck-associated protein 1-like [KO:K05750]
104292587  INS; insulin [KO:K04526]
104292650  [KO:K26108]
104292656  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
104292671  ITGA11; integrin alpha-11 [KO:K06587]
104292719  ARHGEF7; rho guanine nucleotide exchange factor 7 [KO:K13710]
104292844  GSN; gelsolin [KO:K05768]
104292891  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
104292916  C5; complement C5 [KO:K03994]
104292931  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
104292994  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104293055  SOS1; son of sevenless homolog 1 [KO:K03099]
104293056  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
104293116  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104293258  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
104293289  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
104293456  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
104293613  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
104293690  CRKL; crk-like protein [KO:K04438]
104293989  MYLK2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
104294060  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
104294075  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
104294083  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104294114  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104294190  PDGFC; platelet-derived growth factor C [KO:K05450]
104294228  APC; LOW QUALITY PROTEIN: adenomatous polyposis coli protein [KO:K02085]
104294337  SOS2; son of sevenless homolog 2 [KO:K03099]
104294452  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
104294552  FGF6; fibroblast growth factor 6 [KO:K04358]
104294563  FGF23; fibroblast growth factor 23 [KO:K22428]
104294571  ITGA1; integrin alpha-1 [KO:K06480]
104294596  ITGA2; integrin alpha-2 [KO:K06481]
104294632  FGF8; fibroblast growth factor 8 [KO:K04358]
104294656  ENAH; protein enabled homolog isoform X1 [KO:K05746]
104294700  [KO:K05759]
104294717  [KO:K04358]
104294880  ITGA6; integrin alpha-6 [KO:K06485]
104294930  ITGB6; integrin beta-6 [KO:K06589]
104294970  C6; complement component C6 [KO:K03995]
104294971  C7; complement component C7 [KO:K03996]
104295006  C9; complement component C9 [KO:K04000]
104295068  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
104295182  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
104295220  SCIN; adseverin [KO:K05768]
104295369  ITGB1; integrin beta-1 [KO:K05719]
104295393  ARHGEF12; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532]
104295401  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104295530  KNG1; kininogen-1 [KO:K03898]
104295548  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104295858  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
104295864  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
104296010  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
104296042  ACTR3; actin-related protein 3 [KO:K18584]
104296044  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
cvf04010  MAPK signaling pathway
cvf04510  Focal adhesion
cvf04520  Adherens junction
KO pathway
ko04810   

DBGET integrated database retrieval system