KEGG   DISEASE: 結核
エントリ  
H00342                                                             
名称    
結核
  下位グループ
多剤耐性結核 [DS:H01472]
概要    
Tuberculosis is an infectious disease caused by strains of mycobacteria, mainly Mycobacterium tuberculosis, resulting in an estimated two million deaths each year worldwide, more than from any other single bacterial pathogen. Inhalation is the predominant pathway of infection, making pulmonary tuberculosis the most common form of tuberculosis. Tuberculosis may arise either from a recent infection with M. tuberculosis, or from the reactivation of dormant bacilli, years or decades after initial infection. Extrapulmonary tuberculosis mainly results from reactivation of a tuberculous focus after hematogenous dissemination or lymphogenous spread from a primary, usually pulmonary focus.
カテゴリ  
感染症
階層分類  
感染症疾患 [BR:jp08401]
 細菌感染症
  放線菌による感染症
   H00342  結核
ICD-11 による疾患分類 [BR:jp08403]
 01 感染症・寄生虫症
  マイコバクテリア症
   結核
    1B10  呼吸器系の結核
     H00342  結核
    1B11  神経系の結核
     H00342  結核
    1B12  その他の器官系や器官の結核
     H00342  結核
感染症法による感染症分類 [jp08406.html]
 H00342
感染症法における特定病原体等 [jp08416.html]
 H00342
パスウェイ 
hsa05152  結核
病因遺伝子 
IFNG (protection) [HSA:3458] [KO:K04687]
IFNGR1 (susceptibility/protection) [HSA:3459] [KO:K05132]
IFNGR2 [HSA:3460] [KO:K05133]
HLA-DRB1 (susceptibility) [HSA:3123] [KO:K06752]
HLA-DQB1 (susceptibility) [HSA:3119] [KO:K06752]
SLC11A1 (susceptibility) [HSA:6556] [KO:K12347]
VDR (susceptibility) [HSA:7421] [KO:K08539]
MBL2 (protection) [HSA:4153] [KO:K03991]
CCL2 (susceptibility) [HSA:6347] [KO:K14624]
CD209 (susceptibility) [HSA:30835] [KO:K06563]
CISH (susceptibility) [HSA:1154] [KO:K04701]
IRGM (protection) [HSA:345611] [KO:K14139]
SP110 (susceptibility) [HSA:3431] [KO:K24503]
TIRAP (protection) [HSA:114609] [KO:K05403]
TLR2 (susceptibility) [HSA:7097] [KO:K10159]
病原体   
Mycobacterium tuberculosis [GN:mtu mtc mtf mtb mtk mtg mti mte mtl mto mtd mtj mtuc mtue mtuh maf]
Mycobacterium canettii [GN:mce mcq mcv mcx mcz]
治療薬   
デキサメタゾン [DR:D00292]
レボフロキサシン水和物 [DR:D00588]
フドステイン [DR:D01845]
ヒドロコルチゾン [DR:D00088]
コルチゾン酢酸エステル [DR:D00973]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
柴胡桂枝湯エキス [DR:D06964]
ストレプトマイシン硫酸塩 [DR:D01350]
サイクロセリン [DR:D00877]
リファンピシン [DR:D00211]
エンビオマイシン硫酸塩 [DR:D03278]
カナマイシン硫酸塩 [DR:D03262]
リファブチン [DR:D00424]
パラアミノサリチル酸カルシウム水和物 [DR:D03368]
アルミノパラアミノサリチル酸カルシウム水和物 [DR:D01643]
イソニアジド [DR:D00346]
イソニアジドメタンスルホン酸ナトリウム水和物 [DR:D02002]
ピラジナミド [DR:D00144]
エチオナミド [DR:D00591]
エタンブトール塩酸塩 [DR:D00878]
乾燥BCGワクチン [DR:D06466]
リンク   
ICD-11: 1B10 1B11 1B12
ICD-10: A15 A16 A17 A18 A19
MeSH: D014376
MedlinePlus: 000077
OMIM: 607948
文献    
  著者
Moller M, Hoal EG
  タイトル
Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis.
  雑誌
Tuberculosis (Edinb) 90:71-83 (2010)
DOI:10.1016/j.tube.2010.02.002
文献    
  著者
De Backer AI, Mortele KJ, De Keulenaer BL, Parizel PM
  タイトル
Tuberculosis: epidemiology, manifestations, and the value of medical imaging in diagnosis.
  雑誌
JBR-BTR 89:243-50 (2006)
文献    
  著者
Lawn SD, Zumla AI
  タイトル
Tuberculosis.
  雑誌
Lancet 378:57-72 (2011)
DOI:10.1016/S0140-6736(10)62173-3
文献    
PMID:16690980 (IFNG IFNGR1 IFNGR2)
  著者
Cooke GS, Campbell SJ, Sillah J, Gustafson P, Bah B, Sirugo G, Bennett S, McAdam KP, Sow O, Lienhardt C, Hill AV
  タイトル
Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.
  雑誌
Am J Respir Crit Care Med 174:339-43 (2006)
DOI:10.1164/rccm.200601-088OC
文献    
PMID:24024195 (SLC11A1 VDR HLA-DRB1 HLA-DQB1)
  著者
Wu F, Zhang W, Zhang L, Wu J, Li C, Meng X, Wang X, He P, Zhang J
  タイトル
NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the Chinese Kazakh population: a case-control study.
  雑誌
Biomed Res Int 2013:484535 (2013)
DOI:10.1155/2013/484535
文献    
PMID:16103355 (SLC11A1)
  著者
Malik S, Abel L, Tooker H, Poon A, Simkin L, Girard M, Adams GJ, Starke JR, Smith KC, Graviss EA, Musser JM, Schurr E
  タイトル
Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease.
  雑誌
Proc Natl Acad Sci U S A 102:12183-8 (2005)
DOI:10.1073/pnas.0503368102
文献    
PMID:32847384 (VDR)
  著者
Maruthai K, Sankar S, Subramanian M
  タイトル
Methylation Status of VDR Gene and its Association with Vitamin D Status and VDR Gene Expression in Pediatric Tuberculosis Disease.
  雑誌
Immunol Invest 51:73-87 (2022)
DOI:10.1080/08820139.2020.1810702
文献    
PMID:33270011 (MBL2)
  著者
Taheri M, Karimloo R, Sarani H, Molashahi B, Naderi M, Bahari G, Hashemi M
  タイトル
Association Study of MBL2 Gene Polymorphisms and Risk of Tuberculosis in Southeast of Iran.
  雑誌
Prague Med Rep 121:236-243 (2020)
DOI:10.14712/23362936.2020.20
文献    
PMID:20041183 (CCL2)
  著者
Hasan Z, Cliff JM, Dockrell HM, Jamil B, Irfan M, Ashraf M, Hussain R
  タイトル
CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis.
  雑誌
PLoS One 4:e8459 (2009)
DOI:10.1371/journal.pone.0008459
文献    
PMID:16379498 (CD209)
  著者
Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H, McElreavey K, Helden PD, Hoal EG, Gicquel B, Quintana-Murci L
  タイトル
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
  雑誌
PLoS Med 3:e20 (2006)
DOI:10.1371/journal.pmed.0030020
文献    
PMID:28954234 (CISH)
  著者
Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosere N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P
  タイトル
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
  雑誌
Cell Rep 20:3188-3198 (2017)
DOI:10.1016/j.celrep.2017.08.101
文献    
PMID:19750224 (IRGM)
  著者
Intemann CD, Thye T, Niemann S, Browne EN, Amanua Chinbuah M, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Helm S, Rusch-Gerdes S, Horstmann RD, Meyer CG
  タイトル
Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
  雑誌
PLoS Pathog 5:e1000577 (2009)
DOI:10.1371/journal.ppat.1000577
文献    
PMID:17149599 (SP110)
  著者
Szeszko JS, Healy B, Stevens H, Balabanova Y, Drobniewski F, Todd JA, Nejentsev S
  タイトル
Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis.
  雑誌
Hum Genet 121:155-60 (2007)
DOI:10.1007/s00439-006-0293-z
文献    
PMID:18305471 (TIRAP)
  著者
Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff TH, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD
  タイトル
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
  雑誌
Nat Genet 40:261-2; author reply 262-3 (2008)
DOI:10.1038/ng0308-261
文献    
PMID:14979495 (TLR2)
  著者
Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O
  タイトル
The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease.
  雑誌
Eur Respir J 23:219-23 (2004)
DOI:10.1183/09031936.03.00061703
LinkDB    

» English version

DBGET integrated database retrieval system