KEGG   PATHWAY: eai04142
Entry
eai04142                    Pathway                                
Name
Lysosome - Equus asinus (ass)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
eai04142  Lysosome
eai04142

Other DBs
GO: 0005764
Organism
Equus asinus (ass) [GN:eai]
Gene
106821926  CLTB; clathrin light chain B isoform X1 [KO:K04645]
106822301  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
106822427  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
106822436  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
106822582  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
106823092  GLA; alpha-galactosidase A isoform X1 [KO:K01189] [EC:3.2.1.22]
106823113  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
106823135  SLC17A5; sialin isoform X1 [KO:K12301]
106823465  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
106824010  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
106824017  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
106824018  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
106824102  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
106824146  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
106824381  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
106824845  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
106825078  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
106825364  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
106825422  IDUA; alpha-L-iduronidase isoform X2 [KO:K01217] [EC:3.2.1.76]
106825663  CTNS; cystinosin [KO:K12386]
106825972  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
106826331  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
106826451  NAGLU; LOW QUALITY PROTEIN: alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
106826513  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
106826656  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
106826849  CLTA; clathrin light chain A isoform X1 [KO:K04644]
106826861  GM2A; LOW QUALITY PROTEIN: ganglioside GM2 activator [KO:K12383]
106826920  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
106827262  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
106827375  SORT1; sortilin isoform X1 [KO:K12388]
106827418  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
106827629  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
106827716  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
106827740  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
106828084  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
106828200  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
106828247  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
106828495  GBA; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
106828573  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
106828635  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
106828956  AP3M2; AP-3 complex subunit mu-2 isoform X2 [KO:K12398]
106828971  HGSNAT; LOW QUALITY PROTEIN: heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
106829076  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
106829587  ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144]
106829760  CD164; sialomucin core protein 24 [KO:K06546]
106829838  [KO:K01197] [EC:3.2.1.35]
106829839  [KO:K01197] [EC:3.2.1.35]
106829848  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
106829872  [KO:K01197] [EC:3.2.1.35]
106829888  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
106830281  GGA3; LOW QUALITY PROTEIN: ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
106830629  [KO:K12382]
106830704  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
106830729  [KO:K01197] [EC:3.2.1.35]
106830730  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
106830901  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
106831016  [KO:K01074] [EC:3.1.2.22]
106831471  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
106831857  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
106831920  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X4 [KO:K01052] [EC:3.1.1.13]
106832031  [KO:K12399]
106832065  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
106832468  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
106833025  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
106833037  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
106833524  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
106833555  CTSW; cathepsin W isoform X2 [KO:K08569] [EC:3.4.22.-]
106834003  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
106834165  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
106834294  GALC; galactocerebrosidase isoform X3 [KO:K01202] [EC:3.2.1.46]
106834543  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
106834995  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
106835221  SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398]
106835355  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
106835448  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
106835581  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
106836201  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
106836253  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
106836254  [KO:K02155]
106836641  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
106836749  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
106836785  LITAFD; lITAF domain-containing protein isoform X1 [KO:K19363]
106837240  FUCA2; LOW QUALITY PROTEIN: plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
106837429  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
106837594  GGA1; LOW QUALITY PROTEIN: ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
106838003  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
106838179  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
106838188  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
106838288  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
106838367  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
106838448  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
106839299  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
106839972  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
106840071  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
106840631  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
106840814  CTSH; pro-cathepsin H isoform X1 [KO:K01366] [EC:3.4.22.16]
106841141  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
106841176  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
106841310  CD63; CD63 antigen [KO:K06497]
106841393  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
106841572  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
106841999  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
106842007  IGF2R; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564]
106842224  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
106842321  ABCB9; ABC-type oligopeptide transporter ABCB9 isoform X1 [KO:K05656]
106842534  IDS; LOW QUALITY PROTEIN: iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
106842640  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
106843038  CTSA; lysosomal protective protein isoform X2 [KO:K13289] [EC:3.4.16.5]
106843086  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
106843548  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
106844008  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
106844210  CD68; macrosialin [KO:K06501]
106844252  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
106844341  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
106844429  [KO:K01365] [EC:3.4.22.15]
106844519  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
106845500  ABCA2; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 2 [KO:K05642]
106845535  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
106845569  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
106845642  CLN3; battenin isoform X3 [KO:K12389]
106846025  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
106846148  GGA2; LOW QUALITY PROTEIN: ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
106846533  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
106846535  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
106846594  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
106846621  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
106846746  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
106846858  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
106847913  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
106848193  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
106848234  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
106848461  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
106848492  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
106848617  [KO:K01319] [EC:3.4.21.20]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
eai00511  Other glycan degradation
eai00531  Glycosaminoglycan degradation
eai04130  SNARE interactions in vesicular transport
eai04140  Autophagy - animal
eai04144  Endocytosis
KO pathway
ko04142   

DBGET integrated database retrieval system