KEGG   PATHWAY: ebe00230
Entry
ebe00230                    Pathway                                
Name
Purine metabolism - Escherichia coli BL21(DE3)
Class
Metabolism; Nucleotide metabolism
Pathway map
ebe00230  Purine metabolism
ebe00230

Module
ebe_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ebe00230]
ebe_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ebe00230]
ebe_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ebe00230]
ebe_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ebe00230]
ebe_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ebe00230]
ebe_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ebe00230]
ebe_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ebe00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli BL21(DE3) [GN:ebe]
Gene
B21_02856  nudF; ADP-sugar pyrophosphatase, subunit of ADP-sugar pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
B21_03201  nudE; ADP-sugar pyrophosphorylase [KO:K08312] [EC:3.6.1.-]
B21_03184  yhfW; predicted mutase [KO:K01839] [EC:5.4.2.7]
B21_04225  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
B21_00636  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
B21_01192  prs; ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
B21_02197  purF; amidophosphoribosyl transferase [KO:K00764] [EC:2.4.2.14]
B21_03835  purD; phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
B21_02354  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
B21_01808  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
B21_02413  purL; phosphoribosylformylglycinamide synthetase [KO:K01952] [EC:6.3.5.3]
B21_02353  purM; phosphoribosylformylglycinamide cyclo-ligase [KO:K01933] [EC:6.3.3.1]
B21_00477  purK; N5-carboxyaminoimidazole ribonucleotide synthetase monomer, subunit of N5-carboxyaminoimidazole ribonucleotide synthetase [KO:K01589] [EC:6.3.4.18]
B21_00478  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
B21_02330  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
B21_01137  purB; adenylosuccinate lyase [multifunctional] [KO:K01756] [EC:4.3.2.2]
B21_03836  purH; IMP cyclohydrolase / AICAR transformylase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
B21_00425  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
B21_00436  ushA; UDP-sugar hydrolase / 5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
B21_02559  surE; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
B21_00623  nagD; ribonucleotide monophosphatase [KO:K02566] [EC:3.1.3.5]
B21_03203  yrfG; purine nucleotidase [KO:K20881] [EC:3.1.3.-]
B21_00433  gsk; inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
B21_04226  deoD; purine nucleoside phosphorylase deoD-type [KO:K03784] [EC:2.4.2.1]
B21_00342  yaiE; conserved protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
B21_02447  yfiH; conserved protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
B21_00123  hpt; hypoxanthine-guanine phosphoribosyltransferase, subunit of hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
B21_02362  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
B21_02372  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
B21_04235  yjjX; ITPase/XTPase, subunit of ITPase / XTPase [KO:K01529] [EC:3.6.1.73]
B21_02747  rdgB; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
B21_00236  gpt; xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
B21_02661  xdhA; xanthine dehydrogenase subunit with putative molybdenum cofactor-binding domain, subunit of xanthine dehydrogenase [KO:K00087] [EC:1.17.1.4]
B21_02662  xdhB; putative xanthine dehydrogenase subunit, FAD-binding domain, subunit of xanthine dehydrogenase [KO:K13479] [EC:1.17.1.4]
B21_02663  xdhC; putative xanthine dehydrogenase, Fe-S subunit, subunit of xanthine dehydrogenase [KO:K13480]
B21_00246  yagR; aldehyde ferredoxin oxidoreductase: molybdenum cofactor-binding subunit, subunit of aldehyde ferredoxin oxidoreductase [KO:K11177] [EC:1.17.1.4]
B21_00247  yagS; aldehyde ferredoxin oxidoreductase, FAD-binding subunit, subunit of aldehyde ferredoxin oxidoreductase [KO:K11178] [EC:1.17.1.4]
B21_00248  yagT; aldehyde ferredoxin oxidoreductase, Fe-S subunit, subunit of aldehyde ferredoxin oxidoreductase [KO:K13483]
B21_02361  guaA; GMP synthetase [KO:K01951] [EC:6.3.5.2]
B21_00103  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
B21_02678  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
B21_03457  gmk; guanylate kinase / deoxyguanylate kinase [KO:K00942] [EC:2.7.4.8]
B21_02119  nrdA; nrdA, subunit of B1 protein and GDP reductase [multifunctional] [KO:K00525] [EC:1.17.4.1]
B21_02495  nrdE; nrdE, subunit of ribonucleoside-diphosphate reductase 2, alpha subunit dimer and ribonucleoside-diphosphate reductase 2 [KO:K00525] [EC:1.17.4.1]
B21_02120  nrdB; nrdB, subunit of B2 protein and GDP reductase [multifunctional] [KO:K00526] [EC:1.17.4.1]
B21_02496  nrdF; nrdF, subunit of ribonucleoside-diphosphate reductase 2, beta subunit dimer and ribonucleoside-diphosphate reductase 2 [KO:K00526] [EC:1.17.4.1]
B21_04070  nrdD; ribonucleoside-triphosphate reductase, subunit of anaerobic nucleoside-triphosphate reductase activating system [KO:K21636] [EC:1.1.98.6]
B21_00158  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
B21_02176  yfbR; dCMP phosphohydrolase [KO:K08722] [EC:3.1.3.89]
B21_03459  spoT; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [multifunctional] [KO:K01139] [EC:2.7.6.5 3.1.7.2]
B21_02356  ppx; exopolyphosphatase monomer, subunit of exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
B21_03606  gpp; guanosine-5'-triphosphate, 3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
B21_02591  relA; GTP pyrophosphokinase / GDP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
B21_03630  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
B21_04006  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
B21_01582  add; adenosine deaminase / deoxyadenosine deaminase [KO:K01488] [EC:3.5.4.4]
B21_01883  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
B21_02602  ygdH; conserved protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
B21_03491  ade; cryptic adenine deaminase monomer, subunit of cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
B21_04048  cpdB; 3'-nucleotidase / 2',3'-cyclic nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
B21_00430  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
B21_02588  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
B21_02854  cpdA; cAMP phosphodiesterase [KO:K03651] [EC:3.1.4.53]
B21_00052  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
B21_02565  cysC; adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
B21_02566  cysN; cysN, subunit of sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
B21_02567  cysD; cysD, subunit of sulfate adenylyltransferase [KO:K00957] [EC:2.7.7.4]
B21_01875  yedX; conserved protein, subunit of transthyretin-related protein [KO:K07127] [EC:3.5.2.17]
B21_00467  allB; allantoinase monomer, subunit of allantoinase [KO:K01466] [EC:3.5.2.5]
B21_00471  allC; allantoate amidohydrolase monomer, subunit of allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
B21_00470  ylbA; S-ureidoglycine aminohydrolase [KO:K14977] [EC:3.5.3.26]
B21_00460  allA; ureidoglycolate lyase [KO:K01483] [EC:4.3.2.3]
B21_00472  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
B21_00282  yahI; predicted carbamate kinase-like protein [KO:K00926] [EC:2.7.2.2]
B21_00476  ybcF; predicted carbamate kinase [KO:K00926] [EC:2.7.2.2]
B21_02669  yqeA; predicted amino acid kinase [KO:K00926] [EC:2.7.2.2]
B21_03661  ybl185; predicted carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ebe00030  Pentose phosphate pathway
ebe00220  Arginine biosynthesis
ebe00250  Alanine, aspartate and glutamate metabolism
ebe00260  Glycine, serine and threonine metabolism
ebe00340  Histidine metabolism
ebe00630  Glyoxylate and dicarboxylate metabolism
ebe00730  Thiamine metabolism
ebe00740  Riboflavin metabolism
ebe00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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