KEGG PATHWAY: ecj00260

PATHWAY: ecj00260

Entry

ecj00260                    Pathway

Name

Glycine, serine and threonine metabolism - Escherichia coli K-12 W3110

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ecj00260

Glycine, serine and threonine metabolism

Module

ecj_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ecj00260]

ecj_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:ecj00260]

ecj_M00555

Betaine biosynthesis, choline => betaine [PATH:ecj00260]

ecj_M00621

Glycine cleavage system [PATH:ecj00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Escherichia coli K-12 W3110 [GN:ecj]

Gene

JW0001

thrA; fused aspartokinase I and homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]

JW0002

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

JW0003

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

JW0112

lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]

JW0303

betA; choline dehydrogenase, a flavoprotein [KO:K00108] [EC:1.1.99.1]

JW0304

betB; betaine aldehyde dehydrogenase, NAD-dependent [KO:K00130] [EC:1.2.1.8]

JW0502

glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]

JW0738

gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]

JW0854

ltaE; L-allo-threonine aldolase, PLP-dependent [KO:K01620] [EC:4.1.2.48]

JW0890

serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]

JW1252

trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]

JW1253

trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]

JW1381

tynA; tyramine oxidase, copper-requiring [KO:K00276] [EC:1.4.3.21]

JW1532

ydfG; L-allo-threonine dehydrogenase, NAD(P)-binding [KO:K16066] [EC:1.1.1.381 1.1.1.-]

JW1803

sdaA; L-serine deaminase I [KO:K01752] [EC:4.3.1.17]

JW2363

dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]

JW2535

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

JW2569

pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]

JW2768

sdaB; L-serine deaminase II [KO:K01752] [EC:4.3.1.17]

JW2808

ygeA; predicted racemase [KO:K25316]

JW2871

gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]

JW2872

gcvH; glycine cleavage complex lipoylprotein [KO:K02437]

JW2873

gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]

JW2880

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

JW3088

tdcB; catabolic threonine dehydratase, PLP-dependent [KO:K01754] [EC:4.3.1.19]

JW3093

garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]

JW3396

asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding [KO:K00133] [EC:1.2.1.11]

JW3587

gpmI; phosphoglycero mutase III, cofactor-independent [KO:K15633] [EC:5.4.2.12]

JW3591

tdh; threonine 3-dehydrogenase, NAD(P)-binding [KO:K00060] [EC:1.1.1.103]

JW3592

kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]

JW3745

ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]

JW3911

metL; fused aspartokinase II and homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]

JW3984

lysC; aspartokinase III [KO:K00928] [EC:2.7.2.4]

JW4351

serB; 3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

JW4358

ytjC; phosphoglyceromutase 2, co-factor independent [KO:K15634] [EC:5.4.2.11]

JW5146

ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]

JW5520

tdcG; L-serine dehydratase 3 [KO:K01752] [EC:4.3.1.17]

JW5656

tiaE; 2-keto-D-gluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721