KEGG   PATHWAY: ecj00630
Entry
ecj00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli K-12 W3110
Class
Metabolism; Carbohydrate metabolism
Pathway map
ecj00630  Glyoxylate and dicarboxylate metabolism
ecj00630

Module
ecj_M00012  Glyoxylate cycle [PATH:ecj00630]
ecj_M00621  Glycine cleavage system [PATH:ecj00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli K-12 W3110 [GN:ecj]
Gene
JW0112  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
JW0114  acnB; bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
JW0324  prpC; 2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
JW0495  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
JW0496  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
JW0497  glxR; tartronate semialdehyde reductase, NADH-dependent [KO:K00042] [EC:1.1.1.60]
JW0502  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
JW0710  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
JW1220  purU; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
JW1268  acnA; aconitate hydratase 1 [KO:K27802]
JW1412  aldA; aldehyde dehydrogenase A, NAD-linked [KO:K07248] [EC:1.2.1.22 1.2.1.21]
JW1721  katE; hydroperoxidase HPII(III) [KO:K03781] [EC:1.11.1.6]
JW1789  yeaU; predicted dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
JW1839  eda; multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase, 2-keto-4-hydroxyglutarate aldolase, and oxaloacetate decarboxylase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
JW2218  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
JW2370  oxc; predicted oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
JW2371  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
JW2535  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
JW2770  fucO; L-1,2-propanediol oxidoreductase [KO:K00048] [EC:1.1.1.77]
JW2871  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
JW2872  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
JW2873  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
JW2884  yliK; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
JW2943  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
JW2946  glcD; glycolate oxidase subunit, FAD-linked [KO:K00104] [EC:1.1.99.14]
JW3033  ttdA; L-tartrate dehydratase, alpha subunit [KO:K03779] [EC:4.2.1.32]
JW3034  ttdB; L-tartrate dehydratase, beta subunit [KO:K03780] [EC:4.2.1.32]
JW3093  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
JW3205  mdh; malate dehydrogenase, NAD(P)-binding [KO:K00024] [EC:1.1.1.37]
JW3348  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
JW3841  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
JW3863  fdoI; formate dehydrogenase-O, cytochrome b556 subunit [KO:K00127]
JW3864  fdoH; formate dehydrogenase-O, Fe-S subunit [KO:K00124]
JW3865  fdoG; formate dehydrogenase-O, large subunit [KO:K00123] [EC:1.17.1.9]
JW3974  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
JW3975  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
JW4030  acs; bifunctional acetyl-CoA synthetase and propionyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
JW5146  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
JW5453  yqeF; predicted acyltransferase [KO:K00626] [EC:2.3.1.9]
JW5486  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
JW5487  glcE; glycolate oxidase FAD binding subunit [KO:K11472] [EC:1.1.99.14]
JW5526  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
JW5656  tiaE; 2-keto-D-gluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
ecj00010  Glycolysis / Gluconeogenesis
ecj00020  Citrate cycle (TCA cycle)
ecj00030  Pentose phosphate pathway
ecj00053  Ascorbate and aldarate metabolism
ecj00071  Fatty acid degradation
ecj00230  Purine metabolism
ecj00250  Alanine, aspartate and glutamate metabolism
ecj00260  Glycine, serine and threonine metabolism
ecj00270  Cysteine and methionine metabolism
ecj00620  Pyruvate metabolism
ecj00710  Carbon fixation by Calvin cycle
ecj00750  Vitamin B6 metabolism
ecj00910  Nitrogen metabolism
KO pathway
ko00630   

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