KEGG   PATHWAY: ecj00230
Entry
ecj00230                    Pathway                                
Name
Purine metabolism - Escherichia coli K-12 W3110
Class
Metabolism; Nucleotide metabolism
Pathway map
ecj00230  Purine metabolism
ecj00230

Module
ecj_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecj00230]
ecj_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecj00230]
ecj_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecj00230]
ecj_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecj00230]
ecj_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecj00230]
ecj_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecj00230]
ecj_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecj00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli K-12 W3110 [GN:ecj]
Gene
JW0048  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
JW0101  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
JW0156  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
JW0228  gpt; guanine-hypoxanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
JW0278  yagR; predicted oxidoreductase with molybdenum-binding domain [KO:K11177] [EC:1.17.1.4]
JW0279  yagS; predicted oxidoreductase with FAD-binding domain [KO:K11178] [EC:1.17.1.4]
JW0280  yagT; predicted xanthine dehydrogenase, 2Fe-2S subunit [KO:K13483]
JW0315  yahI; predicted carbamate kinase-like protein [KO:K00926] [EC:2.7.2.2]
JW0382  yaiE; conserved hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
JW0458  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
JW0463  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
JW0466  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
JW0469  ushA; bifunctional UDP-sugar hydrolase and 5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
JW0493  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
JW0500  allB; allantoinase [KO:K01466] [EC:3.5.2.5]
JW0503  ylbA; conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
JW0504  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
JW0505  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
JW0510  ybcF; predicted carbamate kinase [KO:K00926] [EC:2.7.2.2]
JW0511  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
JW0512  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
JW0661  nagD; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
JW0675  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
JW1117  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
JW1198  prsA; phosphoribosylpyrophosphate synthase [KO:K00948] [EC:2.7.6.1]
JW1615  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
JW1838  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
JW1953  yedX; conserved hypothetical protein [KO:K07127] [EC:3.5.2.17]
JW1963  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
JW2228  nrdA; ribonucleoside diphosphate reductase 1, alpha subunit [KO:K00525] [EC:1.17.4.1]
JW2229  nrdB; ribonucleoside diphosphate reductase 1, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
JW2288  yfbR; deoxyribonucleoside 5'-monophosphatase [KO:K08722] [EC:3.1.3.89]
JW2309  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
JW2358  yfdR; conserved hypothetical protein [KO:K06952] [EC:3.1.3.89]
JW2398  xapA; purine nucleoside phosphorylase II [KO:K03783] [EC:2.4.2.1]
JW2461  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase [KO:K01923] [EC:6.3.2.6]
JW2484  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
JW2485  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
JW2487  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
JW2491  guaA; GMP synthetase [KO:K01951] [EC:6.3.5.2]
JW2502  ndk; multifunctional nucleoside diphosphate kinase, apyrimidinic endonuclease, and 3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
JW2541  purL; phosphoribosylformyl-glycineamide synthetase [KO:K01952] [EC:6.3.5.3]
JW2575  yfiH; conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
JW2650  nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit [KO:K00525] [EC:1.17.4.1]
JW2651  nrdF; ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
JW2714  surE; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
JW2720  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
JW2721  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
JW2722  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
JW2752  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
JW2755  relA; (p)ppGpp synthetase I/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
JW2766  ygdH; conserved hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
JW2835  xdhB; xanthine dehydrogenase, FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
JW2836  xdhC; xanthine dehydrogenase, Fe-S binding subunit [KO:K13480]
JW2842  yqeA; predicted amino acid kinase [KO:K00926] [EC:2.7.2.2]
JW2921  yggV; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
JW3000  cpdA; cyclic 3',5'-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
JW3002  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
JW3343  yhfW; predicted mutase [KO:K01839] [EC:5.4.2.7]
JW3360  nudE; ADP-ribose diphosphatase [KO:K08312] [EC:3.6.1.-]
JW3623  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
JW3625  spoT; bifunctional (p)ppGpp synthetase II and guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
JW3640  ade; cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
JW3778  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
JW3969  purD; phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
JW3970  purH; fused IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
JW4135  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
JW4171  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
JW4197  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
JW4346  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
JW4347  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
JW5009  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
JW5401  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
JW5462  xdhA; xanthine dehydrogenase, molybdenum binding subunit [KO:K00087] [EC:1.17.1.4]
JW5466  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
JW5603  gpp; guanosine pentaphosphatase/exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
JW5801  yjjX; thiamin metabolism associated protein [KO:K01529]
JW5865  yrfG; predicted hydrolase [KO:K20881] [EC:3.1.3.-]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecj00030  Pentose phosphate pathway
ecj00220  Arginine biosynthesis
ecj00250  Alanine, aspartate and glutamate metabolism
ecj00260  Glycine, serine and threonine metabolism
ecj00340  Histidine metabolism
ecj00630  Glyoxylate and dicarboxylate metabolism
ecj00730  Thiamine metabolism
ecj00740  Riboflavin metabolism
ecj00790  Folate biosynthesis
KO pathway
ko00230   

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