KEGG   PATHWAY: fca00564
Entry
fca00564                    Pathway                                
Name
Glycerophospholipid metabolism - Felis catus (domestic cat)
Class
Metabolism; Lipid metabolism
Pathway map
fca00564  Glycerophospholipid metabolism
fca00564

Module
fca_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:fca00564]
fca_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:fca00564]
fca_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:fca00564]
Other DBs
GO: 0006650
Organism
Felis catus (domestic cat) [GN:fca]
Gene
101080683  LYPLA1; acyl-protein thioesterase 1 isoform X2 [KO:K06128] [EC:3.1.1.5]
101081105  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101081213  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
101081436  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
101081971  CRLS1; cardiolipin synthase (CMP-forming) isoform X2 [KO:K08744] [EC:2.7.8.41]
101082033  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101082107  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
101082138  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
101082147  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
101082396  GPAT4; glycerol-3-phosphate acyltransferase 4 isoform X2 [KO:K13506] [EC:2.3.1.15]
101082574  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
101082814  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
101082828  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101082829  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101083195  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101083225  LCAT; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
101083342  [KO:K16342] [EC:3.1.1.4]
101083437  CHKB; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101083673  GPAT3; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
101083765  SELENOI; ethanolaminephosphotransferase 1 isoform X1 [KO:K00993] [EC:2.7.8.1]
101083967  CHKA; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101083969  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101084052  PLD1; phospholipase D1 isoform X2 [KO:K01115] [EC:3.1.4.4]
101084092  TAFAZZIN; tafazzin isoform X2 [KO:K13511] [EC:2.3.1.-]
101085161  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101085320  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
101085397  DGKD; diacylglycerol kinase delta isoform X4 [KO:K00901] [EC:2.7.1.107]
101085521  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [KO:K13514] [EC:2.3.1.-]
101085603  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
101085623  LPIN1; phosphatidate phosphatase LPIN1 isoform X4 [KO:K15728] [EC:3.1.3.4]
101086099  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X2 [KO:K14676] [EC:3.1.1.5]
101086577  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
101087151  PLPP5; phospholipid phosphatase 5 isoform X2 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101087178  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
101087348  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
101087400  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
101087806  DGKH; diacylglycerol kinase eta isoform X6 [KO:K00901] [EC:2.7.1.107]
101087986  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
101088035  PEMT; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
101088071  CDS2; phosphatidate cytidylyltransferase 2 isoform X3 [KO:K00981] [EC:2.7.7.41]
101088418  PLD4; 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
101088419  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
101088547  PLPP1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
101088574  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
101088826  DGKI; diacylglycerol kinase iota isoform X4 [KO:K00901] [EC:2.7.1.107]
101088986  PLPP2; phospholipid phosphatase 2 isoform X2 [KO:K01080] [EC:3.1.3.4]
101089599  PLB1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101089953  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
101090007  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101090013  MBOAT1; lysophospholipid acyltransferase 1 isoform X5 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101090183  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
101090468  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
101090719  PLAAT3; phospholipase A and acyltransferase 3 isoform X3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101090897  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
101090943  LPCAT4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
101091087  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
101091384  [KO:K01047] [EC:3.1.1.4]
101091639  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101091796  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
101091884  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101092035  PLA2G2C; LOW QUALITY PROTEIN: putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101092214  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101092526  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
101092547  SAMD8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:3.1.4.62]
101092977  PLA2G15; phospholipase A2 group XV isoform X3 [KO:K06129] [EC:3.1.1.5]
101093135  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
101093451  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
101093696  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
101093729  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
101094629  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
101094635  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X3 [KO:K13509] [EC:2.3.1.51]
101094704  PLPP4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101095078  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X3 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101095209  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
101095350  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101095498  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X3 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101095522  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101095719  PCYT1B; choline-phosphate cytidylyltransferase B isoform X7 [KO:K00968] [EC:2.7.7.15]
101095760  PLPP3; phospholipid phosphatase 3 isoform X3 [KO:K01080] [EC:3.1.3.4]
101096064  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2 [KO:K13509] [EC:2.3.1.51]
101096148  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
101096222  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
101096267  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101097119  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
101097705  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
101099061  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
101099093  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101099320  PCYT1A; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
101099405  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X4 [KO:K01613] [EC:4.1.1.65]
101099986  CHPT1; cholinephosphotransferase 1 isoform X2 [KO:K00994] [EC:2.7.8.2]
101100427  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X2 [KO:K00967] [EC:2.7.7.14]
101100829  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
101101267  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
101101522  MBOAT7; lysophospholipid acyltransferase 7 isoform X2 [KO:K13516] [EC:2.3.1.-]
101101581  [KO:K13618] [EC:3.1.1.111]
493674  ACHE; acetylcholinesterase precursor [KO:K01049] [EC:3.1.1.7]
751512  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
fca00010  Glycolysis / Gluconeogenesis
fca00260  Glycine, serine and threonine metabolism
fca00561  Glycerolipid metabolism
fca00562  Inositol phosphate metabolism
fca00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
fca00565  Ether lipid metabolism
fca00620  Pyruvate metabolism
KO pathway
ko00564   

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