KEGG   PATHWAY: fca00260
Entry
fca00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Felis catus (domestic cat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
fca00260  Glycine, serine and threonine metabolism
fca00260

Module
fca_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:fca00260]
fca_M00047  Creatine pathway [PATH:fca00260]
fca_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:fca00260]
fca_M00555  Betaine biosynthesis, choline => betaine [PATH:fca00260]
fca_M00621  Glycine cleavage system [PATH:fca00260]
fca_M00974  Betaine metabolism, animals, betaine => glycine [PATH:fca00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100302391  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X2 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
101080592  AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
101080876  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
101081589  [KO:K01620] [EC:4.1.2.48]
101081790  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
101082200  PSPH; phosphoserine phosphatase isoform X4 [KO:K01079] [EC:3.1.3.3]
101082702  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
101083006  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
101083282  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
101083586  [KO:K15789] [EC:1.1.1.103]
101084333  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
101084781  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
101085179  BHMT; betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
101086266  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
101086623  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101086928  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101087429  DAO; D-amino-acid oxidase isoform X3 [KO:K00273] [EC:1.4.3.3]
101088505  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101089168  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X2 [KO:K00315] [EC:1.5.8.4]
101089175  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
101089899  SDSL; serine dehydratase-like isoform X2 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101091290  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
101091848  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
101092086  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
101093038  CBS; cystathionine beta-synthase isoform X4 [KO:K01697] [EC:4.2.1.22]
101094004  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
101094711  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101094834  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
101095525  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
101095553  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
101095644  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
101096703  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
101097947  AGXT2; LOW QUALITY PROTEIN: alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101098880  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
101098904  SRR; serine racemase isoform X2 [KO:K12235] [EC:5.1.1.18]
101099081  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
101100163  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
102899556  [KO:K02437]
123378914  AOC3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
414734  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
727692  AGXT; serine--pyruvate aminotransferase, mitochondrial precursor [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
fca00010  Glycolysis / Gluconeogenesis
fca00020  Citrate cycle (TCA cycle)
fca00230  Purine metabolism
fca00250  Alanine, aspartate and glutamate metabolism
fca00270  Cysteine and methionine metabolism
fca00290  Valine, leucine and isoleucine biosynthesis
fca00330  Arginine and proline metabolism
fca00470  D-Amino acid metabolism
fca00564  Glycerophospholipid metabolism
fca00600  Sphingolipid metabolism
fca00620  Pyruvate metabolism
fca00630  Glyoxylate and dicarboxylate metabolism
fca00640  Propanoate metabolism
fca00860  Porphyrin metabolism
fca00920  Sulfur metabolism
KO pathway
ko00260   

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