KEGG   PATHWAY: fcy00260
Entry
fcy00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Fragilariopsis cylindrus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
fcy00260  Glycine, serine and threonine metabolism
fcy00260

Module
fcy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:fcy00260]
fcy_M00621  Glycine cleavage system [PATH:fcy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Fragilariopsis cylindrus [GN:fcy]
Gene
FRACYDRAFT_148447  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FRACYDRAFT_273718  bifunctional aspartokinase/homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
FRACYDRAFT_211032  aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
FRACYDRAFT_207688  Homoserine_dh-domain-containing protein [KO:K00003] [EC:1.1.1.3]
FRACYDRAFT_209539  homoserine kinase [KO:K00872] [EC:2.7.1.39]
FRACYDRAFT_207067  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
FRACYDRAFT_236986  threonine aldolase [KO:K01620] [EC:4.1.2.48]
FRACYDRAFT_291505  cSHMT; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FRACYDRAFT_252263  mSHMT_1; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FRACYDRAFT_277738  cSMHT; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FRACYDRAFT_239548  mSHMT_1; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FRACYDRAFT_169636  NAD(P)-binding protein [KO:K00049] [EC:1.1.1.79 1.1.1.81]
FRACYDRAFT_291583  GK1; glycerate kinase [KO:K11529] [EC:2.7.1.165]
FRACYDRAFT_211179  PGAM1; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
FRACYDRAFT_247569  hypothetical protein [KO:K01834] [EC:5.4.2.11]
FRACYDRAFT_238967  hypothetical protein [KO:K01834] [EC:5.4.2.11]
FRACYDRAFT_250143  PGAM10; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
FRACYDRAFT_239120  PGAM4; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
FRACYDRAFT_252624  hypothetical protein [KO:K01834] [EC:5.4.2.11]
FRACYDRAFT_181253  D-isomer-specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FRACYDRAFT_224007  D-isomer-specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FRACYDRAFT_194145  phosphoserine aminotransferas-like protein 1 [KO:K00831] [EC:2.6.1.52]
FRACYDRAFT_195514  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
FRACYDRAFT_261984  phosphoserine phosphatase serb [KO:K01079] [EC:3.1.3.3]
FRACYDRAFT_276117  GDCP; glycine cleavage system P-protein [KO:K00281] [EC:1.4.4.2]
FRACYDRAFT_224733  GDCT; mitochondrial glycine decarboxylase T-protein [KO:K00605] [EC:2.1.2.10]
FRACYDRAFT_230231  GDCT; glycine decarboxylase T-protein [KO:K00605] [EC:2.1.2.10]
FRACYDRAFT_271375  DLDH; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FRACYDRAFT_186500  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
FRACYDRAFT_222240  GDCH; glycine decarboxylase H-protein [KO:K02437]
FRACYDRAFT_275698  GDCH; GCV_H-domain-containing protein [KO:K02437]
FRACYDRAFT_206086  nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
FRACYDRAFT_188279  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K01754] [EC:4.3.1.19]
FRACYDRAFT_185545  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
FRACYDRAFT_206137  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K12235] [EC:5.1.1.18]
FRACYDRAFT_169676  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
FRACYDRAFT_251137  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
fcy00010  Glycolysis / Gluconeogenesis
fcy00020  Citrate cycle (TCA cycle)
fcy00230  Purine metabolism
fcy00250  Alanine, aspartate and glutamate metabolism
fcy00270  Cysteine and methionine metabolism
fcy00290  Valine, leucine and isoleucine biosynthesis
fcy00300  Lysine biosynthesis
fcy00330  Arginine and proline metabolism
fcy00460  Cyanoamino acid metabolism
fcy00470  D-Amino acid metabolism
fcy00564  Glycerophospholipid metabolism
fcy00600  Sphingolipid metabolism
fcy00620  Pyruvate metabolism
fcy00630  Glyoxylate and dicarboxylate metabolism
fcy00640  Propanoate metabolism
fcy00860  Porphyrin metabolism
fcy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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